Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1979 1
1980 1
1981 9
1982 2
1983 2
1984 2
1985 3
1986 4
1987 8
1988 21
1989 24
1990 22
1991 28
1992 31
1993 29
1994 23
1995 22
1996 25
1997 36
1998 30
1999 19
2000 10
2001 13
2002 16
2003 18
2004 10
2005 8
2006 9
2007 10
2008 15
2009 15
2010 10
2011 12
2012 16
2013 11
2014 16
2015 12
2016 14
2017 9
2018 11
2019 14
2020 7
2021 16
2022 9
2023 8
2024 10
2025 9

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

626 results

Results by year

Filters applied: . Clear all
Page 1
Second-generation antihistamines: a comparative review.
Slater JW, Zechnich AD, Haxby DG. Slater JW, et al. Drugs. 1999 Jan;57(1):31-47. doi: 10.2165/00003495-199957010-00004. Drugs. 1999. PMID: 9951950
This article evaluates second-generation antihistamines, including acrivastine, astemizole, azelastine, cetirizine, ebastine, fexofenadine, ketotifen, loratadine, mizolastine and terfenadine, for significant features that affect choice. ...
This article evaluates second-generation antihistamines, including acrivastine, astemizole, azelastine, cetirizine, ebastine, fexofen …
Antiviral Potential of Azelastine against Major Respiratory Viruses.
Fischhuber K, Bánki Z, Kimpel J, Kragl N, Rössler A, Bolze A, Muellauer B, Angerer J, Nagy G, Nagy E, Szijarto V. Fischhuber K, et al. Viruses. 2023 Nov 23;15(12):2300. doi: 10.3390/v15122300. Viruses. 2023. PMID: 38140540 Free PMC article.
We previously demonstrated that the antihistamine azelastine hydrochloride (azelastine-HCl) exhibited in vitro antiviral activity against SARS-CoV-2. ...Here, we evaluate the efficacy of azelastine-HCl against additional human coronaviruses, including the SAR …
We previously demonstrated that the antihistamine azelastine hydrochloride (azelastine-HCl) exhibited in vitro antiviral activ …
Azelastine inhibits viropexis of SARS-CoV-2 spike pseudovirus by binding to SARS-CoV-2 entry receptor ACE2.
Ge S, Lu J, Hou Y, Lv Y, Wang C, He H. Ge S, et al. Virology. 2021 Aug;560:110-115. doi: 10.1016/j.virol.2021.05.009. Epub 2021 May 25. Virology. 2021. PMID: 34052578 Free PMC article.
Here, we discovered antihistamine azelastine has an affinity to ACE2 by cell membrane chromatography (CMC); Then we determined the equilibrium dissociation constant (K(D)) of azelastine-ACE2 as (2.58 0.48) 10(-7) M by surface plasmon resonance (SPR). The results of …
Here, we discovered antihistamine azelastine has an affinity to ACE2 by cell membrane chromatography (CMC); Then we determined the eq …
Azelastine hydrochloride: a review of pharmacology, pharmacokinetics, clinical efficacy and tolerability.
Bernstein JA. Bernstein JA. Curr Med Res Opin. 2007 Oct;23(10):2441-52. doi: 10.1185/030079907X226302. Curr Med Res Opin. 2007. PMID: 17723160 Review.
Azelastine has demonstrated a wide range of pharmacologic effects on chemical mediators of inflammation including leukotrienes, kinins, and platelet activating factor in vitro and in vivo. ...Clinical studies demonstrated that azelastine nasal spray can improve symp …
Azelastine has demonstrated a wide range of pharmacologic effects on chemical mediators of inflammation including leukotrienes, kinin …
Azelastine nasal spray: a review of pharmacology and clinical efficacy in allergic and nonallergic rhinitis.
Lieberman PL, Settipane RA. Lieberman PL, et al. Allergy Asthma Proc. 2003 Mar-Apr;24(2):95-105. Allergy Asthma Proc. 2003. PMID: 12776442 Review.
Azelastine hydrochloride is a pharmacologically distinct H1-receptor antagonist with a broad spectrum of antiallergic and anti-inflammatory activity. ...This article reviews the pharmacologic profile and clinical efficacy and safety of azelastine nasal spray....
Azelastine hydrochloride is a pharmacologically distinct H1-receptor antagonist with a broad spectrum of antiallergic and anti-inflam …
Azelastine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential.
McTavish D, Sorkin EM. McTavish D, et al. Drugs. 1989 Nov;38(5):778-800. doi: 10.2165/00003495-198938050-00005. Drugs. 1989. PMID: 2574665 Review.
Azelastine is an antiallergic agent which demonstrates histamine H1-receptor antagonist activity and also inhibits histamine release from mast cells following antigen and non-antigen stimuli. ...Azelastine is also a potent antiasthmatic agent which produces signific …
Azelastine is an antiallergic agent which demonstrates histamine H1-receptor antagonist activity and also inhibits histamine release …
Anti-chlamydial effects of azelastine hydrochloride and the impact of the histamine H1 receptor on chlamydial development.
Kuratli J, Leonard CA, Schoborg R, Borel N. Kuratli J, et al. J Med Microbiol. 2023 May;72(5). doi: 10.1099/jmm.0.001691. J Med Microbiol. 2023. PMID: 37195751
These effects were strongest when azelastine was added shortly after or with the infection. Azelastine effects were not alleviated by increased concentrations of culture medium nutrients. ...Thus, it appears likely that off-target mechanisms of azelastine may …
These effects were strongest when azelastine was added shortly after or with the infection. Azelastine effects were not allevi …
Azelastine and olopatadine in the treatment of allergic rhinitis.
Kaliner MA. Kaliner MA. Ann Allergy Asthma Immunol. 2009 Nov;103(5):373-80. doi: 10.1016/S1081-1206(10)60355-9. Ann Allergy Asthma Immunol. 2009. PMID: 19927534 Review.
STUDY SELECTION: Clinical trials focusing on the efficacy, safety, and recommended uses of the currently approved nasal antihistamines in the United States: azelastine nasal spray, 0.1%, and olopatadine nasal spray, 0.6%. RESULTS: Azelastine nasal spray, 0.1%, and o …
STUDY SELECTION: Clinical trials focusing on the efficacy, safety, and recommended uses of the currently approved nasal antihistamines in th …
Intranasal azelastine. A review of its efficacy in the management of allergic rhinitis.
McNeely W, Wiseman LR. McNeely W, et al. Drugs. 1998 Jul;56(1):91-114. doi: 10.2165/00003495-199856010-00011. Drugs. 1998. PMID: 9664202 Review.
Azelastine, a phthalazinone compound, is a second generation histamine H1 receptor antagonist which has shown clinical efficacy in relieving the symptoms of allergic rhinitis when administered as either an oral or intranasal formulation. ...The relative efficacies of az …
Azelastine, a phthalazinone compound, is a second generation histamine H1 receptor antagonist which has shown clinical efficacy in re …
626 results