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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1990 1
1992 1
1993 1
1994 2
1995 6
1996 14
1997 32
1998 74
1999 94
2000 134
2001 189
2002 240
2003 349
2004 389
2005 521
2006 542
2007 526
2008 594
2009 539
2010 591
2011 659
2012 658
2013 625
2014 674
2015 633
2016 611
2017 626
2018 630
2019 636
2020 593
2021 623
2022 547
2023 554
2024 373

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11,853 results

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Page 1
Comparative efficacy and safety among high-intensity statins. Systematic Review and Meta-Analysis.
Jaam M, Al-Naimi HN, Haddad MM, Abushanab D, Al-Badriyeh D. Jaam M, et al. J Comp Eff Res. 2023 Mar;12(3):e220163. doi: 10.57264/cer-2022-0163. Epub 2023 Feb 27. J Comp Eff Res. 2023. PMID: 36847307 Free PMC article. Review.
All statins were observed to have similar adverse drug reactions (ADRs), although higher dosages were associated with more ADRs. Based on a pooled quantitative analysis of atorvastatin 80 mg versus rosuvastatin 40 mg, rosuvastatin was statistically more effective in reduci …
All statins were observed to have similar adverse drug reactions (ADRs), although higher dosages were associated with more ADRs. Based on a …
Atorvastatin inhibits neuronal apoptosis via activating cAMP/PKA/p-CREB/BDNF pathway in hypoxic-ischemic neonatal rats.
Yu L, Liu S, Zhou R, Sun H, Su X, Liu Q, Li S, Ying J, Zhao F, Mu D, Qu Y. Yu L, et al. FASEB J. 2022 Apr;36(4):e22263. doi: 10.1096/fj.202101654RR. FASEB J. 2022. PMID: 35303316
Furthermore, inhibition of cAMP or BDNF attenuated the effect of atorvastatin on the reduction of neuronal apoptosis, suggesting that atorvastatin inhibits HIBD-induced neuronal apoptosis and alleviates brain injury in neonatal rats mainly by activating the cAMP/PKA …
Furthermore, inhibition of cAMP or BDNF attenuated the effect of atorvastatin on the reduction of neuronal apoptosis, suggesting that …
Safety and Efficacy of Atorvastatin for Chronic Subdural Hematoma in Chinese Patients: A Randomized ClinicalTrial.
Jiang R, Zhao S, Wang R, Feng H, Zhang J, Li X, Mao Y, Yuan X, Fei Z, Zhao Y, Yu X, Poon WS, Zhu X, Liu N, Kang D, Sun T, Jiao B, Liu X, Yu R, Zhang J, Gao G, Hao J, Su N, Yin G, Zhu X, Lu Y, Wei J, Hu J, Hu R, Li J, Wang D, Wei H, Tian Y, Lei P, Dong JF, Zhang J. Jiang R, et al. JAMA Neurol. 2018 Nov 1;75(11):1338-1346. doi: 10.1001/jamaneurol.2018.2030. JAMA Neurol. 2018. PMID: 30073290 Free PMC article. Clinical Trial.
INTERVENTIONS: Patients were randomly assigned to receive either 20 mg of atorvastatin or placebo daily for 8 weeks and were followed up for an additional 16 weeks. ...The baseline HV and clinical presentations were similar between patients who were taking atorvastatin
INTERVENTIONS: Patients were randomly assigned to receive either 20 mg of atorvastatin or placebo daily for 8 weeks and were followed …
Statins aggravate insulin resistance through reduced blood glucagon-like peptide-1 levels in a microbiota-dependent manner.
She J, Tuerhongjiang G, Guo M, Liu J, Hao X, Guo L, Liu N, Xi W, Zheng T, Du B, Lou B, Gao X, Yuan X, Yu Y, Zhang Y, Gao F, Zhuo X, Xiong Y, Zhang X, Yu J, Yuan Z, Wu Y. She J, et al. Cell Metab. 2024 Feb 6;36(2):408-421.e5. doi: 10.1016/j.cmet.2023.12.027. Cell Metab. 2024. PMID: 38325336
To investigate whether the gut microbiome and its metabolites contribute to statin-associated glucose intolerance, we recruited 30 patients with atorvastatin and 10 controls, followed up for 16 weeks, and found a decreased abundance of the genus Clostridium in feces and al …
To investigate whether the gut microbiome and its metabolites contribute to statin-associated glucose intolerance, we recruited 30 patients …
Atorvastatin rescues hyperhomocysteinemia-induced cognitive deficits and neuroinflammatory gene changes.
Weekman EM, Johnson SN, Rogers CB, Sudduth TL, Xie K, Qiao Q, Fardo DW, Bottiglieri T, Wilcock DM. Weekman EM, et al. J Neuroinflammation. 2023 Sep 1;20(1):199. doi: 10.1186/s12974-023-02883-x. J Neuroinflammation. 2023. PMID: 37658433 Free PMC article.
Microglia in HHcy mice with atorvastatin were trending towards fewer processes compared to control with atorvastatin, but there were no atorvastatin effects on astrocyte end feet. ...Finally, atorvastatin treatment in HHcy mice led to improved cognitio …
Microglia in HHcy mice with atorvastatin were trending towards fewer processes compared to control with atorvastatin, but ther …
Atorvastatin Ester Regulates Lipid Metabolism in Hyperlipidemia Rats via the PPAR-signaling Pathway and HMGCR Expression in the Liver.
Hu N, Chen C, Wang J, Huang J, Yao D, Li C. Hu N, et al. Int J Mol Sci. 2021 Oct 14;22(20):11107. doi: 10.3390/ijms222011107. Int J Mol Sci. 2021. PMID: 34681767 Free PMC article.
Atorvastatin ester (Ate) is a structural trim of atorvastatin that can regulate hyperlipidemia. ...
Atorvastatin ester (Ate) is a structural trim of atorvastatin that can regulate hyperlipidemia. ...
Atorvastatin-pretreated mesenchymal stem cell-derived extracellular vesicles promote cardiac repair after myocardial infarction via shifting macrophage polarization by targeting microRNA-139-3p/Stat1 pathway.
Ning Y, Huang P, Chen G, Xiong Y, Gong Z, Wu C, Xu J, Jiang W, Li X, Tang R, Zhang L, Hu M, Xu J, Xu J, Qian H, Jin C, Yang Y. Ning Y, et al. BMC Med. 2023 Mar 16;21(1):96. doi: 10.1186/s12916-023-02778-x. BMC Med. 2023. PMID: 36927608 Free PMC article.
BACKGROUND: Extracellular vesicles (EVs) derived from bone marrow mesenchymal stem cells (MSCs) pretreated with atorvastatin (ATV) (MSC(ATV)-EV) have a superior cardiac repair effect on acute myocardial infarction (AMI). ...
BACKGROUND: Extracellular vesicles (EVs) derived from bone marrow mesenchymal stem cells (MSCs) pretreated with atorvastatin (ATV) (M …
Atorvastatin rescues vascular endothelial injury in hypertension by WWP2-mediated ubiquitination and degradation of ATP5A.
Yin Z, You S, Zhang S, Zhang L, Wu B, Huang X, Lu S, Cao L, Zhang Y, Li D, Zhang X, Liu J, Sun Y, Zhang N. Yin Z, et al. Biomed Pharmacother. 2023 Oct;166:115228. doi: 10.1016/j.biopha.2023.115228. Epub 2023 Aug 7. Biomed Pharmacother. 2023. PMID: 37557013 Free article.
As a widely used lipid-lowering drug in clinical practice, atorvastatin is widely recognized for its role in protecting vascular endothelium in the cardiovascular system. However, a clear mechanistic understanding of its action is lacking. Here, we found that atorvastat
As a widely used lipid-lowering drug in clinical practice, atorvastatin is widely recognized for its role in protecting vascular endo …
Cholesterol-absorbed in thought.
Tietge UJ. Tietge UJ. Curr Opin Lipidol. 2016 Apr;27(2):202-3. doi: 10.1097/MOL.0000000000000283. Curr Opin Lipidol. 2016. PMID: 26959709 No abstract available.
Considering Pharmaceutical Rebates.
Johansen ME, Richardson CR. Johansen ME, et al. JAMA Intern Med. 2018 Aug 1;178(8):1139-1140. doi: 10.1001/jamainternmed.2018.3044. JAMA Intern Med. 2018. PMID: 30083736 No abstract available.
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