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Page 1
Effect of Alendronic Acid on Fracture Healing: A Multicenter Randomized Placebo-Controlled Trial.
Duckworth AD, McQueen MM, Tuck CE, Tobias JH, Wilkinson JM, Biant LC, Pulford EC, Aldridge S, Edwards C, Roberts CP, Ramachandran M, McAndrew AR, Cheng KC, Johnston P, Shah NH, Mathew P, Harvie J, Hanusch BC, Harkess R, Rodriguez A, Murray GD, Ralston SH. Duckworth AD, et al. J Bone Miner Res. 2019 Jun;34(6):1025-1032. doi: 10.1002/jbmr.3679. Epub 2019 Mar 7. J Bone Miner Res. 2019. PMID: 30845365 Free article. Clinical Trial.
We enrolled 421 bisphosphonate-naive patients aged 50 years with a radiographically confirmed fracture of the distal radius and randomized them in a 1:1 ratio to receive alendronic acid 70 mg once weekly (n = 215) or placebo (n = 206) within 14 days of the fracture …
We enrolled 421 bisphosphonate-naive patients aged 50 years with a radiographically confirmed fracture of the distal radius and randomized …
Effect of Denosumab or Alendronate on Vascular Calcification: Secondary Analysis of SALTIRE2 Randomized Controlled Trial.
Geers J, Bing R, Pawade TA, Doris MK, Daghem M, Fletcher AJ, White AC, Forsyth L, Evans E, Kwieciński J, Williams MC, van Beek EJR, Kwak S, Peeters FECM, Tzolos E, Slomka PJ, Lucatelli C, Ralston SH, Prendergast B, Newby DE, Dweck MR. Geers J, et al. J Am Heart Assoc. 2024 Sep 17;13(18):e032571. doi: 10.1161/JAHA.123.032571. Epub 2024 Sep 9. J Am Heart Assoc. 2024. PMID: 39248270 Free PMC article. Clinical Trial.
One hundred fifty patients with aortic stenosis (72 8 years; 21% female) were randomized to denosumab (n=49), alendronic acid (n=51), and placebo (injection n=25, capsule n=25). There were no differences in change in coronary calcium scores between placebo (16 [-64 …
One hundred fifty patients with aortic stenosis (72 8 years; 21% female) were randomized to denosumab (n=49), alendronic acid …
Alendronic acid produces greater effects than risedronic acid on bone density and turnover in postmenopausal women with osteoporosis : results of FACTS -international.
Reid DM, Hosking D, Kendler D, Brandi ML, Wark JD, Weryha G, Marques-Neto JF, Gaines KA, Verbruggen N, Melton ME. Reid DM, et al. Clin Drug Investig. 2006;26(2):63-74. doi: 10.2165/00044011-200626020-00002. Clin Drug Investig. 2006. PMID: 17163237 Clinical Trial.
Patients were randomised to treatment with either active alendronic acid 70 mg weekly (Fosamax) and placebo identical to risedronic acid weekly or active risedronic acid 35 mg weekly (Actonel) and placebo identical to alendronic acid weekly for 12 mont …
Patients were randomised to treatment with either active alendronic acid 70 mg weekly (Fosamax) and placebo identical to rised …
Esophageal transit and in vivo disintegration of branded risedronate sodium tablets and two generic formulations of alendronic acid tablets: a single-center, single-blind, six-period crossover study in healthy female subjects.
Perkins AC, Blackshaw PE, Hay PD, Lawes SC, Atherton CT, Dansereau RJ, Wagner LK, Schnell DJ, Spiller RC. Perkins AC, et al. Clin Ther. 2008 May;30(5):834-44. doi: 10.1016/j.clinthera.2008.04.018. Clin Ther. 2008. PMID: 18555931 Clinical Trial.
Each subject received a single oral dose of a branded risedronate sodium 35-mg tablet and 2 generic formulations of alendronic acid 70-mg tablets (Novopharm Limited, Toronto, Canada, and Teva UK Limited, Morley, United Kingdom) in both the erect and semisupine (45 d …
Each subject received a single oral dose of a branded risedronate sodium 35-mg tablet and 2 generic formulations of alendronic aci …
Effect of Denosumab or Alendronic Acid on the Progression of Aortic Stenosis: A Double-Blind Randomized Controlled Trial.
Pawade TA, Doris MK, Bing R, White AC, Forsyth L, Evans E, Graham C, Williams MC, van Beek EJR, Fletcher A, Adamson PD, Andrews JPM, Cartlidge TRG, Jenkins WSA, Syed M, Fujisawa T, Lucatelli C, Fraser W, Ralston SH, Boon N, Prendergast B, Newby DE, Dweck MR. Pawade TA, et al. Circulation. 2021 Jun 22;143(25):2418-2427. doi: 10.1161/CIRCULATIONAHA.121.053708. Epub 2021 Apr 29. Circulation. 2021. PMID: 33913339 Free PMC article. Clinical Trial.
We aimed to establish whether inhibition of these pathways with denosumab or alendronic acid could reduce disease progression in aortic stenosis. METHODS: In a single-center, parallel group, double-blind randomized controlled trial, patients >50 years of age with …
We aimed to establish whether inhibition of these pathways with denosumab or alendronic acid could reduce disease progression …
Effects of bisphosphonates on fracture incidence and bone metabolism in rheumatoid arthritis patients in general practice taking long-term corticosteroid therapy: a retrospective study.
Katayama K, Matsuno T. Katayama K, et al. Clin Drug Investig. 2008;28(3):149-58. doi: 10.2165/00044011-200828030-00002. Clin Drug Investig. 2008. PMID: 18266400 Clinical Trial.
METHODS: The subjects were 138 general practice patients aged 50-79 years with RA (alendronic acid group 80; risedronic acid group 58) who received oral prednisolone at a dose of 2-15 mg/day for at least 1 year combined with bisphosphonate therapy (alendronic …
METHODS: The subjects were 138 general practice patients aged 50-79 years with RA (alendronic acid group 80; risedronic acid g …
In vitro disintegration and dissolution and in vivo bioequivalence of two alendronate once-weekly formulations.
Almeida S, Almeida A, Filipe A, Penedo C, Rocha A, Lainesse A, Vallée F. Almeida S, et al. Arzneimittelforschung. 2006;56(2):84-9. doi: 10.1055/s-0031-1296706. Arzneimittelforschung. 2006. PMID: 16572922 Clinical Trial.
Urine samples were collected up to +36 h post dosing and the concentrations of alendronic acid were assessed using a high-performance liquid chromatographic method with pre-derivatization and fluorescence detection (HPLC/FL) method. ...
Urine samples were collected up to +36 h post dosing and the concentrations of alendronic acid were assessed using a high-perf …
Two-way crossover bioequivalence study of alendronate sodium tablets in healthy, non-smoking male volunteers under fasted conditions.
Thudi NR, Gagnon S, Hussain S, Abolfathi Z, Singla A, Pai R, Kumar S, Monif T. Thudi NR, et al. Arzneimittelforschung. 2009;59(10):521-5. doi: 10.1055/s-0031-1296436. Arzneimittelforschung. 2009. PMID: 19998580 Clinical Trial.
Urine samples were collected up to 36 h post-dose, and the concentrations of alendronic acid were determined using a high performance liquid chromatographic method with pre-derivatization and fluorescence detection (HPLC/FL) method. ...The 90% confidence intervals f …
Urine samples were collected up to 36 h post-dose, and the concentrations of alendronic acid were determined using a high perf …
ALX 111: ALX1-11, parathyroid hormone (1-84) - NPS Allelix, PREOS, PTH, recombinant human parathyroid hormone, rhPTH (1-84).
Adis International Ltd. Adis International Ltd. Drugs R D. 2003;4(4):231-5. doi: 10.2165/00126839-200304040-00003. Drugs R D. 2003. PMID: 12848587 Clinical Trial.
The PaTH study, initiated in May 2000 and scheduled to conclude in September 2003, involved 238 patients with postmenopausal osteoporosis. It is thought that alendronic acid and ALX 111, when administered in combination, may act in an additive manner to treat osteop …
The PaTH study, initiated in May 2000 and scheduled to conclude in September 2003, involved 238 patients with postmenopausal osteoporosis. I …
Bioequivalence of generic alendronate sodium tablets (70 mg) to Fosamax® tablets (70 mg) in fasting, healthy volunteers: a randomized, open-label, three-way, reference-replicated crossover study.
Zhang Y, Chen X, Tang Y, Lu Y, Guo L, Zhong D. Zhang Y, et al. Drug Des Devel Ther. 2017 Jul 11;11:2109-2119. doi: 10.2147/DDDT.S138286. eCollection 2017. Drug Des Devel Ther. 2017. PMID: 28744102 Free PMC article. Clinical Trial.
RESULTS: The average maximum concentrations (C(max)) of alendronic acid were 64.78 43.76, 56.62 31.95, and 60.15 37.12 ng/mL after the single dose of the generic product and the first and second doses of the reference product, respectively. ...
RESULTS: The average maximum concentrations (C(max)) of alendronic acid were 64.78 43.76, 56.62 31.95, and 60.15 37.12 ng/mL a …