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Gabapentin treatment for alcohol dependence: a randomized clinical trial.

Mason BJ, Quello S, Goodell V, Shadan F, Kyle M, Begovic A. Mason BJ, et al. JAMA Intern Med. 2014 Jan;174(1):70-7. doi: 10.1001/jamainternmed.2013.11950. JAMA Intern Med. 2014. PMID: 24190578 Free PMC article. Clinical Trial.

IMPORTANCE: Approved medications for alcohol dependence are prescribed for less than 9% of US alcoholics. ...Increased implementation of pharmacological treatment of alcohol dependence in primary care may be a major benefit of gabapentin as a treatment option …

IMPORTANCE: Approved medications for alcohol dependence are prescribed for less than 9% of US alcoholics. ...Increased impleme …

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Individualized treatment for alcohol withdrawal. A randomized double-blind controlled trial.

Saitz R, Mayo-Smith MF, Roberts MS, Redmond HA, Bernard DR, Calkins DR. Saitz R, et al. JAMA. 1994 Aug 17;272(7):519-23. JAMA. 1994. PMID: 8046805 Clinical Trial.

OBJECTIVE: To assess the effect of an individualized treatment regimen on the intensity and duration of medication treatment for alcohol withdrawal. DESIGN: A randomized double-blind, controlled trial. ...PATIENTS: One hundred one patients admitted for the treatment of …

OBJECTIVE: To assess the effect of an individualized treatment regimen on the intensity and duration of medication treatment for alcohol …

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Double-Blind Randomized Clinical Trial of Prazosin for Alcohol Use Disorder.

Simpson TL, Saxon AJ, Stappenbeck C, Malte CA, Lyons R, Tell D, Millard SP, Raskind M. Simpson TL, et al. Am J Psychiatry. 2018 Dec 1;175(12):1216-1224. doi: 10.1176/appi.ajp.2018.17080913. Epub 2018 Aug 29. Am J Psychiatry. 2018. PMID: 30153753 Free PMC article. Clinical Trial.

OBJECTIVE: Current medications for alcohol use disorder do not target brain noradrenergic pathways. Theoretical and preclinical evidence suggests that noradrenergic circuits may be involved in alcohol reinforcement and relapse. After a positive pilot study, the auth …

OBJECTIVE: Current medications for alcohol use disorder do not target brain noradrenergic pathways. Theoretical and preclinical evide …

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Exploring the Role of Alcohol Metabolizing Genotypes in a 12-Week Clinical Trial of Naltrexone for Alcohol Use Disorder.

Castaldelli-Maia JM, Malbergier A, de Oliveira ABP, Amaral RA, Negrão AB, Gonçalves PD, Ventriglio A, de Berardis D, de Antonio J, Firigato I, Gattás GJF, de Toledo Gonçalves F. Castaldelli-Maia JM, et al. Biomolecules. 2021 Oct 10;11(10):1495. doi: 10.3390/biom11101495. Biomolecules. 2021. PMID: 34680127 Free PMC article. Clinical Trial.

The outcome of alcohol use has been monitored employing the timeline follow-back during the treatment. ...Further studies should be performed to investigate the relationship between alcohol metabolizing genotypes, the family history of alcohol use disorders a …

The outcome of alcohol use has been monitored employing the timeline follow-back during the treatment. ...Further studies should be p …

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Changing Alcohol Cravings Using Social Media Comments.

Noel JK, Lakhan HA. Noel JK, et al. Subst Use Misuse. 2021;56(3):377-387. doi: 10.1080/10826084.2020.1868518. Epub 2021 Jan 10. Subst Use Misuse. 2021. PMID: 33427009 Clinical Trial.

Alcohol cravings, measured using the Desires for Alcohol Questionnaire (DAQ), were assessed before and after ad exposure. ...Conclusions: The findings suggest that user-generated comments can influence the desire to drink and smoking urges, beyond the effects of ads …

Alcohol cravings, measured using the Desires for Alcohol Questionnaire (DAQ), were assessed before and after ad exposure. ...C …

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Pilot investigation: randomized-controlled analog trial for alcohol and tobacco smoking co-addiction using contingency management.

Orr MF, Lederhos Smith C, Finlay M, Martin SC, Brooks O, Oluwoye OA, Leickly E, McDonell M, Burduli E, Barbosa-Leiker C, Layton M, Roll JM, McPherson SM. Orr MF, et al. Behav Pharmacol. 2018 Aug;29(5):462-468. doi: 10.1097/FBP.0000000000000379. Behav Pharmacol. 2018. PMID: 29561290 Free PMC article. Clinical Trial.

We used a 2 [CM vs. noncontingent control (NC) for alcohol]2 (CM vs. NC for smoking tobacco) factorial design, with alcohol intake (through urinary ethyl glucuronide) and tobacco smoking (through urinary cotinine) as the primary outcomes. ...Similarly, compared with …

We used a 2 [CM vs. noncontingent control (NC) for alcohol]2 (CM vs. NC for smoking tobacco) factorial design, with alcohol in …

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Filling the gap between lab and clinical impact: An open randomized diagnostic trial comparing urinary ethylglucuronide and ethanol in alcohol dependent outpatients.

Barrio P, Teixidor L, Ortega L, Lligoña A, Rico N, Bedini JL, Vieta E, Gual A. Barrio P, et al. Drug Alcohol Depend. 2018 Feb 1;183:225-230. doi: 10.1016/j.drugalcdep.2017.11.015. Epub 2017 Dec 27. Drug Alcohol Depend. 2018. PMID: 29291550 Clinical Trial.

The aim of this study was to assess, in a randomized design, the implications of EtG screening on alcohol outcomes, compared to screening with a low sensitivity biomarker such as ethanol. METHODS: Alcohol dependent outpatients were randomized to either 24 wee …

The aim of this study was to assess, in a randomized design, the implications of EtG screening on alcohol outcomes, compared to scree …

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Acute alcohol effects on impulsive choice in adolescents.

Bernhardt N, Obst E, Nebe S, Pooseh S, Wurst FM, Weinmann W, Smolka MN, Zimmermann US. Bernhardt N, et al. J Psychopharmacol. 2019 Mar;33(3):316-325. doi: 10.1177/0269881118822063. Epub 2019 Jan 24. J Psychopharmacol. 2019. PMID: 30676200 Clinical Trial.

Further, higher risk aversion for probabilistic gains and higher loss aversion during alcohol condition were related to higher levels of real-life alcohol consumption and a family history of alcohol problems, respectively. ...It rather appears that alcohol …

Further, higher risk aversion for probabilistic gains and higher loss aversion during alcohol condition were related to higher levels …

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Naltrexone and alcohol effects on craving for cigarettes in heavy drinking smokers.

Green R, Bujarski S, Lim AC, Venegas A, Ray LA. Green R, et al. Exp Clin Psychopharmacol. 2019 Jun;27(3):257-264. doi: 10.1037/pha0000252. Epub 2019 Jan 10. Exp Clin Psychopharmacol. 2019. PMID: 30628813 Free PMC article. Clinical Trial.

Self-reported subjective craving for cigarettes and for alcohol was recorded during each experimental session. Craving for cigarettes and alcohol increased significantly throughout the intravenous alcohol administration. ...Naltrexone significantly reduced cr …

Self-reported subjective craving for cigarettes and for alcohol was recorded during each experimental session. Craving for cigarettes …

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A randomized clinical trial of a targeted intervention to moderate alcohol use and alcohol-related problems in at-risk adolescents.

Thush C, Wiers RW, Theunissen N, Van den Bosch J, Opdenacker J, van Empelen P, Moerbeek M, Feron FJ. Thush C, et al. Pharmacol Biochem Behav. 2007 Feb;86(2):368-76. doi: 10.1016/j.pbb.2006.07.023. Epub 2006 Aug 22. Pharmacol Biochem Behav. 2007. PMID: 16928395 Clinical Trial.

Additionally, this intervention contained the new element of discussing biological, cognitive and social risk factors for developing alcohol problems. We investigated whether this seven session program was successful in changing cognitive determinants of drinking behavior …

Additionally, this intervention contained the new element of discussing biological, cognitive and social risk factors for developing alco …

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