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Benzonatate as a local anesthetic.
McGuire A, Ostertag-Hill CA, Aizik G, Li Y, Kohane DS. McGuire A, et al. PLoS One. 2023 Apr 12;18(4):e0284401. doi: 10.1371/journal.pone.0284401. eCollection 2023. PLoS One. 2023. PMID: 37043508 Free PMC article.
Based on structural similarities to known local anesthetics and recent findings of benzonatate exerting local anesthetic-like effects on voltage-gated sodium channels in vitro, we hypothesized that benzonatate will act as a local anesthetic to yield periphera …
Based on structural similarities to known local anesthetics and recent findings of benzonatate exerting local anesthetic-like effe …
Benzonatate Exposure Trends and Adverse Events.
Kim I, Goulding M, Tian F, Karami S, Pham T, Cheng C, Biehl A, Muñoz M. Kim I, et al. Pediatrics. 2022 Dec 1;150(6):e2022057779. doi: 10.1542/peds.2022-057779. Pediatrics. 2022. PMID: 36377394 Free PMC article.
BACKGROUND AND OBJECTIVES: Adverse events (AE), including death, occur in children with benzonatate use. This study aims to understand recent trends in benzonatate exposure and clinical consequences in pediatric patients. ...The proportion of cases wit …
BACKGROUND AND OBJECTIVES: Adverse events (AE), including death, occur in children with benzonatate use. This study aim …
Drugs for cough.
[No authors listed] [No authors listed] Med Lett Drugs Ther. 2018 Dec 17;60(1562):206-208. Med Lett Drugs Ther. 2018. PMID: 30625123 Review. No abstract available.
A description of the clinical course of severe benzonatate poisonings reported in the literature and to NPDS: A systematic review supplemented with NPDS cases.
Minhaj FS, Leonard JB. Minhaj FS, et al. Hum Exp Toxicol. 2021 Dec;40(12_suppl):S39-S48. doi: 10.1177/09603271211030560. Epub 2021 Jul 5. Hum Exp Toxicol. 2021. PMID: 34219543
BACKGROUND: Benzonatate is a commonly prescribed medication that can be lethal in acute overdose of a small number of capsules. OBJECTIVE: This was a systematic review to describe the course of severe poisoning and deaths from benzonatate supplemented with the Natio …
BACKGROUND: Benzonatate is a commonly prescribed medication that can be lethal in acute overdose of a small number of capsules. OBJEC …
In brief: benzonatate warning.
[No authors listed] [No authors listed] Med Lett Drugs Ther. 2011 Feb 7;53(1357):9. Med Lett Drugs Ther. 2011. PMID: 21304443 Review. No abstract available.
Benzonatate Toxicity: Nothing to Cough At.
Bishop-Freeman SC, Shonsey EM, Friederich LW, Beuhler MC, Winecker RE. Bishop-Freeman SC, et al. J Anal Toxicol. 2017 Jun 1;41(5):461-463. doi: 10.1093/jat/bkx021. J Anal Toxicol. 2017. PMID: 28334901 No abstract available.
The Antitussive Benzonatate Is Not Tumorigenic in Rodent Carcinogenicity Studies.
Teo S, Paranjpe M, Mckeon M, Mann P, Lee S, LaRock R, Brown T. Teo S, et al. Toxicol Pathol. 2018 Aug;46(6):683-692. doi: 10.1177/0192623318789130. Epub 2018 Jul 22. Toxicol Pathol. 2018. PMID: 30033829
Benzonatate is a peripheral oral antitussive that dampens the activity of cough stretch receptors. ...Retinal atrophy was observed in male rats at 30 mg/kg/day, but the incidence was within historical control data range and not related to benzonatate. In conclusion, …
Benzonatate is a peripheral oral antitussive that dampens the activity of cough stretch receptors. ...Retinal atrophy was observed in …
Benzonatate toxicity in a teenager resulting in coma, seizures, and severe metabolic acidosis.
Thimann DA, Huang CJ, Goto CS, Feng SY. Thimann DA, et al. J Pediatr Pharmacol Ther. 2012 Jul;17(3):270-3. doi: 10.5863/1551-6776-17.3.270. J Pediatr Pharmacol Ther. 2012. PMID: 23258970 Free PMC article.
Benzonatate is an antitussive medication with sodium channel-blocking properties and local anesthetic effects on the respiratory stretch receptors due to a tetracaine-like metabolite. ...The FDA recently issued a Drug Safety Communication warning that accidental …
Benzonatate is an antitussive medication with sodium channel-blocking properties and local anesthetic effects on the respirato …
Analysis of benzonatate overdoses among adults and children from 1969-2010 by the United States Food and Drug Administration.
McLawhorn MW, Goulding MR, Gill RK, Michele TM. McLawhorn MW, et al. Pharmacotherapy. 2013 Jan;33(1):38-43. doi: 10.1002/phar.1153. Pharmacotherapy. 2013. PMID: 23307543
PATIENTS: Any patient who reported an adverse event with benzonatate captured in the AERS or NEISS-CADES database or received a prescription for benzonatate according to the IMS commercial data vendor. MEASUREMENTS AND MAIN RESULTS: Postmarketing adverse …
PATIENTS: Any patient who reported an adverse event with benzonatate captured in the AERS or NEISS-CADES database or received …
Genotoxicity assessment of the novel antitussive agent Benzonatate and its major metabolite.
Teo S, Madraymootoo W, Dakoulas E, Kulkarni R, McKeon M. Teo S, et al. Mutat Res Genet Toxicol Environ Mutagen. 2018 May-Jun;829-830:19-25. doi: 10.1016/j.mrgentox.2018.03.007. Epub 2018 Mar 21. Mutat Res Genet Toxicol Environ Mutagen. 2018. PMID: 29704989
The nonclinical and clinical efficacy of Benzonatate has been demonstrated over the last 60 years, but its safety was not fully assessed. ...A chromosomal aberration assay was also performed on Benzonatate and BBA. In the reverse mutation assay, Benzonatate a …
The nonclinical and clinical efficacy of Benzonatate has been demonstrated over the last 60 years, but its safety was not fully asses …
18 results