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Pharmacokinetic/pharmacodynamic modeling of benazepril and benazeprilat after administration of intravenous and oral doses of benazepril in healthy horses.
Serrano-Rodríguez JM, Gómez-Díez M, Esgueva M, Castejón-Riber C, Mena-Bravo A, Priego-Capote F, Ayala N, Caballero JMS, Muñoz A. Serrano-Rodríguez JM, et al. Res Vet Sci. 2017 Oct;114:117-122. doi: 10.1016/j.rvsc.2017.03.016. Epub 2017 Mar 28. Res Vet Sci. 2017. PMID: 28371693 Clinical Trial.
Pharmacokinetic and pharmacodynamic (PK/PD) properties of the angiotensin-converting enzyme inhibitor (ACEI) benazeprilat have not been evaluated in horses. This study was designed to establish PK profiles for benazepril and benazeprilat after intravenous (IV) and o …
Pharmacokinetic and pharmacodynamic (PK/PD) properties of the angiotensin-converting enzyme inhibitor (ACEI) benazeprilat have not be …
Effect of High-Fat Food on the Pharmacokinetics and Safety of Amlodipine/Benazepril in Healthy Chinese Participants.
Ding C, Song H, Qiu B, Sun X, Guo C, Bai W, Wu H, Dong Z. Ding C, et al. Clin Pharmacol Drug Dev. 2026 Jan;15(1):e70022. doi: 10.1002/cpdd.70022. Clin Pharmacol Drug Dev. 2026. PMID: 41549805 Clinical Trial.
The plasma concentrations of amlodipine, benazepril, and benazeprilat were determined by a validated liquid chromatography-tandem mass spectrometry method. ...The high-fat food decreased C(max) of benazepril by 64.1% and C(max) of benazeprilat by 30.8%, and increase …
The plasma concentrations of amlodipine, benazepril, and benazeprilat were determined by a validated liquid chromatography-tandem mas …
An angiotensin converting enzyme inhibitor, benazepril can be transformed to an active metabolite, benazeprilat, by the liver of dogs with ascitic pulmonary heartworm disease.
Kitagawa H, Ohba Y, Kuwahara Y, Ohne R, Kondo M, Nakano M, Sasaki Y, Kitoh K. Kitagawa H, et al. J Vet Med Sci. 2003 Jun;65(6):701-6. doi: 10.1292/jvms.65.701. J Vet Med Sci. 2003. PMID: 12867730 Clinical Trial.
In 7 dogs with ascitic pulmonary heartworm disease, plasma benazeprilat concentrations tended to be higher than in 7 control dogs both on the 1st and 7th administration days. ...In dogs with ascitic heartworm disease, benazepril was readily transformed to benazeprilat …
In 7 dogs with ascitic pulmonary heartworm disease, plasma benazeprilat concentrations tended to be higher than in 7 control dogs bot …
Determinants of angiotensin II generation during converting enzyme inhibition.
Juillerat L, Nussberger J, Ménard J, Mooser V, Christen Y, Waeber B, Graf P, Brunner HR. Juillerat L, et al. Hypertension. 1990 Nov;16(5):564-72. doi: 10.1161/01.hyp.16.5.564. Hypertension. 1990. PMID: 2172161 Clinical Trial.
A close linear relation was found between plasma angiotensin II and the angiotensin I/drug level ratio (r = 0.91 for benazeprilat and r = 0.88 for enalaprilat, p less than 0.001). Thus, plasma angiotensin II truly reflects the resetting of the renin-angiotensin system at a …
A close linear relation was found between plasma angiotensin II and the angiotensin I/drug level ratio (r = 0.91 for benazeprilat and …
Bioequivalence Study of Single-Pill Capsule Formulation of Amlodipine Plus Benazepril in Healthy Chinese Subjects Under Fasting and Fed Conditions.
Song H, Qiu B, Sun X, Guo C, Hu Y, Dong Z, Liu Y, Bai W. Song H, et al. Drug Des Devel Ther. 2025 Mar 13;19:1853-1868. doi: 10.2147/DDDT.S498337. eCollection 2025. Drug Des Devel Ther. 2025. PMID: 40098905 Free PMC article. Clinical Trial.
Blood samples were taken serially for up to 168 hours post-administration during each period, and the plasma levels of amlodipine, benazepril, and benazeprilat were measured using high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method. ...The 9 …
Blood samples were taken serially for up to 168 hours post-administration during each period, and the plasma levels of amlodipine, benazepri …
Pharmacokinetic interaction study between benazepril and amlodipine in healthy subjects.
Sun JX, Cipriano A, Chan K, John VA. Sun JX, et al. Eur J Clin Pharmacol. 1994;47(3):285-9. doi: 10.1007/BF02570510. Eur J Clin Pharmacol. 1994. PMID: 7867683 Clinical Trial.
Serial blood samples were collected following each administration for the determination of benazepril and its active metabolite benazeprilat and amlodipine. The mean values of AUC (0-4 h), Cmax and Tmax for benazepril given as combination versus given alone were 161 vs 140 …
Serial blood samples were collected following each administration for the determination of benazepril and its active metabolite benazepri …
Effect of renal insufficiency on the pharmacokinetics and pharmacodynamics of benazepril in cats.
King JN, Strehlau G, Wernsing J, Brown SA. King JN, et al. J Vet Pharmacol Ther. 2002 Oct;25(5):371-8. doi: 10.1046/j.1365-2885.2002.00427.x. J Vet Pharmacol Ther. 2002. PMID: 12423228 Clinical Trial.
The active metabolite of benazepril, benazeprilat, is eliminated principally ( approximately 85%) via biliary excretion in cats. ...There were no significant differences in SBP, DBP, MBP, benazeprilat or ACE values according to the degree of renal insufficiency in c …
The active metabolite of benazepril, benazeprilat, is eliminated principally ( approximately 85%) via biliary excretion in cats. ...T …
The effects of age on the pharmacokinetics and pharmacodynamics of single oral doses of benazepril and enalapril.
Macdonald NJ, Sioufi A, Howie CA, Wade JR, Elliott HL. Macdonald NJ, et al. Br J Clin Pharmacol. 1993 Sep;36(3):205-9. doi: 10.1111/j.1365-2125.1993.tb04218.x. Br J Clin Pharmacol. 1993. PMID: 9114905 Free PMC article. Clinical Trial.
The hypotensive effect was similar after both drugs but the absolute reductions were greater in the elderly who had higher initial levels of blood pressure. 3. The AUCs for both benazeprilat and enalaprilat were higher in the elderly but by a significantly greater amount f …
The hypotensive effect was similar after both drugs but the absolute reductions were greater in the elderly who had higher initial levels of …
Site-differential gastrointestinal absorption of benazepril hydrochloride in healthy volunteers.
Chan KK, Buch A, Glazer RD, John VA, Barr WH. Chan KK, et al. Pharm Res. 1994 Mar;11(3):432-7. doi: 10.1023/a:1018925407109. Pharm Res. 1994. PMID: 8008712 Clinical Trial.
Serial plasma and urine samples were collected for up to 4 days after dosing. BZPH and its active metabolite benazeprilat (BZPL) were determined using a gas chromatography/mass spectrometry method. BZPH was absorbed rapidly into the bloodstream (Tmax = 0.5 hr after ORAL). …
Serial plasma and urine samples were collected for up to 4 days after dosing. BZPH and its active metabolite benazeprilat (BZPL) were …
Bioequivalence of a new liquid formulation of benazepril compared with the reference tablet product.
Kelers K, Devi JL, Anderson GA, Zahra P, Vine JH, Whittem T. Kelers K, et al. Aust Vet J. 2013 Aug;91(8):312-9. doi: 10.1111/avj.12080. Aust Vet J. 2013. PMID: 23889096 Clinical Trial.
Blood samples taken prior to treatment and serially after treatment were analysed for plasma concentrations of benazepril and benazeprilat and the activity and concentration of angiotensin-converting enzyme (ACE). The calculated percentage inhibition of ACE was defined as …
Blood samples taken prior to treatment and serially after treatment were analysed for plasma concentrations of benazepril and benazeprila …
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