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Structural basis of antagonist selectivity in endothelin receptors.
Hou J, Liu S, Zhang X, Tu G, Wu L, Zhang Y, Yang H, Li X, Liu J, Jiang L, Tan Q, Bai F, Liu Z, Miao C, Hua T, Luo Z. Hou J, et al. Cell Discov. 2024 Jul 30;10(1):79. doi: 10.1038/s41421-024-00705-9. Cell Discov. 2024. PMID: 39075075 Free PMC article.
Here we present cryo-electron microscopy structures of ET(A) in complex with two PAH drugs, macitentan and ambrisentan, along with zibotentan, a selective ET(A) antagonist, respectively. Notably, a specialized anti-ET(A) antibody facilitated the structural elucidation. ...
Here we present cryo-electron microscopy structures of ET(A) in complex with two PAH drugs, macitentan and ambrisentan, along with zi …
Ambrisentan improves exercise capacity and symptoms in patients with portopulmonary hypertension.
Halank M, Knudsen L, Seyfarth HJ, Ewert R, Wiedemann B, Kolditz M, Höffken G, Hoeper MM. Halank M, et al. Z Gastroenterol. 2011 Sep;49(9):1258-62. doi: 10.1055/s-0031-1273393. Epub 2011 Sep 1. Z Gastroenterol. 2011. PMID: 21887662
INTRODUCTION: Ambrisentan, a selective endothelin receptor antagonist has been approved in several countries for pulmonary arterial hypertension. No data have been published on the efficacy of ambrisentan on improvement of exercise capacity in patients with portopul …
INTRODUCTION: Ambrisentan, a selective endothelin receptor antagonist has been approved in several countries for pulmonary arterial h …