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Page 1
Benzonatate as a local anesthetic.
McGuire A, Ostertag-Hill CA, Aizik G, Li Y, Kohane DS. McGuire A, et al. PLoS One. 2023 Apr 12;18(4):e0284401. doi: 10.1371/journal.pone.0284401. eCollection 2023. PLoS One. 2023. PMID: 37043508 Free PMC article.
Based on structural similarities to known local anesthetics and recent findings of benzonatate exerting local anesthetic-like effects on voltage-gated sodium channels in vitro, we hypothesized that benzonatate will act as a local anesthetic to yield peripheral nerve …
Based on structural similarities to known local anesthetics and recent findings of benzonatate exerting local anesthetic-like effects …
Benzonatate Exposure Trends and Adverse Events.
Kim I, Goulding M, Tian F, Karami S, Pham T, Cheng C, Biehl A, Muñoz M. Kim I, et al. Pediatrics. 2022 Dec 1;150(6):e2022057779. doi: 10.1542/peds.2022-057779. Pediatrics. 2022. PMID: 36377394 Free PMC article.
There were few cases annually of serious AEs with benzonatate in children. CONCLUSIONS: There were rising patterns of unintentional ingestion of benzonatate in children 0 to 5 years old and intentional benzonatate ingestion in children 10 to 16 years old. Rat …
There were few cases annually of serious AEs with benzonatate in children. CONCLUSIONS: There were rising patterns of unintentional i …
Benzonatate inhibition of voltage-gated sodium currents.
Evans MS, Maglinger GB, Fletcher AM, Johnson SR. Evans MS, et al. Neuropharmacology. 2016 Feb;101:179-87. doi: 10.1016/j.neuropharm.2015.09.020. Epub 2015 Sep 16. Neuropharmacology. 2016. PMID: 26386152
Local anesthetics inhibit voltage-gated sodium channels, but there are no reports of whether benzonatate affects these channels. Our hypothesis is that benzonatate inhibits Nav1.7 voltage-gated sodium channels. ...We found that, like local anesthetics, benzonatat …
Local anesthetics inhibit voltage-gated sodium channels, but there are no reports of whether benzonatate affects these channels. Our …
Drugs for cough.
[No authors listed] [No authors listed] Med Lett Drugs Ther. 2018 Dec 17;60(1562):206-208. Med Lett Drugs Ther. 2018. PMID: 30625123 Review. No abstract available.
In brief: benzonatate warning.
[No authors listed] [No authors listed] Med Lett Drugs Ther. 2011 Feb 7;53(1357):9. Med Lett Drugs Ther. 2011. PMID: 21304443 Review. No abstract available.
Benzonatate Toxicity: Nothing to Cough At.
Bishop-Freeman SC, Shonsey EM, Friederich LW, Beuhler MC, Winecker RE. Bishop-Freeman SC, et al. J Anal Toxicol. 2017 Jun 1;41(5):461-463. doi: 10.1093/jat/bkx021. J Anal Toxicol. 2017. PMID: 28334901 No abstract available.
The Antitussive Benzonatate Is Not Tumorigenic in Rodent Carcinogenicity Studies.
Teo S, Paranjpe M, Mckeon M, Mann P, Lee S, LaRock R, Brown T. Teo S, et al. Toxicol Pathol. 2018 Aug;46(6):683-692. doi: 10.1177/0192623318789130. Epub 2018 Jul 22. Toxicol Pathol. 2018. PMID: 30033829
Benzonatate is a peripheral oral antitussive that dampens the activity of cough stretch receptors. ...Retinal atrophy was observed in male rats at 30 mg/kg/day, but the incidence was within historical control data range and not related to benzonatate. In conclusion, …
Benzonatate is a peripheral oral antitussive that dampens the activity of cough stretch receptors. ...Retinal atrophy was observed in …
Analysis of benzonatate overdoses among adults and children from 1969-2010 by the United States Food and Drug Administration.
McLawhorn MW, Goulding MR, Gill RK, Michele TM. McLawhorn MW, et al. Pharmacotherapy. 2013 Jan;33(1):38-43. doi: 10.1002/phar.1153. Pharmacotherapy. 2013. PMID: 23307543
STUDY OBJECTIVE: To augment the December 2010 United States Food and Drug Administration (FDA) Drug Safety Communication on accidental ingestion of benzonatate in children less than 10 years old by summarizing data on emergency department visits, benzonatate exposur …
STUDY OBJECTIVE: To augment the December 2010 United States Food and Drug Administration (FDA) Drug Safety Communication on accidental inges …
Genotoxicity assessment of the novel antitussive agent Benzonatate and its major metabolite.
Teo S, Madraymootoo W, Dakoulas E, Kulkarni R, McKeon M. Teo S, et al. Mutat Res Genet Toxicol Environ Mutagen. 2018 May-Jun;829-830:19-25. doi: 10.1016/j.mrgentox.2018.03.007. Epub 2018 Mar 21. Mutat Res Genet Toxicol Environ Mutagen. 2018. PMID: 29704989
The nonclinical and clinical efficacy of Benzonatate has been demonstrated over the last 60 years, but its safety was not fully assessed. ...A chromosomal aberration assay was also performed on Benzonatate and BBA. In the reverse mutation assay, Benzonatate a …
The nonclinical and clinical efficacy of Benzonatate has been demonstrated over the last 60 years, but its safety was not fully asses …
Cardiac Arrest Due to Benzonatate Overdose.
Jin C, Zahid E, Sherazi A, Majumder MR, Bedi P. Jin C, et al. Am J Case Rep. 2019 May 3;20:640-642. doi: 10.12659/AJCR.915151. Am J Case Rep. 2019. PMID: 31048669 Free PMC article.
BACKGROUND Benzonatate is one of the most widely prescribed nonnarcotic antitussives to relieve cough symptoms. ...It was reported that approximately 2 hours prior to her presentation; the patient had ingested less than 30 pills of benzonatate 200 mg capsules with a …
BACKGROUND Benzonatate is one of the most widely prescribed nonnarcotic antitussives to relieve cough symptoms. ...It was reported th …
32 results