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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1968 5
1969 3
1970 1
1971 1
1972 3
1973 3
1974 2
1975 6
1976 6
1977 5
1978 11
1979 6
1980 9
1981 10
1982 9
1983 14
1984 11
1985 19
1986 20
1987 16
1988 14
1989 12
1990 15
1991 14
1992 15
1993 11
1994 9
1995 11
1996 11
1997 9
1998 10
1999 7
2000 8
2001 6
2002 11
2003 5
2004 6
2005 2
2006 4
2007 4
2008 2
2009 2
2010 4
2011 5
2012 12
2013 11
2014 8
2015 5
2016 5
2017 4
2018 5
2019 4
2020 6
2021 3
2022 3
2023 5
2024 4
2025 3
2026 2

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420 results

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Page 1
Spironolactone vs Amiloride for Resistant Hypertension: A Randomized Clinical Trial.
Lee CJ, Ihm SH, Shin DH, Jeong JO, Kim JH, Chun KH, Ryu J, Lee HY, Choi S, Lee EM, Choi JH, Kim KI, Shin J, Pyun WB, Kim DH, Park S, Williams B. Lee CJ, et al. JAMA. 2025 Jun 17;333(23):2073-2082. doi: 10.1001/jama.2025.5129. JAMA. 2025. PMID: 40366680 Free PMC article. Clinical Trial.
IMPORTANCE: Amiloride has been proposed as an alternative to spironolactone for treating resistant hypertension. However, no randomized clinical trials have compared the efficacy of spironolactone and amiloride in patients with resistant hypertension. OBJECTIVE: To …
IMPORTANCE: Amiloride has been proposed as an alternative to spironolactone for treating resistant hypertension. However, no randomiz …
Evaluating the clinical and mechanistic effects of eplerenone and amiloride monotherapy, and combination therapy with cinacalcet, in primary hyperparathyroidism: A placebo-controlled randomized trial.
Parksook WW, Heydarpour M, Brown JM, Turchin A, Mannstadt M, Vaidya A. Parksook WW, et al. Clin Endocrinol (Oxf). 2023 Apr;98(4):516-526. doi: 10.1111/cen.14840. Epub 2022 Nov 8. Clin Endocrinol (Oxf). 2023. PMID: 36316798 Free PMC article. Clinical Trial.
Both eplerenone and amiloride therapy induced significant reductions in procollagen type 1 N-terminal propeptide levels when compared to placebo. ...CONCLUSIONS: Although maximally tolerated therapy with eplerenone and amiloride induced expected changes in renin, al …
Both eplerenone and amiloride therapy induced significant reductions in procollagen type 1 N-terminal propeptide levels when compared …
Amiloride and plasma-potassium.
Surveyor I, Saunders RA. Surveyor I, et al. Lancet. 1968 Aug 31;2(7566):516-7. doi: 10.1016/s0140-6736(68)90679-x. Lancet. 1968. PMID: 4174531 Clinical Trial. No abstract available.
Amiloride Clinical Trial In Optic Neuritis (ACTION) protocol: a randomised, double blind, placebo controlled trial.
McKee JB, Elston J, Evangelou N, Gerry S, Fugger L, Kennard C, Kong Y, Palace J, Craner M. McKee JB, et al. BMJ Open. 2015 Nov 9;5(11):e009200. doi: 10.1136/bmjopen-2015-009200. BMJ Open. 2015. PMID: 26553836 Free PMC article. Clinical Trial.
The identification and evaluation of effective neuroprotective therapies within a trial paradigm are key unmet needs. Emerging evidence supports amiloride, a licenced diuretic, as a neuroprotective agent in MS through acid sensing ion channel blockade. Optic neuritis (ON) …
The identification and evaluation of effective neuroprotective therapies within a trial paradigm are key unmet needs. Emerging evidence supp …
A randomized sequential cross-over trial evaluating five purportedly ICP-lowering drugs in idiopathic intracranial hypertension.
Mitchell JL, Lyons HS, Walker JK, Yiangou A, Thaller M, Grech O, Alimajstorovic Z, Tsermoulas G, Brock K, Mollan SP, Sinclair AJ. Mitchell JL, et al. Headache. 2025 Feb;65(2):258-268. doi: 10.1111/head.14897. Epub 2025 Jan 24. Headache. 2025. PMID: 39853738 Free PMC article. Clinical Trial.
Participants were treated, in randomized order, for 2 weeks with acetazolamide, amiloride, furosemide, spironolactone, and topiramate; assessment was at baseline and 2 weeks with a minimum 1-week drug washout between drugs. ...
Participants were treated, in randomized order, for 2 weeks with acetazolamide, amiloride, furosemide, spironolactone, and topiramate …
Pharmacokinetics of intranasal amiloride in healthy volunteers.
Yellepeddi VK, Battaglia M, Davies SJC, Alt J, Ashby S, Shipman P, Anderson DJ, Rower JE, Reilly C, Voight M, Mim SR. Yellepeddi VK, et al. Clin Transl Sci. 2023 Jun;16(6):1075-1084. doi: 10.1111/cts.13514. Epub 2023 Mar 27. Clin Transl Sci. 2023. PMID: 36932683 Free PMC article. Clinical Trial.
An intranasal formulation of amiloride will be highly beneficial to treat acute panic attacks due to advantages such as the rapid onset of action and patient compliance. The aim of this single-center, open-label trial was to evaluate the basic pharmacokinetics (PKs) and sa …
An intranasal formulation of amiloride will be highly beneficial to treat acute panic attacks due to advantages such as the rapid ons …
Amiloride evokes significant natriuresis and weight loss in kidney transplant recipients with and without albuminuria.
Hinrichs GR, Nielsen JR, Birn H, Bistrup C, Jensen BL. Hinrichs GR, et al. Am J Physiol Renal Physiol. 2023 Oct 1;325(4):F426-F435. doi: 10.1152/ajprenal.00108.2023. Epub 2023 Aug 10. Am J Physiol Renal Physiol. 2023. PMID: 37560772 Free article. Clinical Trial.
KTRs with and without albuminuria (albumin-to-creatinine ratio > 300 mg/g, n = 7, and <30 mg/g, n = 7, respectively) were included and ingested a diet with fixed Na(+) content (150 mmol/day) for 5 days. On the last day, amiloride at 10 mg was administered twice. Body …
KTRs with and without albuminuria (albumin-to-creatinine ratio > 300 mg/g, n = 7, and <30 mg/g, n = 7, respectively) were included and …
Effects of chlorthalidone plus amiloride compared with amlodipine on short-term blood pressure variability in individuals with hypertension and obstructive sleep apnea: a randomized controlled trial.
Lucca MB, Jorge JA, Cichelero FT, Martinez D, Borges RB, Hirakata VN, Fuchs FD, Fuchs SC. Lucca MB, et al. Blood Press Monit. 2023 Dec 1;28(6):289-294. doi: 10.1097/MBP.0000000000000663. Epub 2023 Jul 12. Blood Press Monit. 2023. PMID: 37466401 Free PMC article. Clinical Trial.
OBJECTIVE: To compare the effects of chlortalidone plus amiloride and amlodipine on blood pressure (BP) variability in patients with hypertension and obstructive sleep apnea syndrome (OSA). ...RESULTS: The study included 65 patients, with 33 assigned to the chlortalidone p …
OBJECTIVE: To compare the effects of chlortalidone plus amiloride and amlodipine on blood pressure (BP) variability in patients with …
Effectiveness of Chlorthalidone Plus Amiloride for the Prevention of Hypertension: The PREVER-Prevention Randomized Clinical Trial.
Fuchs SC, Poli-de-Figueiredo CE, Figueiredo Neto JA, Scala LC, Whelton PK, Mosele F, de Mello RB, Vilela-Martin JF, Moreira LB, Chaves H, Mota Gomes M, de Sousa MR, Silva RP, Castro I, Cesarino EJ, Jardim PC, Alves JG, Steffens AA, Brandão AA, Consolim-Colombo FM, de Alencastro PR, Neto AA, Nóbrega AC, Franco RS, Sobral Filho DC, Bordignon A, Nobre F, Schlatter R, Gus M, Fuchs FC, Berwanger O, Fuchs FD. Fuchs SC, et al. J Am Heart Assoc. 2016 Dec 13;5(12):e004248. doi: 10.1161/JAHA.116.004248. J Am Heart Assoc. 2016. PMID: 27965209 Free PMC article. Clinical Trial.
Participants with prehypertension who were aged 30 to 70 years and who did not reach optimal blood pressure after 3 months of lifestyle intervention were randomized to a chlorthalidone/amiloride combination pill or placebo and were evaluated every 3 months during 18 months …
Participants with prehypertension who were aged 30 to 70 years and who did not reach optimal blood pressure after 3 months of lifestyle inte …
Effectiveness of chlorthalidone/amiloride versus losartan in patients with stage I hypertension and diabetes mellitus: results from the PREVER-treatment randomized controlled trial.
Fuchs FD, Scala LCN, Vilela-Martin JF, Whelton PK, Poli-de-Figueiredo CE, Pereira E Silva R, Gus M, Bortolotto LA, Consolim-Colombo FM, Schlatter RP, Cesarino JE, Castro I, Figueiredo Neto JA, Chaves H, Steffens AA, Alves JG, Brandão AA, de Sousa MR, Jardim PC, Moreira LB, Franco RS, Gomes MM, Afiune Neto A, Fuchs FC, Sobral Filho DC, Nóbrega AC, Nobre F, Berwanger O, Fuchs SC. Fuchs FD, et al. Acta Diabetol. 2021 Feb;58(2):215-220. doi: 10.1007/s00592-020-01611-8. Epub 2020 Oct 13. Acta Diabetol. 2021. PMID: 33047257 Clinical Trial.
AIMS: To compare the blood pressure (BP)-lowering efficacy of a chlorthalidone/amiloride combination pill with losartan, during initial management of JNC 7 Stage I hypertension in patients with type 2 diabetes mellitus. ...CONCLUSIONS: Treatment of hypertension based on a …
AIMS: To compare the blood pressure (BP)-lowering efficacy of a chlorthalidone/amiloride combination pill with losartan, during initi …
420 results