Model-based evaluation of the interaction between ritonavir-boosted atazanavir and rifampicin in Ugandan adults with HIV.
Kengo A, Resendiz-Galvan JE, Najjemba L, Mugerwa H, De Nicolò A, D'Avolio A, Atoyebi S, Wiesner L, Svensson EM, Waitt C, Denti P.
Kengo A, et al.
Br J Clin Pharmacol. 2025 Dec;91(12):3471-3481. doi: 10.1002/bcp.70195. Epub 2025 Aug 12.
Br J Clin Pharmacol. 2025.
PMID: 40796001
Free PMC article.
Clinical Trial.
A two-compartment model with an effect-compartment effectively described atazanavir concentrations in plasma and PBMC. Rifampicin increased atazanavir clearance threefold, while decreasing its bioavailability and absorption rate. Doubling dosing frequency of ATV/r l …
A two-compartment model with an effect-compartment effectively described atazanavir concentrations in plasma and PBMC. Rifampicin inc …