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Page 1
Effect of Sunscreen Application on Plasma Concentration of Sunscreen Active Ingredients: A Randomized Clinical Trial.
Matta MK, Florian J, Zusterzeel R, Pilli NR, Patel V, Volpe DA, Yang Y, Oh L, Bashaw E, Zineh I, Sanabria C, Kemp S, Godfrey A, Adah S, Coelho S, Wang J, Furlong LA, Ganley C, Michele T, Strauss DG. Matta MK, et al. JAMA. 2020 Jan 21;323(3):256-267. doi: 10.1001/jama.2019.20747. JAMA. 2020. PMID: 31961417 Free PMC article. Clinical Trial.
OBJECTIVE: To assess the systemic absorption and pharmacokinetics of the 6 active ingredients (avobenzone, oxybenzone, octocrylene, homosalate, octisalate, and octinoxate) in 4 sunscreen products under single- and maximal-use conditions. ...MAIN OUTCOM …
OBJECTIVE: To assess the systemic absorption and pharmacokinetics of the 6 active ingredients (avobenzone, oxybenzone, octocrylene …
Mechanistic Skin Modeling of Plasma Concentrations of Sunscreen Active Ingredients Following Facial Application.
Hamadeh A, Nash JF, Bialk H, Styczynski P, Troutman J, Edginton A. Hamadeh A, et al. J Pharm Sci. 2024 Mar;113(3):806-825. doi: 10.1016/j.xphs.2023.09.017. Epub 2023 Sep 26. J Pharm Sci. 2024. PMID: 37769994 Free article.
Building on earlier methods for predicting dermal disposition, a mechanistic model was developed to simulate plasma concentrations of seven organic sunscreen active ingredients: avobenzone, ensulizole, homosalate, octinoxate, octisalate, octocrylene, a …
Building on earlier methods for predicting dermal disposition, a mechanistic model was developed to simulate plasma concentrations of seven …
Development of a novel rinse-off method for improved sunscreen exposure assessment.
Saxe JK, Dean S, Jones RL, Mullins LA, Reynertson KA. Saxe JK, et al. Integr Environ Assess Manag. 2021 Sep;17(5):961-966. doi: 10.1002/ieam.4451. Epub 2021 Jun 14. Integr Environ Assess Manag. 2021. PMID: 34002489 Free PMC article.
To improve the accuracy of exposure estimates and thereby develop more robust risk assessments, we measured the amount of the UVFs, avobenzone, homosalate, octisalate, octocrylene, and oxybenzone released to seawater from four sunscreen products (two l …
To improve the accuracy of exposure estimates and thereby develop more robust risk assessments, we measured the amount of the UVFs, avobe …
A simple and reliable isocratic high-performance chromatographic assay for the simultaneous determination of hydrophilic benzophenone-4 and lipophilic octocrylene in sunscreens.
Pan P, Svirskis D, Waterhouse GIN, Wu Z. Pan P, et al. Int J Cosmet Sci. 2023 Aug;45(4):512-523. doi: 10.1111/ics.12860. Epub 2023 May 18. Int J Cosmet Sci. 2023. PMID: 37038989
OBJECTIVE: This work aimed to develop a simple HPLC method for the simultaneous quantitative determination of the ultraviolet (UV) filters, hydrophilic benzophenone-4 and lipophilic octocrylene, in the presence of three other commonly used UV filters, avobenzone, …
OBJECTIVE: This work aimed to develop a simple HPLC method for the simultaneous quantitative determination of the ultraviolet (UV) filters, …
In Vitro Testing of Sunscreens for Dermal Absorption: Method Comparison and Rank Order Correlation with In Vivo Absorption.
Yang Y, Ako-Adounvo AM, Wang J, Coelho SG, Adah SA, Matta MK, Strauss D, Michele TM, Wang J, Faustino PJ, O'Connor T, Ashraf M. Yang Y, et al. AAPS PharmSciTech. 2022 Apr 22;23(5):121. doi: 10.1208/s12249-022-02275-z. AAPS PharmSciTech. 2022. PMID: 35459978
The IVPT was used to evaluate dermal absorption of six UV filters (avobenzone, homosalate, octinoxate, octisalate, octocrylene, and oxybenzone) in commercial sunscreens. ...Additional IVPT parameters may be optimized to enhance the discriminatory power …
The IVPT was used to evaluate dermal absorption of six UV filters (avobenzone, homosalate, octinoxate, octisalate, o …
Mode of action approach supports a lack of carcinogenic potential of six organic UV filters.
Cohen SM, Boobis AR, Jacobson-Kram D, Schoeny R, Rosol TJ, Williams GM, Kaminski NE, Eichenbaum GM, Guengerich FP, Nash JF. Cohen SM, et al. Crit Rev Toxicol. 2025 Feb;55(2):248-284. doi: 10.1080/10408444.2025.2462642. Epub 2025 Apr 10. Crit Rev Toxicol. 2025. PMID: 40208192 Free article. Review.
Given these concerns with 2-year rodent carcinogenicity studies, we have developed and applied an alternative approach for supplementing existing data related to carcinogenic potential for six of the most commonly used UV filters in sunscreen products (i.e. avobenzone, ens …
Given these concerns with 2-year rodent carcinogenicity studies, we have developed and applied an alternative approach for supplementing exi …
Occurrence of major organic UV filters in aquatic environments and their endocrine disruption potentials: A mini-review.
Kwon B, Choi K. Kwon B, et al. Integr Environ Assess Manag. 2021 Sep;17(5):940-950. doi: 10.1002/ieam.4449. Epub 2021 Jun 11. Integr Environ Assess Manag. 2021. PMID: 33991024 Review.
In the present study, we chose other major organic UV filters, such as avobenzone (AVB), homosalate (HS), octisalate (OS), and octocrylene (OC), and reviewed information on their use, environmental occurrences, and endocrine disruption effects, availab …
In the present study, we chose other major organic UV filters, such as avobenzone (AVB), homosalate (HS), octisalate (O …
In vitro metabolism of sunscreen compounds by liquid chromatography/high-resolution tandem mass spectrometry.
Guesmi A, Ohlund L, Sleno L. Guesmi A, et al. Rapid Commun Mass Spectrom. 2020 Apr 30;34(8):e8679. doi: 10.1002/rcm.8679. Rapid Commun Mass Spectrom. 2020. PMID: 31782973
METHODS: Liquid chromatography coupled to high-resolution tandem mass spectrometry (LC/HRMS/MS) was employed to evaluate the oxidative metabolism and, specifically, the formation of reactive metabolites of six active ingredients commonly used in sunscreen formulations: oxybenzone …
METHODS: Liquid chromatography coupled to high-resolution tandem mass spectrometry (LC/HRMS/MS) was employed to evaluate the oxidative metab …
Influence of sunscreen formulation on the transfer of mineral and organic ultraviolet filters from skin to seawater in simulated ocean bathing tests.
Saxe JK, Mullins L, Jones R, Lewis A Jr, Sun F, Reynertson KA. Saxe JK, et al. Int J Cosmet Sci. 2023 Oct;45 Suppl 1:84-92. doi: 10.1111/ics.12901. Int J Cosmet Sci. 2023. PMID: 37625851
The rinsed mass of six UVFs - zinc oxide, titanium dioxide, avobenzone, homosalate, octisalate, and octocrylene - was determined analytically in synthetic seawater and in extractant rinsate from glassware for organic UVFs and compared among formulas. . …
The rinsed mass of six UVFs - zinc oxide, titanium dioxide, avobenzone, homosalate, octisalate, and octocrylene …
Retrospective Review of Dermal Safety Studies of Organic Sunscreens.
Wilson LT, Chu C, Wang SQ, Amponin R, Williams JD, Southall MD, Ejaz S. Wilson LT, et al. J Drugs Dermatol. 2025 Sep 1;24(9):897-903. doi: 10.36849/jdd.9191. J Drugs Dermatol. 2025. PMID: 40911743
OBJECTIVE: The aim of the retrospective study was to assess the dermal safety of chemical sunscreens containing the chemical filters avobenzone, octocrylene, homosalate, and octisalate. METHOD: A retrospective assessment was conducted of clinical resul …
OBJECTIVE: The aim of the retrospective study was to assess the dermal safety of chemical sunscreens containing the chemical filters avob …
18 results