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105 results

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Page 1
The pharmacokinetics of benazepril relative to other ACE inhibitors.
Gengo FM, Brady E. Gengo FM, et al. Clin Cardiol. 1991 Aug;14(8 Suppl 4):IV44-50; discussion IV51-5. doi: 10.1002/clc.4960141807. Clin Cardiol. 1991. PMID: 1893642 Free article. Review.
Following oral administration, benazepril is absorbed and transformed into benazeprilat in the liver. Coadministration of benazepril with food delays absorption slightly but does not affect the ultimate bioavailability of benazeprilat. Severe hepatic impairment slow …
Following oral administration, benazepril is absorbed and transformed into benazeprilat in the liver. Coadministration of benazepril …
Benazeprilat disposition and effect in dogs revisited with a pharmacokinetic/pharmacodynamic modeling approach.
Toutain PL, Lefebvre HP, King JN. Toutain PL, et al. J Pharmacol Exp Ther. 2000 Mar;292(3):1087-93. J Pharmacol Exp Ther. 2000. PMID: 10688627
The activity of benazeprilat was assessed by measuring plasma ACE inhibition with an ex vivo assay. Benazeprilat data were fitted to equations corresponding to a monocompartmental model with a volume equal to the extracellular space ( approximately 0.2 l/kg) in whic …
The activity of benazeprilat was assessed by measuring plasma ACE inhibition with an ex vivo assay. Benazeprilat data were fit …
Pharmacokinetic/pharmacodynamic modeling of benazepril and benazeprilat after administration of intravenous and oral doses of benazepril in healthy horses.
Serrano-Rodríguez JM, Gómez-Díez M, Esgueva M, Castejón-Riber C, Mena-Bravo A, Priego-Capote F, Ayala N, Caballero JMS, Muñoz A. Serrano-Rodríguez JM, et al. Res Vet Sci. 2017 Oct;114:117-122. doi: 10.1016/j.rvsc.2017.03.016. Epub 2017 Mar 28. Res Vet Sci. 2017. PMID: 28371693 Clinical Trial.
Pharmacokinetic and pharmacodynamic (PK/PD) properties of the angiotensin-converting enzyme inhibitor (ACEI) benazeprilat have not been evaluated in horses. This study was designed to establish PK profiles for benazepril and benazeprilat after intravenous (IV) and o …
Pharmacokinetic and pharmacodynamic (PK/PD) properties of the angiotensin-converting enzyme inhibitor (ACEI) benazeprilat have not be …
Hemodynamic effects of amlodipine and benazeprilat in spontaneously hypertensive rats.
Bazil MK, Webb RL. Bazil MK, et al. J Cardiovasc Pharmacol. 1993 Mar;21(3):405-11. doi: 10.1097/00005344-199303000-00009. J Cardiovasc Pharmacol. 1993. PMID: 7681501
Administration of benazeprilat (0.1-10 mg/kg i.v.) decreased arterial MAP, and benazeprilat (10 mg/kg) effectively blocked the effects of exogenously administered angiotensin I (AI). ...Simultaneous administration of amlodipine and benazeprilat produced reduc …
Administration of benazeprilat (0.1-10 mg/kg i.v.) decreased arterial MAP, and benazeprilat (10 mg/kg) effectively blocked the …
Pharmacokinetics of the angiotensin-converting-enzyme inhibitor, benazepril, and its active metabolite, benazeprilat, in dog.
King JN, Maurer M, Morrison CA, Mauron C, Kaiser G. King JN, et al. Xenobiotica. 1997 Aug;27(8):819-29. doi: 10.1080/004982597240181. Xenobiotica. 1997. PMID: 9293618
The mean residence time for benazeprilat was 15.2 h after the single dose and 17.4 h after the 14th dose. 3. Repeated administration of benazepril produced moderate bioaccumulation of benazeprilat; the ratio of AUC[0-->24 h]'s after the 14th dose as compared with …
The mean residence time for benazeprilat was 15.2 h after the single dose and 17.4 h after the 14th dose. 3. Repeated administration …
Clinical pharmacokinetics of the newer ACE inhibitors. A review.
Kelly JG, O'Malley K. Kelly JG, et al. Clin Pharmacokinet. 1990 Sep;19(3):177-96. doi: 10.2165/00003088-199019030-00003. Clin Pharmacokinet. 1990. PMID: 2203579 Review.
However, there is considerable variation within and between drugs, with benazepril and benazeprilat reaching peak concentrations early and enalapril and enalaprilat typical of later times to peak. ...Half-lives of accumulation are of the order of 12 hours; protein binding …
However, there is considerable variation within and between drugs, with benazepril and benazeprilat reaching peak concentrations earl …
Hemodynamic effects of benazeprilat in the anesthetized dog with acute left ventricular failure.
Nakazawa M, Sawanobori T, Iwasaki K, Imai S. Nakazawa M, et al. Jpn J Pharmacol. 1991 Jul;56(3):369-75. doi: 10.1254/jjp.56.369. Jpn J Pharmacol. 1991. PMID: 1895581 Free article.
The total peripheral resistance was reduced with benazeprilat. The oxygen consumption and the coronary blood flow were reduced with benazeprilat because of a decrease in wall tension and afterload. These results suggest that benazeprilat (benazepril) has bene …
The total peripheral resistance was reduced with benazeprilat. The oxygen consumption and the coronary blood flow were reduced with …
Effect of High-Fat Food on the Pharmacokinetics and Safety of Amlodipine/Benazepril in Healthy Chinese Participants.
Ding C, Song H, Qiu B, Sun X, Guo C, Bai W, Wu H, Dong Z. Ding C, et al. Clin Pharmacol Drug Dev. 2026 Jan;15(1):e70022. doi: 10.1002/cpdd.70022. Clin Pharmacol Drug Dev. 2026. PMID: 41549805 Clinical Trial.
The plasma concentrations of amlodipine, benazepril, and benazeprilat were determined by a validated liquid chromatography-tandem mass spectrometry method. ...The high-fat food decreased C(max) of benazepril by 64.1% and C(max) of benazeprilat by 30.8%, and increase …
The plasma concentrations of amlodipine, benazepril, and benazeprilat were determined by a validated liquid chromatography-tandem mas …
Pharmacokinetics and pharmacodynamics of the ace inhibitor benazepril hydrochloride in the elderly.
Kaiser G, Ackermann R, Dieterle W, Durnin CJ, McEwen J, Ghose K, Richens A, Holmes IB. Kaiser G, et al. Eur J Clin Pharmacol. 1990;38(4):379-85. doi: 10.1007/BF00315579. Eur J Clin Pharmacol. 1990. PMID: 2344861
The elimination half-life of benazeprilat during the first 24 h after dosing in the elderly was increased by about 20% to 3.2 h. The renal plasma clearance of benazeprilat (18.1 ml.min-1) was about 20% smaller than in the young subjects. An average of 18.5% of the d …
The elimination half-life of benazeprilat during the first 24 h after dosing in the elderly was increased by about 20% to 3.2 h. The …
105 results