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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1980 3
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1982 5
1983 14
1984 12
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1987 22
1988 29
1989 21
1990 39
1991 39
1992 31
1993 31
1994 32
1995 25
1996 17
1997 19
1998 28
1999 21
2000 14
2001 8
2002 7
2003 17
2004 11
2005 21
2006 10
2007 15
2008 9
2009 12
2010 4
2011 10
2012 9
2013 3
2014 12
2015 9
2016 5
2017 6
2018 6
2019 7
2020 5
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2022 4
2023 5
2024 5
2025 3
2026 0

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642 results

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Page 1
Alprazolam: pharmacokinetics, clinical efficacy, and mechanism of action.
Fawcett JA, Kravitz HM. Fawcett JA, et al. Pharmacotherapy. 1982 Sep-Oct;2(5):243-54. doi: 10.1002/j.1875-9114.1982.tb03191.x. Pharmacotherapy. 1982. PMID: 6133268 Review.
Alprazolam, a triazolobenzodiazepine, is the first of this new class of benzodiazepine drugs to be marketed in the United States and Canada. ...Alprazolam has been used in elderly patients with beneficial results and a low frequency of adverse reactions. ...
Alprazolam, a triazolobenzodiazepine, is the first of this new class of benzodiazepine drugs to be marketed in the United States and …
Age-related digoxin-alprazolam interaction.
Guven H, Tuncok Y, Guneri S, Cavdar C, Fowler J. Guven H, et al. Clin Pharmacol Ther. 1993 Jul;54(1):42-4. doi: 10.1038/clpt.1993.107. Clin Pharmacol Ther. 1993. PMID: 8330464 Clinical Trial.
A case report of dramatic increases in serum digoxin levels after alprazolam administration prompted our investigation. Twelve inpatients receiving long-term digoxin (0.25 mg daily) randomly received oral administration of either 1.0 or 0.5 mg alprazolam per day for …
A case report of dramatic increases in serum digoxin levels after alprazolam administration prompted our investigation. Twelve inpati …
Cognitive effects, pharmacokinetics, and safety of zuranolone administered alone or with alprazolam or ethanol in healthy adults in a phase 1 trial.
Dunbar J, Walling DP, Hassman HA, Jain R, Czysz A, Nandy I, Ona V, Moseley MK, Levin S, Maruff P. Dunbar J, et al. J Psychopharmacol. 2024 Dec;38(12):1122-1136. doi: 10.1177/02698811241282777. Epub 2024 Oct 11. J Psychopharmacol. 2024. PMID: 39394685 Free PMC article. Clinical Trial.
Compared to placebo, zuranolone produced small-to-moderate cognitive decline (Cohen's |d| = 0.126-0.76); effects were larger with alprazolam (Cohen's |d| = 0.523-0.93) and ethanol (Cohen's |d| = 0.345-0.88). Zuranolone coadministration with alprazolam (Cohen's |d| = …
Compared to placebo, zuranolone produced small-to-moderate cognitive decline (Cohen's |d| = 0.126-0.76); effects were larger with alprazo …
A randomized, multicenter trial assessing the effects of rapastinel compared to ketamine, alprazolam, and placebo on simulated driving performance.
Su S, Kay G, Hochadel T, Rojo J, Christopher Stein J, Boinpally R, Periclou A. Su S, et al. Clin Transl Sci. 2022 Jan;15(1):255-266. doi: 10.1111/cts.13145. Epub 2021 Nov 7. Clin Transl Sci. 2022. PMID: 34423904 Free PMC article. Clinical Trial.

Sensitivity of the assays was confirmed with alprazolam (all placebo comparisons p < 0.02). Rapastinel 900 and 1800 mg did not significantly affect simulated driving performance compared to placebo (both p > 0.5). Both rapastinel doses resulted in significantly less

…

Sensitivity of the assays was confirmed with alprazolam (all placebo comparisons p < 0.02). Rapastinel 900 and 1800 mg did not sig

…
Alprazolam as an antidepressant.
Warner MD, Peabody CA, Whiteford HA, Hollister LE. Warner MD, et al. J Clin Psychiatry. 1988 Apr;49(4):148-50. J Clin Psychiatry. 1988. PMID: 3281931 Review.
Alprazolam appears to be an effective antidepressant in the treatment of outpatients who have a diagnosis of major depressive disorder. ...No satisfactory explanation exists for the mechanism of alprazolam's proposed antidepressant action....
Alprazolam appears to be an effective antidepressant in the treatment of outpatients who have a diagnosis of major depressive disorde …
A double-blind trial of oral progesterone, alprazolam, and placebo in treatment of severe premenstrual syndrome.
Freeman EW, Rickels K, Sondheimer SJ, Polansky M. Freeman EW, et al. JAMA. 1995 Jul 5;274(1):51-7. JAMA. 1995. PMID: 7791258 Clinical Trial.
OBJECTIVE: To determine the effectiveness of oral micronized progesterone, alprazolam, and placebo in premenstrual syndrome (PMS) treatment and the effect of clinical contact on treatment responses. ...Thirty-seven percent of the alprazolam group experienced a 50% r …
OBJECTIVE: To determine the effectiveness of oral micronized progesterone, alprazolam, and placebo in premenstrual syndrome (PMS) tre …
A controlled clinical trial of alprazolam for the treatment of anxiety.
Rickels K, Csanalosi I, Greisman P, Cohen D, Werblowsky J, Ross HA, Harris H. Rickels K, et al. Am J Psychiatry. 1983 Jan;140(1):82-5. doi: 10.1176/ajp.140.1.82. Am J Psychiatry. 1983. PMID: 6128927 Clinical Trial.
Alprazolam and diazepam produced similar clinical improvement, which was significantly larger than improvement produced by placebo and was clearly evident after only 1 week of treatment. The incidence of sedation was lower with alprazolam than with diazepam....
Alprazolam and diazepam produced similar clinical improvement, which was significantly larger than improvement produced by placebo an …
Alprazolam in panic disorder and agoraphobia: results from a multicenter trial. III. Discontinuation effects.
Pecknold JC, Swinson RP, Kuch K, Lewis CP. Pecknold JC, et al. Arch Gen Psychiatry. 1988 May;45(5):429-36. doi: 10.1001/archpsyc.1988.01800290043006. Arch Gen Psychiatry. 1988. PMID: 3282479 Clinical Trial.
Sixty of the 63 alprazolam-treated patients and 49 of the 63 placebo-treated patients entered the taper and discontinuation study. ...No serious or life-threatening withdrawal symptoms were reported, but distinct, transient, mild to moderate withdrawal syndrome occurred in …
Sixty of the 63 alprazolam-treated patients and 49 of the 63 placebo-treated patients entered the taper and discontinuation study. .. …
Double-blind clinical study comparing alprazolam and doxepin in primary unipolar depression.
Ansseau M, Ansoms C, Beckers G, Bogaerts M, Botte L, De Buck R, Diricq S, Dumortier A, Jansegers E, Owieczka J, et al. Ansseau M, et al. J Affect Disord. 1984 Dec;7(3-4):287-96. doi: 10.1016/0165-0327(84)90050-8. J Affect Disord. 1984. PMID: 6151958 Free article. Clinical Trial.
Patients were treated with a flexible dose of 1.0-4.5 mg of alprazolam and 50-225 mg of doxepin per day. The mean final doses were 2.7 mg for alprazolam and 137.5 mg for doxepin. The results indicate that alprazolam and doxepin were equally efficacious. The i …
Patients were treated with a flexible dose of 1.0-4.5 mg of alprazolam and 50-225 mg of doxepin per day. The mean final doses were 2. …
Panic disorder: long-term pharmacotherapy and discontinuation.
Rickels K, Schweizer E. Rickels K, et al. J Clin Psychopharmacol. 1998 Dec;18(6 Suppl 2):12S-18S. doi: 10.1097/00004714-199812001-00004. J Clin Psychopharmacol. 1998. PMID: 9872708 Review.
One hundred six PD patients were enrolled in a double-blind, 8-month, placebo-controlled trial of alprazolam and imipramine. In the 8-week short-term phase, daily dosages were titrated up to 10 mg/day of alprazolam and 250 mg/day of imipramine. ...In the 6-month mai …
One hundred six PD patients were enrolled in a double-blind, 8-month, placebo-controlled trial of alprazolam and imipramine. In the 8 …
642 results