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Page 1
Effect of Sunscreen Application on Plasma Concentration of Sunscreen Active Ingredients: A Randomized Clinical Trial.
Matta MK, Florian J, Zusterzeel R, Pilli NR, Patel V, Volpe DA, Yang Y, Oh L, Bashaw E, Zineh I, Sanabria C, Kemp S, Godfrey A, Adah S, Coelho S, Wang J, Furlong LA, Ganley C, Michele T, Strauss DG. Matta MK, et al. JAMA. 2020 Jan 21;323(3):256-267. doi: 10.1001/jama.2019.20747. JAMA. 2020. PMID: 31961417 Free PMC article. Clinical Trial.
OBJECTIVE: To assess the systemic absorption and pharmacokinetics of the 6 active ingredients (avobenzone, oxybenzone, octocrylene, homosalate, octisalate, and octinoxate) in 4 sunscreen products under single- and maximal-use conditions. ...MAIN …
OBJECTIVE: To assess the systemic absorption and pharmacokinetics of the 6 active ingredients (avobenzone, oxybenzone, octocry …
Sunscreens.
[No authors listed] [No authors listed] 2026 Feb 15. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. 2026 Feb 15. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. PMID: 41730063 Free Books & Documents. Review.
Most organic chemical sunscreens are detectable in breastmilk, but the amounts that an infant would ingest are usually lower than current limits of concern.[1-5] Products containing octinoxate, enzacamene, and especially oxybenzone should probably be avoided during …
Most organic chemical sunscreens are detectable in breastmilk, but the amounts that an infant would ingest are usually lower than current li …
Mechanistic Skin Modeling of Plasma Concentrations of Sunscreen Active Ingredients Following Facial Application.
Hamadeh A, Nash JF, Bialk H, Styczynski P, Troutman J, Edginton A. Hamadeh A, et al. J Pharm Sci. 2024 Mar;113(3):806-825. doi: 10.1016/j.xphs.2023.09.017. Epub 2023 Sep 26. J Pharm Sci. 2024. PMID: 37769994 Free article.
Building on earlier methods for predicting dermal disposition, a mechanistic model was developed to simulate plasma concentrations of seven organic sunscreen active ingredients: avobenzone, ensulizole, homosalate, octinoxate, octisalate, octocrylene, a …
Building on earlier methods for predicting dermal disposition, a mechanistic model was developed to simulate plasma concentrations of seven …
In Vitro Testing of Sunscreens for Dermal Absorption: Method Comparison and Rank Order Correlation with In Vivo Absorption.
Yang Y, Ako-Adounvo AM, Wang J, Coelho SG, Adah SA, Matta MK, Strauss D, Michele TM, Wang J, Faustino PJ, O'Connor T, Ashraf M. Yang Y, et al. AAPS PharmSciTech. 2022 Apr 22;23(5):121. doi: 10.1208/s12249-022-02275-z. AAPS PharmSciTech. 2022. PMID: 35459978
The IVPT was used to evaluate dermal absorption of six UV filters (avobenzone, homosalate, octinoxate, octisalate, octocrylene, and oxybenzone) in commercial sunscreens. ...Rank orders of the cumulative in vitro skin permeation and the in vivo A …
The IVPT was used to evaluate dermal absorption of six UV filters (avobenzone, homosalate, octinoxate, octisalate …
In vitro metabolism of sunscreen compounds by liquid chromatography/high-resolution tandem mass spectrometry.
Guesmi A, Ohlund L, Sleno L. Guesmi A, et al. Rapid Commun Mass Spectrom. 2020 Apr 30;34(8):e8679. doi: 10.1002/rcm.8679. Rapid Commun Mass Spectrom. 2020. PMID: 31782973
METHODS: Liquid chromatography coupled to high-resolution tandem mass spectrometry (LC/HRMS/MS) was employed to evaluate the oxidative metabolism and, specifically, the formation of reactive metabolites of six active ingredients commonly used in sunscreen formulations: oxybenz …
METHODS: Liquid chromatography coupled to high-resolution tandem mass spectrometry (LC/HRMS/MS) was employed to evaluate the oxidative metab …
Quantitation of Canadian organic ultraviolet filters using polarity switching and ultra-high performance liquid chromatography-tandem mass spectrometry.
Brown AK, Farenhorst A. Brown AK, et al. J Chromatogr A. 2023 Aug 16;1704:464132. doi: 10.1016/j.chroma.2023.464132. Epub 2023 Jun 4. J Chromatogr A. 2023. PMID: 37302251
This study developed a unified method to quantify eight UVFs (avobenzone, dioxybenzone, homosalate, octinoxate, octisalate, octocrylene, oxybenzone, and sulisobenzone) by solid phase extraction and ultra-high performance liquid chromatography-ta …
This study developed a unified method to quantify eight UVFs (avobenzone, dioxybenzone, homosalate, octinoxate, octi …
Practical application of the interim internal threshold of toxicological concern (iTTC): a case study based on clinical data.
Najjar A, Ellison CA, Gregoire S, Hewitt NJ. Najjar A, et al. Arch Toxicol. 2023 Jan;97(1):155-164. doi: 10.1007/s00204-022-03371-6. Epub 2022 Sep 23. Arch Toxicol. 2023. PMID: 36149470 Free PMC article.
The case study uses a theoretical scenario where there are no systemic toxicity data for the case study chemicals (avobenzone, oxybenzone, octocrylene, homosalate, octisalate, octinoxate, and ecamsule). Human dermal pharmacokinetic data followin …
The case study uses a theoretical scenario where there are no systemic toxicity data for the case study chemicals (avobenzone, oxy …
Comparison between endocrine activity assessed using ToxCast/Tox21 database and human plasma concentration of sunscreen active ingredients/UV filters.
Onyango DO, Selman BG, Rose JL, Ellison CA, Nash JF. Onyango DO, et al. Toxicol Sci. 2023 Oct 30;196(1):25-37. doi: 10.1093/toxsci/kfad082. Toxicol Sci. 2023. PMID: 37561120 Free PMC article.
The ToxCast/Tox21 program, that is, CompTox, is a high-throughput in vitro screening database of chemicals that identify adverse outcome pathways, key events, and ED potential of chemicals. Using the ToxCast/Tox21 database, octisalate, homosalate, octocrylene, ox …
The ToxCast/Tox21 program, that is, CompTox, is a high-throughput in vitro screening database of chemicals that identify adverse outcome pat …
Assessing the hepatic metabolism of six sunscreen ultraviolet filters: In vitro-in vivo extrapolation approach using human liver microsomes and hepatic parameter predictions for exposure risk assessment.
Baviera GS, Poli VR, Oka-Duarte L, Santos Barbetta MF, Moraes de Oliveira AR. Baviera GS, et al. Biochem Pharmacol. 2026 Feb;244:117564. doi: 10.1016/j.bcp.2025.117564. Epub 2025 Nov 28. Biochem Pharmacol. 2026. PMID: 41319926
The present work investigates the in vitro hepatic metabolism of six commonly used sunscreen UV filters: oxybenzone, avobenzone, octocrylene, octinoxate, octisalate, and homosalate, using human liver microsomes. ...Additionally, reaction phenoty …
The present work investigates the in vitro hepatic metabolism of six commonly used sunscreen UV filters: oxybenzone, avobenzone …
The dual challenge of FDA-evaluated non-GRASE UV filters: Photostability and systemic absorption - A path toward safer and more effective sunscreens.
Safian MT, Raja PB, Muniandy K, Karam Chand NS, Mohd Sahak MZ, Shaharudin S, Mohamad Ibrahim MN. Safian MT, et al. Int J Pharm. 2025 Jul 25;680:125790. doi: 10.1016/j.ijpharm.2025.125790. Epub 2025 May 30. Int J Pharm. 2025. PMID: 40451593 Review.
Category III Non-GRASE (Generally Recognized as Safe and Effective) UV filters (UVFs), such as avobenzone, octocrylene, oxybenzone, octinoxate, octisalate, and homosalate, face two significant challenges: photodegradation and systemic absorption …
Category III Non-GRASE (Generally Recognized as Safe and Effective) UV filters (UVFs), such as avobenzone, octocrylene, oxybenzone …