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Page 1
Benazeprilat disposition and effect in dogs revisited with a pharmacokinetic/pharmacodynamic modeling approach.
Toutain PL, Lefebvre HP, King JN. Toutain PL, et al. J Pharmacol Exp Ther. 2000 Mar;292(3):1087-93. J Pharmacol Exp Ther. 2000. PMID: 10688627
The activity of benazeprilat was assessed by measuring plasma ACE inhibition with an ex vivo assay. Benazeprilat data were fitted to equations corresponding to a monocompartmental model with a volume equal to the extracellular space ( approximately 0.2 l/kg) in whic …
The activity of benazeprilat was assessed by measuring plasma ACE inhibition with an ex vivo assay. Benazeprilat data were fit …
Pharmacokinetic/pharmacodynamic modelling of the disposition and effect of benazepril and benazeprilat in cats.
King JN, Maurer M, Toutain PL. King JN, et al. J Vet Pharmacol Ther. 2003 Jun;26(3):213-24. doi: 10.1046/j.1365-2885.2003.00468.x. J Vet Pharmacol Ther. 2003. PMID: 12755906
Within this space, benazeprilat was bound nonlinearly to ACE, which was mainly tissular (89.4%) rather than circulating (10.6%). ...Nevertheless, inhibition of ACE was long-lasting (t1/2 16-23 h) due to high affinity binding of benazeprilat to ACE (Kd approximately …
Within this space, benazeprilat was bound nonlinearly to ACE, which was mainly tissular (89.4%) rather than circulating (10.6%). ...N …
Pharmacokinetic/pharmacodynamic modeling of benazepril and benazeprilat after administration of intravenous and oral doses of benazepril in healthy horses.
Serrano-Rodríguez JM, Gómez-Díez M, Esgueva M, Castejón-Riber C, Mena-Bravo A, Priego-Capote F, Ayala N, Caballero JMS, Muñoz A. Serrano-Rodríguez JM, et al. Res Vet Sci. 2017 Oct;114:117-122. doi: 10.1016/j.rvsc.2017.03.016. Epub 2017 Mar 28. Res Vet Sci. 2017. PMID: 28371693 Clinical Trial.
Pharmacokinetic and pharmacodynamic (PK/PD) properties of the angiotensin-converting enzyme inhibitor (ACEI) benazeprilat have not been evaluated in horses. This study was designed to establish PK profiles for benazepril and benazeprilat after intravenous (IV) and o …
Pharmacokinetic and pharmacodynamic (PK/PD) properties of the angiotensin-converting enzyme inhibitor (ACEI) benazeprilat have not be …
Pharmacokinetics of the angiotensin-converting-enzyme inhibitor, benazepril, and its active metabolite, benazeprilat, in dog.
King JN, Maurer M, Morrison CA, Mauron C, Kaiser G. King JN, et al. Xenobiotica. 1997 Aug;27(8):819-29. doi: 10.1080/004982597240181. Xenobiotica. 1997. PMID: 9293618
The mean residence time for benazeprilat was 15.2 h after the single dose and 17.4 h after the 14th dose. 3. Repeated administration of benazepril produced moderate bioaccumulation of benazeprilat; the ratio of AUC[0-->24 h]'s after the 14th dose as compared with …
The mean residence time for benazeprilat was 15.2 h after the single dose and 17.4 h after the 14th dose. 3. Repeated administration …
Hemodynamic effects of amlodipine and benazeprilat in spontaneously hypertensive rats.
Bazil MK, Webb RL. Bazil MK, et al. J Cardiovasc Pharmacol. 1993 Mar;21(3):405-11. doi: 10.1097/00005344-199303000-00009. J Cardiovasc Pharmacol. 1993. PMID: 7681501
Administration of benazeprilat (0.1-10 mg/kg i.v.) decreased arterial MAP, and benazeprilat (10 mg/kg) effectively blocked the effects of exogenously administered angiotensin I (AI). ...Simultaneous administration of amlodipine and benazeprilat produced reduc …
Administration of benazeprilat (0.1-10 mg/kg i.v.) decreased arterial MAP, and benazeprilat (10 mg/kg) effectively blocked the …
Amlodipine and benazeprilat differently affect the responses to endothelin-1 and bradykinin in porcine ciliary arteries: effects of a low and high dose combination.
Lang MG, Zhu P, Meyer P, Noll G, Haefliger IO, Flammer J, Lüscher TF. Lang MG, et al. Curr Eye Res. 1997 Mar;16(3):208-13. doi: 10.1076/ceyr.16.3.208.15401. Curr Eye Res. 1997. PMID: 9088736
Therefore, the effects of the calcium antagonist amlodipine and the angiotensin converting enzyme (ACE) inhibitor benazeprilat at low and high dose combination on contractions to endothelin-1 and endothelium-dependent relaxations to bradykinin were examined in porcine cili …
Therefore, the effects of the calcium antagonist amlodipine and the angiotensin converting enzyme (ACE) inhibitor benazeprilat at low …
Simultaneous and rapid quantitation of benazepril and benazeprilat in human plasma by high performance liquid chromatography with ultraviolet detection.
Wang XD, Chan E, Chen X, Liao XX, Tang C, Zhou ZW, Huang M, Zhou SF. Wang XD, et al. J Pharm Biomed Anal. 2007 May 9;44(1):224-30. doi: 10.1016/j.jpba.2007.01.009. Epub 2007 Jan 17. J Pharm Biomed Anal. 2007. PMID: 17289327
A sensitive and accurate high-performance liquid chromatography (HPLC) method with ultraviolet (UV) detector was developed and validated for simultaneous determination of benazepril (BZL) and its active metabolite, benazeprilat (BZT), in human plasma. The plasma sample, af …
A sensitive and accurate high-performance liquid chromatography (HPLC) method with ultraviolet (UV) detector was developed and validated for …
[Simultaneous determination of amlodipine, benazepril and benazeprilat in human plasma by LC-HESI/MS/MS method].
Pan HL, Lin LS, Ding JF, Chen XY, Zhong DF. Pan HL, et al. Yao Xue Xue Bao. 2014 Jan;49(1):95-100. Yao Xue Xue Bao. 2014. PMID: 24783513 Chinese.
The study aims to develop a rapid, sensitive and specified method of liquid chromatography with heated electrospray ionization tandem mass spectrometry (LC-HESI/MS/MS) for simultaneous determination of amlodipine, benazepril and benazeprilat in human plasma using amlodipin …
The study aims to develop a rapid, sensitive and specified method of liquid chromatography with heated electrospray ionization tandem mass s …
Plasma concentrations of an angiotensin-converting enzyme inhibitor, benazepril, and its active metabolite, benazeprilat, after repeated administrations of benazepril in dogs with experimental kidney impairment.
Kitagawa H, Eguchi T, Kitoh K, Ohba Y, Kondo M, Nakano M, Sasaki Y. Kitagawa H, et al. J Vet Med Sci. 2000 Feb;62(2):179-85. doi: 10.1292/jvms.62.179. J Vet Med Sci. 2000. PMID: 10720188 Free article.
However, these parameters did not change significantly during the 1/4th kidney period both in the 0.5 mg/kg and 10 mg/kg groups. In the 0.5 mg/kg group, plasma benazeprilat concentrations increased to approximately 20 ng/ml to 340 ng/ml 2 hr after each administration, and …
However, these parameters did not change significantly during the 1/4th kidney period both in the 0.5 mg/kg and 10 mg/kg groups. In the 0.5 …
Protective effects of valsartan and benazeprilat in salt-loaded stroke-prone spontaneously hypertensive rats.
Webb RL, Barclay BW, Navarrete AE, Wosu NJ, Sahota P. Webb RL, et al. Clin Exp Hypertens. 1998 Oct;20(7):775-93. doi: 10.3109/10641969809052119. Clin Exp Hypertens. 1998. PMID: 9764721
These experiments examined the effectiveness of chronic blockade of the renin angiotensin system with either valsartan or benazeprilat on survival, blood pressure and end-organ damage in salt-loaded stroke-prone SHR. Valsartan or benazeprilat given continuously by s …
These experiments examined the effectiveness of chronic blockade of the renin angiotensin system with either valsartan or benazeprilat …
41 results