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Page 1
Effect of Sunscreen Application on Plasma Concentration of Sunscreen Active Ingredients: A Randomized Clinical Trial.
Matta MK, Florian J, Zusterzeel R, Pilli NR, Patel V, Volpe DA, Yang Y, Oh L, Bashaw E, Zineh I, Sanabria C, Kemp S, Godfrey A, Adah S, Coelho S, Wang J, Furlong LA, Ganley C, Michele T, Strauss DG. Matta MK, et al. JAMA. 2020 Jan 21;323(3):256-267. doi: 10.1001/jama.2019.20747. JAMA. 2020. PMID: 31961417 Free PMC article. Clinical Trial.
OBJECTIVE: To assess the systemic absorption and pharmacokinetics of the 6 active ingredients (avobenzone, oxybenzone, octocrylene, homosalate, octisalate, and octinoxate) in 4 sunscreen products under single- and maximal-use conditions. ...MAIN OUTCOMES AND …
OBJECTIVE: To assess the systemic absorption and pharmacokinetics of the 6 active ingredients (avobenzone, oxybenzone, octocrylene, …
Development of a novel rinse-off method for improved sunscreen exposure assessment.
Saxe JK, Dean S, Jones RL, Mullins LA, Reynertson KA. Saxe JK, et al. Integr Environ Assess Manag. 2021 Sep;17(5):961-966. doi: 10.1002/ieam.4451. Epub 2021 Jun 14. Integr Environ Assess Manag. 2021. PMID: 34002489 Free PMC article.
To improve the accuracy of exposure estimates and thereby develop more robust risk assessments, we measured the amount of the UVFs, avobenzone, homosalate, octisalate, octocrylene, and oxybenzone released to seawater from four sunscreen products (two lotions, …
To improve the accuracy of exposure estimates and thereby develop more robust risk assessments, we measured the amount of the UVFs, avobe
Occurrence of major organic UV filters in aquatic environments and their endocrine disruption potentials: A mini-review.
Kwon B, Choi K. Kwon B, et al. Integr Environ Assess Manag. 2021 Sep;17(5):940-950. doi: 10.1002/ieam.4449. Epub 2021 Jun 11. Integr Environ Assess Manag. 2021. PMID: 33991024 Review.
In the present study, we chose other major organic UV filters, such as avobenzone (AVB), homosalate (HS), octisalate (OS), and octocrylene (OC), and reviewed information on their use, environmental occurrences, and endocrine disruption effects, available to d …
In the present study, we chose other major organic UV filters, such as avobenzone (AVB), homosalate (HS), octisalate (O …
Mechanistic Skin Modeling of Plasma Concentrations of Sunscreen Active Ingredients Following Facial Application.
Hamadeh A, Nash JF, Bialk H, Styczynski P, Troutman J, Edginton A. Hamadeh A, et al. J Pharm Sci. 2024 Mar;113(3):806-825. doi: 10.1016/j.xphs.2023.09.017. Epub 2023 Sep 26. J Pharm Sci. 2024. PMID: 37769994 Free article.
Building on earlier methods for predicting dermal disposition, a mechanistic model was developed to simulate plasma concentrations of seven organic sunscreen active ingredients: avobenzone, ensulizole, homosalate, octinoxate, octisalate, octocrylene, and oxyb …
Building on earlier methods for predicting dermal disposition, a mechanistic model was developed to simulate plasma concentrations of seven …
In Vitro Testing of Sunscreens for Dermal Absorption: Method Comparison and Rank Order Correlation with In Vivo Absorption.
Yang Y, Ako-Adounvo AM, Wang J, Coelho SG, Adah SA, Matta MK, Strauss D, Michele TM, Wang J, Faustino PJ, O'Connor T, Ashraf M. Yang Y, et al. AAPS PharmSciTech. 2022 Apr 22;23(5):121. doi: 10.1208/s12249-022-02275-z. AAPS PharmSciTech. 2022. PMID: 35459978
The IVPT was used to evaluate dermal absorption of six UV filters (avobenzone, homosalate, octinoxate, octisalate, octocrylene, and oxybenzone) in commercial sunscreens. ...Rank orders of the cumulative in vitro skin permeation and the in vivo AUC were found …
The IVPT was used to evaluate dermal absorption of six UV filters (avobenzone, homosalate, octinoxate, octisalate, octo …
A simple and reliable isocratic high-performance chromatographic assay for the simultaneous determination of hydrophilic benzophenone-4 and lipophilic octocrylene in sunscreens.
Pan P, Svirskis D, Waterhouse GIN, Wu Z. Pan P, et al. Int J Cosmet Sci. 2023 Aug;45(4):512-523. doi: 10.1111/ics.12860. Epub 2023 May 18. Int J Cosmet Sci. 2023. PMID: 37038989
OBJECTIVE: This work aimed to develop a simple HPLC method for the simultaneous quantitative determination of the ultraviolet (UV) filters, hydrophilic benzophenone-4 and lipophilic octocrylene, in the presence of three other commonly used UV filters, avobenzone, octisa
OBJECTIVE: This work aimed to develop a simple HPLC method for the simultaneous quantitative determination of the ultraviolet (UV) filters, …
In vitro metabolism of sunscreen compounds by liquid chromatography/high-resolution tandem mass spectrometry.
Guesmi A, Ohlund L, Sleno L. Guesmi A, et al. Rapid Commun Mass Spectrom. 2020 Apr 30;34(8):e8679. doi: 10.1002/rcm.8679. Rapid Commun Mass Spectrom. 2020. PMID: 31782973
METHODS: Liquid chromatography coupled to high-resolution tandem mass spectrometry (LC/HRMS/MS) was employed to evaluate the oxidative metabolism and, specifically, the formation of reactive metabolites of six active ingredients commonly used in sunscreen formulations: oxybenzone …
METHODS: Liquid chromatography coupled to high-resolution tandem mass spectrometry (LC/HRMS/MS) was employed to evaluate the oxidative metab …
Comparison between endocrine activity assessed using ToxCast/Tox21 database and human plasma concentration of sunscreen active ingredients/UV filters.
Onyango DO, Selman BG, Rose JL, Ellison CA, Nash JF. Onyango DO, et al. Toxicol Sci. 2023 Oct 30;196(1):25-37. doi: 10.1093/toxsci/kfad082. Toxicol Sci. 2023. PMID: 37561120 Free PMC article.
The ToxCast/Tox21 program, that is, CompTox, is a high-throughput in vitro screening database of chemicals that identify adverse outcome pathways, key events, and ED potential of chemicals. Using the ToxCast/Tox21 database, octisalate, homosalate, octocrylene, oxybe …
The ToxCast/Tox21 program, that is, CompTox, is a high-throughput in vitro screening database of chemicals that identify adverse outcome pat …
Occurrence and Gas-Particle Partitioning of Organic UV-Filters in Urban Air.
Pegoraro CN, Harner T, Su K, Ahrens L. Pegoraro CN, et al. Environ Sci Technol. 2020 Oct 20;54(20):12881-12889. doi: 10.1021/acs.est.0c02665. Epub 2020 Sep 28. Environ Sci Technol. 2020. PMID: 32924452 Free article.
Seven UV compounds were analyzed by gas chromatography-tandem mass spectrometry (GC-MS/MS) with sum of concentrations (gas + particle phase) ranging from 80 to 2030 pg/m(3). Homosalate (HMS) was the most prevalent organic UV-filter in air (47% of the total concentration), …
Seven UV compounds were analyzed by gas chromatography-tandem mass spectrometry (GC-MS/MS) with sum of concentrations (gas + particle phase) …
Practical application of the interim internal threshold of toxicological concern (iTTC): a case study based on clinical data.
Najjar A, Ellison CA, Gregoire S, Hewitt NJ. Najjar A, et al. Arch Toxicol. 2023 Jan;97(1):155-164. doi: 10.1007/s00204-022-03371-6. Epub 2022 Sep 23. Arch Toxicol. 2023. PMID: 36149470 Free PMC article.
The case study uses a theoretical scenario where there are no systemic toxicity data for the case study chemicals (avobenzone, oxybenzone, octocrylene, homosalate, octisalate, octinoxate, and ecamsule). Human dermal pharmacokinetic data following single and r …
The case study uses a theoretical scenario where there are no systemic toxicity data for the case study chemicals (avobenzone, oxyben …
15 results