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Year Number of Results
1989 2
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1999 7
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2002 13
2003 15
2004 24
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2008 25
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2012 27
2013 29
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425 results

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Page 1
Cognitive enhancement effects of stimulants: a randomized controlled trial testing methylphenidate, modafinil, and caffeine.
Repantis D, Bovy L, Ohla K, Kühn S, Dresler M. Repantis D, et al. Psychopharmacology (Berl). 2021 Feb;238(2):441-451. doi: 10.1007/s00213-020-05691-w. Epub 2020 Nov 17. Psychopharmacology (Berl). 2021. PMID: 33201262 Free PMC article. Clinical Trial.
METHODS: We conducted a pilot study with three arms in which male participants received placebo and one of three stimulants (caffeine, methylphenidate, modafinil) and assessed cognitive performance with a test battery that captures various cognitive domains. ...Methylpheni …
METHODS: We conducted a pilot study with three arms in which male participants received placebo and one of three stimulants (caffeine, methy …
Cognitive enhancement: Effects of methylphenidate, modafinil, and caffeine on latent memory and resting state functional connectivity in healthy adults.
Becker M, Repantis D, Dresler M, Kühn S. Becker M, et al. Hum Brain Mapp. 2022 Oct 1;43(14):4225-4238. doi: 10.1002/hbm.25949. Epub 2022 Jun 7. Hum Brain Mapp. 2022. PMID: 35670369 Free PMC article. Clinical Trial.
Stimulants like methylphenidate, modafinil, and caffeine have repeatedly shown to enhance cognitive processes such as attention and memory. ...Here, we utilized behavioral and resting-state fMRI data from a double-blind randomized placebocontrolled study of methylphenidate …
Stimulants like methylphenidate, modafinil, and caffeine have repeatedly shown to enhance cognitive processes such as attention and m …
Pitolisant versus placebo or modafinil in patients with narcolepsy: a double-blind, randomised trial.
Dauvilliers Y, Bassetti C, Lammers GJ, Arnulf I, Mayer G, Rodenbeck A, Lehert P, Ding CL, Lecomte JM, Schwartz JC; HARMONY I study group. Dauvilliers Y, et al. Lancet Neurol. 2013 Nov;12(11):1068-75. doi: 10.1016/S1474-4422(13)70225-4. Epub 2013 Oct 7. Lancet Neurol. 2013. PMID: 24107292 Clinical Trial.
Using a computer-generated randomisation sequence, we randomly allocated patients to receive pitolisant, modafinil, or placebo (1:1:1). Treatment lasted 8 weeks: 3 weeks of flexible dosing according to investigator's judgment (10 mg, 20 mg, or 40 mg a day of pitolisant; 10 …
Using a computer-generated randomisation sequence, we randomly allocated patients to receive pitolisant, modafinil, or placebo (1:1:1 …
Modafinil Versus Amphetamine-Dextroamphetamine For Idiopathic Hypersomnia and Narcolepsy Type 2: A Randomized, Blinded, Non-inferiority Trial.
Trotti LM, Blake T, Hoque R, Rye DB, Sharma S, Bliwise DL. Trotti LM, et al. CNS Drugs. 2024 Nov;38(11):909-920. doi: 10.1007/s40263-024-01122-y. Epub 2024 Sep 21. CNS Drugs. 2024. PMID: 39306601 Free PMC article. Clinical Trial.
We performed a randomized, fully blinded, noninferiority trial of modafinil versus amphetamine-dextroamphetamine in these disorders. METHODS: Forty-four adults were randomized to modafinil or amphetamine-dextroamphetamine, individually titrated to a maximum of mo …
We performed a randomized, fully blinded, noninferiority trial of modafinil versus amphetamine-dextroamphetamine in these disorders. …
Orexin 2 receptor-selective agonist danavorexton (TAK-925) promotes wakefulness in non-human primates and healthy individuals.
Evans R, Kimura H, Nakashima M, Ishikawa T, Yukitake H, Suzuki M, Hazel J, Faessel H, Wu J, Hang Y, Alexander R, Rosen L, Hartman DS, Ratti E. Evans R, et al. J Sleep Res. 2023 Oct;32(5):e13878. doi: 10.1111/jsr.13878. Epub 2023 Mar 19. J Sleep Res. 2023. PMID: 36934366 Clinical Trial.
In a phase 1b crossover, randomized, double-blind, placebo-controlled and active-controlled study in sleep-deprived healthy participants (ClinicalTrials.gov identifier: NCT03522506), modafinil 300 mg (used to demonstrate assay sensitivity) and continuous infusion of danavo …
In a phase 1b crossover, randomized, double-blind, placebo-controlled and active-controlled study in sleep-deprived healthy participants (Cl …
Comparative effectiveness of cognitive behavioural therapy, modafinil, and their combination for treating fatigue in multiple sclerosis (COMBO-MS): a randomised, statistician-blinded, parallel-arm trial.
Braley TJ, Ehde DM, Alschuler KN, Little R, Ng YT, Zhai Y, von Geldern G, Chervin RD, Conroy D, Valentine TR, Romeo AR, LaRocca N, Hamade M, Jordan A, Singh M, Segal BM, Kratz AL. Braley TJ, et al. Lancet Neurol. 2024 Nov;23(11):1108-1118. doi: 10.1016/S1474-4422(24)00354-5. Lancet Neurol. 2024. PMID: 39424559 Clinical Trial.
Change in MFIS scores from baseline to 12 weeks did not differ between groups: relative to combination therapy, the adjusted total mean difference in MFIS change score was 1.88 (95% CI -2.21 to 5.96) for CBT and 1.20 (-2.83 to 5.23) for modafinil. Most common adverse event …
Change in MFIS scores from baseline to 12 weeks did not differ between groups: relative to combination therapy, the adjusted total mean diff …
Methylphenidate versus placebo for fatigue in patients with advanced cancer: the MePFAC randomised controlled trial.
Stone P, Minton O, Richardson A, Buckle P, Enayat ZE, Marston L, Freemantle N. Stone P, et al. Health Technol Assess. 2025 Jul;29(36):1-47. doi: 10.3310/GJPS6321. Health Technol Assess. 2025. PMID: 40755226 Free PMC article. Clinical Trial.
PRINCIPAL EXCLUSIONS: Pregnancy; glaucoma; pheochromocytoma; planned general anaesthesia; hyperthyroidism; severe psychiatric disorders; hypertension; severe cardiovascular disorders; cerebrovascular disorders; anaemia; thrombocytopenia; leucopenia; infection; renal or liver impa …
PRINCIPAL EXCLUSIONS: Pregnancy; glaucoma; pheochromocytoma; planned general anaesthesia; hyperthyroidism; severe psychiatric disorders; hyp …
Adjunct armodafinil improves wakefulness and memory in obstructive sleep apnea/hypopnea syndrome.
Hirshkowitz M, Black JE, Wesnes K, Niebler G, Arora S, Roth T. Hirshkowitz M, et al. Respir Med. 2007 Mar;101(3):616-27. doi: 10.1016/j.rmed.2006.06.007. Epub 2006 Aug 14. Respir Med. 2007. PMID: 16908126 Free article. Clinical Trial.
OBJECTIVE: Armodafinil is the R-enantiomer of racemic modafinil and has a significantly longer half-life than the S-enantiomer. ...Armodafinil was well tolerated....
OBJECTIVE: Armodafinil is the R-enantiomer of racemic modafinil and has a significantly longer half-life than the S-enantiomer …
Cocaine craving and use during pharmacotherapy trials for cocaine use disorder: A multi-trajectory analysis.
Mojtabai R, Susukida R, Farokhnia M, Nguyen TQ, Leggio L, Bergeria C, Dunn KE, Aminesmaeili M. Mojtabai R, et al. Drug Alcohol Depend. 2025 Oct 1;275:112841. doi: 10.1016/j.drugalcdep.2025.112841. Epub 2025 Aug 15. Drug Alcohol Depend. 2025. PMID: 40845736 Free PMC article. Clinical Trial.
METHODS: In 1070 participants from 6 randomized controlled trials testing selegiline, baclofen, cabergoline, modafinil, reserpine, and tiagabine, we used multi-trajectory modeling to identify joint trajectories of weekly-measured cocaine craving and use. ...Compared to the …
METHODS: In 1070 participants from 6 randomized controlled trials testing selegiline, baclofen, cabergoline, modafinil, reserpine, an …
Efficacy of Treatment With Armodafinil for Cancer-Related Fatigue in Patients With High-grade Glioma: A Phase 3 Randomized Clinical Trial.
Porter AB, Liu H, Kohli S, Cerhan JL, Sloan J, McMurray RP, Le-Rademacher J, Loprinzi CL, Villano JL, Kizilbash SH, Mehta MP, Jaeckle KA, Brown PD. Porter AB, et al. JAMA Oncol. 2022 Feb 1;8(2):259-267. doi: 10.1001/jamaoncol.2021.5948. JAMA Oncol. 2022. PMID: 34882169 Free PMC article. Clinical Trial.
INTERVENTIONS: Patients were randomized to 150 mg of armodafinil, 250 mg of armodafinil, or placebo for a total of 8 weeks with assessments at weeks 4 and 8. ...There was no difference in the proportion of patients who achieved clinically meaningful fatigue reductio …
INTERVENTIONS: Patients were randomized to 150 mg of armodafinil, 250 mg of armodafinil, or placebo for a total of 8 weeks wit …
425 results