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Page 1
Benazeprilat disposition and effect in dogs revisited with a pharmacokinetic/pharmacodynamic modeling approach.
Toutain PL, Lefebvre HP, King JN. Toutain PL, et al. J Pharmacol Exp Ther. 2000 Mar;292(3):1087-93. J Pharmacol Exp Ther. 2000. PMID: 10688627
The activity of benazeprilat was assessed by measuring plasma ACE inhibition with an ex vivo assay. Benazeprilat data were fitted to equations corresponding to a monocompartmental model with a volume equal to the extracellular space ( approximately 0.2 l/kg) in whic …
The activity of benazeprilat was assessed by measuring plasma ACE inhibition with an ex vivo assay. Benazeprilat data were fit …
Pharmacokinetic/pharmacodynamic modeling of benazepril and benazeprilat after administration of intravenous and oral doses of benazepril in healthy horses.
Serrano-Rodríguez JM, Gómez-Díez M, Esgueva M, Castejón-Riber C, Mena-Bravo A, Priego-Capote F, Ayala N, Caballero JMS, Muñoz A. Serrano-Rodríguez JM, et al. Res Vet Sci. 2017 Oct;114:117-122. doi: 10.1016/j.rvsc.2017.03.016. Epub 2017 Mar 28. Res Vet Sci. 2017. PMID: 28371693 Clinical Trial.
Pharmacokinetic and pharmacodynamic (PK/PD) properties of the angiotensin-converting enzyme inhibitor (ACEI) benazeprilat have not been evaluated in horses. This study was designed to establish PK profiles for benazepril and benazeprilat after intravenous (IV …
Pharmacokinetic and pharmacodynamic (PK/PD) properties of the angiotensin-converting enzyme inhibitor (ACEI) benazeprilat have …
The pharmacokinetics of benazepril relative to other ACE inhibitors.
Gengo FM, Brady E. Gengo FM, et al. Clin Cardiol. 1991 Aug;14(8 Suppl 4):IV44-50; discussion IV51-5. doi: 10.1002/clc.4960141807. Clin Cardiol. 1991. PMID: 1893642 Free article. Review.
Following oral administration, benazepril is absorbed and transformed into benazeprilat in the liver. Coadministration of benazepril with food delays absorption slightly but does not affect the ultimate bioavailability of benazeprilat. Severe hepatic impairment slow …
Following oral administration, benazepril is absorbed and transformed into benazeprilat in the liver. Coadministration of benazepril …
Pharmacokinetic/pharmacodynamic modelling of the disposition and effect of benazepril and benazeprilat in cats.
King JN, Maurer M, Toutain PL. King JN, et al. J Vet Pharmacol Ther. 2003 Jun;26(3):213-24. doi: 10.1046/j.1365-2885.2003.00468.x. J Vet Pharmacol Ther. 2003. PMID: 12755906
Within this space, benazeprilat was bound nonlinearly to ACE, which was mainly tissular (89.4%) rather than circulating (10.6%). ...Nevertheless, inhibition of ACE was long-lasting (t1/2 16-23 h) due to high affinity binding of benazeprilat to ACE (Kd approximately …
Within this space, benazeprilat was bound nonlinearly to ACE, which was mainly tissular (89.4%) rather than circulating (10.6%). ...N …
Pharmacokinetics of the angiotensin-converting-enzyme inhibitor, benazepril, and its active metabolite, benazeprilat, in dog.
King JN, Maurer M, Morrison CA, Mauron C, Kaiser G. King JN, et al. Xenobiotica. 1997 Aug;27(8):819-29. doi: 10.1080/004982597240181. Xenobiotica. 1997. PMID: 9293618
The mean residence time for benazeprilat was 15.2 h after the single dose and 17.4 h after the 14th dose. 3. Repeated administration of benazepril produced moderate bioaccumulation of benazeprilat; the ratio of AUC[0-->24 h]'s after the 14th dose as compared with …
The mean residence time for benazeprilat was 15.2 h after the single dose and 17.4 h after the 14th dose. 3. Repeated administration …
Hemodynamic effects of amlodipine and benazeprilat in spontaneously hypertensive rats.
Bazil MK, Webb RL. Bazil MK, et al. J Cardiovasc Pharmacol. 1993 Mar;21(3):405-11. doi: 10.1097/00005344-199303000-00009. J Cardiovasc Pharmacol. 1993. PMID: 7681501
Administration of benazeprilat (0.1-10 mg/kg i.v.) decreased arterial MAP, and benazeprilat (10 mg/kg) effectively blocked the effects of exogenously administered angiotensin I (AI). ...Simultaneous administration of amlodipine and benazeprilat produced reduc …
Administration of benazeprilat (0.1-10 mg/kg i.v.) decreased arterial MAP, and benazeprilat (10 mg/kg) effectively blocked the …
Amlodipine and benazeprilat differently affect the responses to endothelin-1 and bradykinin in porcine ciliary arteries: effects of a low and high dose combination.
Lang MG, Zhu P, Meyer P, Noll G, Haefliger IO, Flammer J, Lüscher TF. Lang MG, et al. Curr Eye Res. 1997 Mar;16(3):208-13. doi: 10.1076/ceyr.16.3.208.15401. Curr Eye Res. 1997. PMID: 9088736
Therefore, the effects of the calcium antagonist amlodipine and the angiotensin converting enzyme (ACE) inhibitor benazeprilat at low and high dose combination on contractions to endothelin-1 and endothelium-dependent relaxations to bradykinin were examined in porcine cili …
Therefore, the effects of the calcium antagonist amlodipine and the angiotensin converting enzyme (ACE) inhibitor benazeprilat at low …
Simultaneous determination of lercanidipine, benazepril and benazeprilat in plasma by LC-MS/MS and its application to a toxicokinetics study.
Chen K, Zhang J, Liu S, Zhang D, Teng Y, Wei C, Wang B, Liu X, Yuan G, Zhang R, Zhao W, Guo R. Chen K, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Jun 15;899:1-7. doi: 10.1016/j.jchromb.2012.04.014. Epub 2012 May 8. J Chromatogr B Analyt Technol Biomed Life Sci. 2012. PMID: 22622066
We aim to develop a rapid, simple, sensitive and specific LC-MS/MS method for the simultaneous quantification of lercanidipine, benazepril and benazeprilat in plasma. It is performed on the Agilent 6410 LC-MS/MS under the multiple-reaction monitoring (MRM) mode with electr …
We aim to develop a rapid, simple, sensitive and specific LC-MS/MS method for the simultaneous quantification of lercanidipine, benazepril a …
Prolonged angiotensin II antagonism in spontaneously hypertensive rats. Hemodynamic and biochemical consequences.
Bunkenburg B, Schnell C, Baum HP, Cumin F, Wood JM. Bunkenburg B, et al. Hypertension. 1991 Sep;18(3):278-88. doi: 10.1161/01.hyp.18.3.278. Hypertension. 1991. PMID: 1889842
DuP 753 (10 or 30 mg/kg/day) lowered mean arterial pressure to the same extent as benazeprilat (3 or 10 mg/kg/day) during a 48-hour period. The antihypertensive effect was sustained when the treatment was extended to 7 days (DuP 753, 10 mg/kg/day; benazeprilat, 3 mg …
DuP 753 (10 or 30 mg/kg/day) lowered mean arterial pressure to the same extent as benazeprilat (3 or 10 mg/kg/day) during a 48-hour p …
Simultaneous determination of benazepril hydrochloride and benazeprilat in plasma by high-performance liquid chromatography/electrospray-mass spectrometry.
Xiao W, Chen B, Yao S, Cheng Z. Xiao W, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Jan 25;814(2):303-8. doi: 10.1016/j.jchromb.2004.10.047. J Chromatogr B Analyt Technol Biomed Life Sci. 2005. PMID: 15639452
An analytical method for simultaneous determination of benazepril and its active metabolite, benazeprilat, in human plasma by high-performance liquid chromatography/electrospray-mass spectrometry was developed and validated. ...The correlation coefficients of the calibrati …
An analytical method for simultaneous determination of benazepril and its active metabolite, benazeprilat, in human plasma by high-pe …
87 results