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Page 1
Azithromycin hydrates-implications of processing-induced phase transformations.
Sundaramurthi P, Suryanarayanan R. Sundaramurthi P, et al. J Pharm Sci. 2014 Oct;103(10):3095-106. doi: 10.1002/jps.24084. Epub 2014 Aug 19. J Pharm Sci. 2014. PMID: 25139082
According to label claims, in commercial solid dosage forms, azithromycin (AZI) exists either as a monohydrate (MH) or as a dihydrate (DH). Although these two forms are known to be relatively stable in the solid state, AZI sesquihydrate (SH) was observed in a drug product. …
According to label claims, in commercial solid dosage forms, azithromycin (AZI) exists either as a monohydrate (MH) or as a dihydrate …
Characterization of azithromycin hydrates.
Gandhi R, Pillai O, Thilagavathi R, Gopalakrishnan B, Kaul CL, Panchagnula R. Gandhi R, et al. Eur J Pharm Sci. 2002 Aug;16(3):175-84. doi: 10.1016/s0928-0987(02)00087-8. Eur J Pharm Sci. 2002. PMID: 12128172
Azithromycin (AZI) is a macrolide antibiotic with an expanded spectrum of activity that is commercially available as a dihydrate. This study was carried out to characterize hydrates of azithromycin. A commercial dihydrate sample was used to prepare monohydrate from
Azithromycin (AZI) is a macrolide antibiotic with an expanded spectrum of activity that is commercially available as a dihydrate. Thi
Ultrashort regimen of lansoprazole-amoxicillin-azithromycin for eradicating Helicobacter pylori.
Chahine C, Moukhachen O, Chedid M, Araj GF, Sharara AI. Chahine C, et al. Am J Health Syst Pharm. 2001 Oct 1;58(19):1819-23. doi: 10.1093/ajhp/58.19.1819. Am J Health Syst Pharm. 2001. PMID: 11596697 Clinical Trial.
In both groups, patients received lansoprazole 30 mg p.o. twice daily on day 1 and, on days 2 and 3, lansoprazole 30 mg p.o. twice daily, amoxicillin 1 g (of anhydrous amoxicillin) p.o. twice daily, and azithromycin 500 mg (of anhydrous azithromycin) p …
In both groups, patients received lansoprazole 30 mg p.o. twice daily on day 1 and, on days 2 and 3, lansoprazole 30 mg p.o. twice daily, am …
Atomic Force Microscopy to Identify Dehydration Temperatures for Small Volumes of Active Pharmaceutical Ingredients.
Atamanuk K, Thomas MC, Wadams RC, Linthicum W, Yu W, Huey BD. Atamanuk K, et al. Powder Technol. 2020 Jan 15;360:1271-1277. doi: 10.1016/j.powtec.2019.09.045. Epub 2019 Sep 16. Powder Technol. 2020. PMID: 32231400 Free PMC article.
Atomic Force Microscopy indentation mapping is implemented at controlled temperatures between 25-100 C, for nanoscale volumes of hydrated APIs exhibiting distinct dehydration behavior and anhydrous APIs as controls. For caffeine hydrate and azithromycin dihydrate, t …
Atomic Force Microscopy indentation mapping is implemented at controlled temperatures between 25-100 C, for nanoscale volumes of hydrated AP …
Application of NIR spectroscopy in polymorphic analysis: study of pseudo-polymorphs stability.
Blanco M, Valdés D, Llorente I, Bayod M. Blanco M, et al. J Pharm Sci. 2005 Jun;94(6):1336-42. doi: 10.1002/jps.20362. J Pharm Sci. 2005. PMID: 15858852
The accelerated transformation of three azithromycin pseudo-polymorphs (viz. the anhydrous, monohydrate (MH), and dihydrate (DH) forms) at a high temperature and moisture level was examined by near infrared spectroscopy (NIRS). ...The qualitative analysis of the NIR …
The accelerated transformation of three azithromycin pseudo-polymorphs (viz. the anhydrous, monohydrate (MH), and dihydrate (D …