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1997 1
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2009 3
2010 7
2011 7
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2015 6
2016 6
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2018 4
2019 1
2020 1
2021 0
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Efficacy and Tolerability of Asenapine Compared with Olanzapine in Borderline Personality Disorder: An Open-Label Randomized Controlled Trial.
Bozzatello P, Rocca P, Uscinska M, Bellino S. Bozzatello P, et al. CNS Drugs. 2017 Sep;31(9):809-819. doi: 10.1007/s40263-017-0458-4. CNS Drugs. 2017. PMID: 28741044 Free article. Clinical Trial.
CONCLUSIONS: Asenapine and olanzapine were demonstrated to have a similar efficacy. While asenapine was found to be more efficacious than olanzapine in treating affective instability, olanzapine was superior to asenapine in treating paranoid ideation and diss …
CONCLUSIONS: Asenapine and olanzapine were demonstrated to have a similar efficacy. While asenapine was found to be more effic …
Efficacy and Safety of Asenapine Versus Olanzapine in Combination With Divalproex for Acute Mania: A Randomized Controlled Trial.
Mahajan V, Arora M, Tandon VR, Gillani Z, Praharaj SK. Mahajan V, et al. J Clin Psychopharmacol. 2019 Jul/Aug;39(4):305-311. doi: 10.1097/JCP.0000000000001064. J Clin Psychopharmacol. 2019. PMID: 31205195 Clinical Trial.
The objective of the study was to compare the efficacy and safety of asenapine and olanzapine when used in combination with divalproex in patients with acute mania. ...Higher weight gain, increased sleep and appetite, and tremors were seen in the olanzapine-treated patient …
The objective of the study was to compare the efficacy and safety of asenapine and olanzapine when used in combination with divalproe …
Asenapine pharmacokinetics and tolerability in a pediatric population.
Dogterom P, Riesenberg R, de Greef R, Dennie J, Johnson M, Pilla Reddy V, Miltenburg AM, Findling RL, Jakate A, Carrothers TJ, Troyer MD. Dogterom P, et al. Drug Des Devel Ther. 2018 Aug 30;12:2677-2693. doi: 10.2147/DDDT.S171475. eCollection 2018. Drug Des Devel Ther. 2018. PMID: 30214156 Free PMC article. Clinical Trial.
RESULTS: The PK of asenapine showed rapid absorption (T(max) ~1 hour) with an apparent terminal half-life between 16 and 32 hours. ...Simulation-based estimates of C(max) and AUC(0-12) were similar for pediatric and adult patients; age, body-mass index, race, and sex were …
RESULTS: The PK of asenapine showed rapid absorption (T(max) ~1 hour) with an apparent terminal half-life between 16 and 32 hours. .. …
Quantification of asenapine and three metabolites in human plasma using liquid chromatography-tandem mass spectrometry with automated solid-phase extraction: application to a phase I clinical trial with asenapine in healthy male subjects.
de Boer T, Meulman E, Meijering H, Wieling J, Dogterom P, Lass H. de Boer T, et al. Biomed Chromatogr. 2012 Feb;26(2):156-65. doi: 10.1002/bmc.1640. Epub 2011 May 6. Biomed Chromatogr. 2012. PMID: 21557265 Clinical Trial.
The development and validation of methods for determining concentrations of the antipsychotic drug asenapine (ASE) and three of its metabolites [N-desmethylasenapine (DMA), asenapine-N(+) -glucuronide (ASG) and 11-O-sulfate-asenapine (OSA)] in human plasma us …
The development and validation of methods for determining concentrations of the antipsychotic drug asenapine (ASE) and three of its m …
Efficacy and tolerability of asenapine in acute schizophrenia: a placebo- and risperidone-controlled trial.
Potkin SG, Cohen M, Panagides J. Potkin SG, et al. J Clin Psychiatry. 2007 Oct;68(10):1492-500. doi: 10.4088/jcp.v68n1004. J Clin Psychiatry. 2007. PMID: 17960962 Clinical Trial.

Compared with placebo, improvements on CGI-S and PANSS positive subscale scores were significantly greater with both asenapine (p < .01 and p = .01) and risperidone (p < .005 and p < .05). ...CONCLUSION: Asenapine was effective and well tolerated in

Compared with placebo, improvements on CGI-S and PANSS positive subscale scores were significantly greater with both asenapine
Asenapine: Efficacy and safety of 5 and 10mg bid in a 3-week, randomized, double-blind, placebo-controlled trial in adults with a manic or mixed episode associated with bipolar I disorder.
Landbloom RL, Mackle M, Wu X, Kelly L, Snow-Adami L, McIntyre RS, Mathews M, Hundt C. Landbloom RL, et al. J Affect Disord. 2016 Jan 15;190:103-110. doi: 10.1016/j.jad.2015.06.059. Epub 2015 Sep 25. J Affect Disord. 2016. PMID: 26496015 Clinical Trial.
Others included difference in asenapine versus placebo in the Clinical Global Impression Scale for Bipolar Severity (CGI-BP-S) and rate of YMRS responders. ...Both asenapine doses had statistically superior improvement in mean change in CGI-BP-S score …
Others included difference in asenapine versus placebo in the Clinical Global Impression Scale for Bipolar Severity (CGI-BP-S) …
Efficacy and Safety of HP-3070, an Asenapine Transdermal System, in Patients With Schizophrenia: A Phase 3, Randomized, Placebo-Controlled Study.
Citrome L, Walling DP, Zeni CM, Starling BR, Terahara T, Kuriki M, Park AS, Komaroff M. Citrome L, et al. J Clin Psychiatry. 2020 Dec 15;82(1):20m13602. doi: 10.4088/JCP.20m13602. J Clin Psychiatry. 2020. PMID: 33326711 Free article. Clinical Trial.
OBJECTIVE: Asenapine is a second-generation antipsychotic used to treat individuals with schizophrenia. This phase 3 study assessed efficacy and safety of HP-3070, an asenapine transdermal system (patch), in adults with schizophrenia. ...
OBJECTIVE: Asenapine is a second-generation antipsychotic used to treat individuals with schizophrenia. This phase 3 study assessed e …
Efficacy and safety of asenapine in a placebo- and haloperidol-controlled trial in patients with acute exacerbation of schizophrenia.
Kane JM, Cohen M, Zhao J, Alphs L, Panagides J. Kane JM, et al. J Clin Psychopharmacol. 2010 Apr;30(2):106-15. doi: 10.1097/JCP.0b013e3181d35d6b. J Clin Psychopharmacol. 2010. PMID: 20520283 Clinical Trial.
In a double-blind 6-week trial, 458 patients with acute schizophrenia were randomly assigned to fixed-dose treatment with asenapine at 5 mg twice daily (BID), asenapine at 10 mg BID, placebo, or haloperidol at 4 mg BID (to verify assay sensitivity). ...Post hoc anal …
In a double-blind 6-week trial, 458 patients with acute schizophrenia were randomly assigned to fixed-dose treatment with asenapine a …
Safety and Efficacy from an 8 Week Double-Blind Trial and a 26 Week Open-Label Extension of Asenapine in Adolescents with Schizophrenia.
Findling RL, Landbloom RP, Mackle M, Pallozzi W, Braat S, Hundt C, Wamboldt MZ, Mathews M. Findling RL, et al. J Child Adolesc Psychopharmacol. 2015 Jun;25(5):384-96. doi: 10.1089/cap.2015.0027. J Child Adolesc Psychopharmacol. 2015. PMID: 26091193 Free PMC article. Clinical Trial.
OBJECTIVE: The purpose of this study was to evaluate the safety and efficacy of asenapine in adolescents with schizophrenia. METHODS: In an 8 week, randomized, double-blind placebo-controlled trial, subjects (12-17 years of age) meeting Diagnostic and Statistical Manual of …
OBJECTIVE: The purpose of this study was to evaluate the safety and efficacy of asenapine in adolescents with schizophrenia. METHODS: …
Asenapine for the Acute Treatment of Pediatric Manic or Mixed Episode of Bipolar I Disorder.
Findling RL, Landbloom RL, Szegedi A, Koppenhaver J, Braat S, Zhu Q, Mackle M, Chang K, Mathews M. Findling RL, et al. J Am Acad Child Adolesc Psychiatry. 2015 Dec;54(12):1032-41. doi: 10.1016/j.jaac.2015.09.007. Epub 2015 Oct 24. J Am Acad Child Adolesc Psychiatry. 2015. PMID: 26598478 Free article. Clinical Trial.
The mean change from baseline in fasting insulin was larger for patients treated with asenapine than those with placebo (asenapine 2.5 mg b.i.d.: 73.375 pmol/L; asenapine 5 mg b.i.d.: 114.042 pmol/L; asenapine 10 mg b.i.d.: 59.846 pmol/L; placebo: 3.69 …
The mean change from baseline in fasting insulin was larger for patients treated with asenapine than those with placebo (asenapine
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