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1946 1
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1954 5
1955 2
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1959 4
1960 2
1962 4
1963 7
1964 20
1965 15
1966 13
1967 4
1968 20
1969 15
1970 15
1971 16
1972 21
1973 23
1974 17
1975 15
1976 15
1977 12
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1979 10
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1981 15
1982 12
1983 9
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1988 4
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1990 13
1991 10
1992 7
1993 10
1994 12
1995 6
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1997 15
1998 15
1999 15
2000 7
2001 19
2002 5
2003 10
2004 14
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2006 17
2007 13
2008 17
2009 11
2010 12
2011 12
2012 8
2013 9
2014 8
2015 9
2016 3
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795 results

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Page 1
Combination analgesics.
Beaver WT. Beaver WT. Am J Med. 1984 Sep 10;77(3A):38-53. doi: 10.1016/s0002-9343(84)80101-1. Am J Med. 1984. PMID: 6486130
Six rationales for using combination analgesics are identified, but most combinations are formulated with two rationales in mind: enhancement of analgesia and reduction of adverse effects by combining two analgesics with different mechanisms of action. Acetaminophen and aspiri …
Six rationales for using combination analgesics are identified, but most combinations are formulated with two rationales in mind: enhancemen …
Aspirin and aspirin-caffeine in postpartum pain relief.
Jain AK, McMahon FG, Ryan JR, Unger D, Richard W. Jain AK, et al. Clin Pharmacol Ther. 1978 Jul;24(1):69-75. doi: 10.1002/cpt197824169. Clin Pharmacol Ther. 1978. PMID: 350473 Clinical Trial.
In two double-blind randomized, balanced, single oral dose studies with 140 women, a combination of 800 mg aspirin and 64 mg caffeine (aspirin-caffeine) was compared to 650 mg aspirin and to placebo. ...There was no difference between analgesic …
In two double-blind randomized, balanced, single oral dose studies with 140 women, a combination of 800 mg aspirin and 64 mg caffe …
Aspirin, paracetamol (acetaminophen) and caffeine for the treatment of acute migraine attacks: A systemic review and meta-analysis of randomized placebo-controlled trials.
Diener HC, Gaul C, Lehmacher W, Weiser T. Diener HC, et al. Eur J Neurol. 2022 Jan;29(1):350-357. doi: 10.1111/ene.15103. Epub 2021 Sep 28. Eur J Neurol. 2022. PMID: 34519136
BACKGROUND AND PURPOSE: Many migraine patients rely on over-the-counter analgesics for the treatment of migraine attacks. Fixed-dose combinations of aspirin, paracetamol and caffeine (APC) have been used for treating migraine in many countries for a long time. ...
BACKGROUND AND PURPOSE: Many migraine patients rely on over-the-counter analgesics for the treatment of migraine attacks. Fixed-dose combina …
The effects of caffeine and aspirin on mood and performance.
Lieberman HR, Wurtman RJ, Emde GG, Coviella IL. Lieberman HR, et al. J Clin Psychopharmacol. 1987 Oct;7(5):315-20. J Clin Psychopharmacol. 1987. PMID: 3680601 Clinical Trial.
Caffeine, in addition to being a food constituent, is also a common analgesic adjuvant that is used in combination with aspirin in certain over-the-counter preparations. ...We observed that caffeine (64 mg), when added to aspirin (800 mg), significantl …
Caffeine, in addition to being a food constituent, is also a common analgesic adjuvant that is used in combination with aspirin …
Do codeine and caffeine enhance the analgesic effect of aspirin?--A systematic overview.
Zhang WY, Po AL. Zhang WY, et al. J Clin Pharm Ther. 1997 Apr;22(2):79-97. doi: 10.1111/j.1365-2710.1997.tb00002.x. J Clin Pharm Ther. 1997. PMID: 9373807 Review.
Caffeine did not enhance the analgesic effect of aspirin. CONCLUSION: Codeine 60 mg may produce a small increase in the analgesic effect of aspirin 650 mg. However, this effect is not clinically meaningful. Caffeine has no adjuvant analgesic effect. At …
Caffeine did not enhance the analgesic effect of aspirin. CONCLUSION: Codeine 60 mg may produce a small increase in the analge …
Use of aspirin combinations with caffeine and increasing headache frequency: a prospective population-based study.
Schramm SH, Moebus S, Özyurt Kugumcu M, Geisel MH, Obermann M, Yoon MS, Diener HC, Jöckel KH, Katsarava Z. Schramm SH, et al. Pain. 2015 Sep;156(9):1747-1754. doi: 10.1097/j.pain.0000000000000239. Pain. 2015. PMID: 26010457
Combinations of analgesics with caffeine have been discussed as bearing a risk for headache chronicity. We investigated whether aspirin with caffeine (ASA+) increases headache frequency compared with aspirin alone in migraine, tension-type headache (TT …
Combinations of analgesics with caffeine have been discussed as bearing a risk for headache chronicity. We investigated whether as …
Effect of caffeine on the bioavailability and pharmacokinetics of aspirin.
Thithapandha A. Thithapandha A. J Med Assoc Thai. 1989 Oct;72(10):562-6. J Med Assoc Thai. 1989. PMID: 2584901
The objective of this study was to determine the influence of caffeine on aspirin bioavailability and pharmacokinetics in man. Two lots of the drugs were compared. The first lot (Lot # 1), which was caffeine-free, contained 650 mg aspirin plus 60 mg ci …
The objective of this study was to determine the influence of caffeine on aspirin bioavailability and pharmacokinetics in man. …
Gastrointestinal toxicity of minor analgesics.
Duggan JM. Duggan JM. Br J Clin Pharmacol. 1980 Oct;10 Suppl 2(Suppl 2):407S-410S. doi: 10.1111/j.1365-2125.1980.tb01831.x. Br J Clin Pharmacol. 1980. PMID: 7002193 Free PMC article. Review.
1 The evidence for the risk of gastric erosions from aspirin is fragmentary. 2 Occult gastric bleeding following aspirin is poorly studied and the skewed distribution is unexplained; platelet factors may be relevant. 3 Overt gastric bleeding may follow aspirin …
1 The evidence for the risk of gastric erosions from aspirin is fragmentary. 2 Occult gastric bleeding following aspirin is po …
Caffeine in the management of patients with headache.
Lipton RB, Diener HC, Robbins MS, Garas SY, Patel K. Lipton RB, et al. J Headache Pain. 2017 Oct 24;18(1):107. doi: 10.1186/s10194-017-0806-2. J Headache Pain. 2017. PMID: 29067618 Free PMC article. Review.
Caffeinated headache medications, either alone or in combination with other treatments, are widely used by patients with headache. Clinicians should be familiar with their use as well as the chemistry, pharmacology, dietary and medical sources, clinical benefits, and poten …
Caffeinated headache medications, either alone or in combination with other treatments, are widely used by patients with headache. Cl …
Ephedrine, caffeine and aspirin: safety and efficacy for treatment of human obesity.
Daly PA, Krieger DR, Dulloo AG, Young JB, Landsberg L. Daly PA, et al. Int J Obes Relat Metab Disord. 1993 Feb;17 Suppl 1:S73-8. Int J Obes Relat Metab Disord. 1993. PMID: 8384187 Clinical Trial.
The safety and efficacy of a mixture of ephedrine (75-150mg), caffeine (150mg) and aspirin (330mg), in divided premeal doses, were investigated in 24 obese humans (mean BMI 37.0) in a randomized double blind placebo-controlled trial. ...
The safety and efficacy of a mixture of ephedrine (75-150mg), caffeine (150mg) and aspirin (330mg), in divided premeal doses, …
795 results