Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1956 2
1957 2
1958 2
1959 3
1961 1
1962 1
1963 1
1967 2
1969 2
1980 1
1981 2
1982 1
1986 1
1988 1
1990 1
1992 1
1995 1
1997 1
1998 2
2001 1
2004 1
2008 1
2009 2
2010 1
2011 3
2012 2
2013 2
2015 2
2016 4
2017 1
2018 4
2019 3
2020 2
2021 5
2022 5
2023 4
2024 1

Text availability

Article attribute

Article type

Publication date

Search Results

67 results

Results by year

Filters applied: . Clear all
Page 1
Benzonatate Safety and Effectiveness: A Systematic Review of the Literature.
Costantino RC, Leonard J, Gorman EF, Ventura D, Baltz A, Gressler LE. Costantino RC, et al. Ann Pharmacother. 2023 Oct;57(10):1221-1236. doi: 10.1177/10600280221135750. Epub 2023 Jan 23. Ann Pharmacother. 2023. PMID: 36688284 Review.
OBJECTIVE: To review the available literature regarding the treatment effects and efficacy of benzonatate needed to better inform patients, providers, and regulators evaluating its role in modern medical therapies. ...CONCLUSIONS: Rising safety concerns should bring closer …
OBJECTIVE: To review the available literature regarding the treatment effects and efficacy of benzonatate needed to better inform pat …
Drugs for cough.
[No authors listed] [No authors listed] Med Lett Drugs Ther. 2018 Dec 17;60(1562):206-208. Med Lett Drugs Ther. 2018. PMID: 30625123 Review. No abstract available.
Benzonatate as a local anesthetic.
McGuire A, Ostertag-Hill CA, Aizik G, Li Y, Kohane DS. McGuire A, et al. PLoS One. 2023 Apr 12;18(4):e0284401. doi: 10.1371/journal.pone.0284401. eCollection 2023. PLoS One. 2023. PMID: 37043508 Free PMC article.
Based on structural similarities to known local anesthetics and recent findings of benzonatate exerting local anesthetic-like effects on voltage-gated sodium channels in vitro, we hypothesized that benzonatate will act as a local anesthetic to yield peripheral nerve …
Based on structural similarities to known local anesthetics and recent findings of benzonatate exerting local anesthetic-like effects …
Benzonatate inhibition of voltage-gated sodium currents.
Evans MS, Maglinger GB, Fletcher AM, Johnson SR. Evans MS, et al. Neuropharmacology. 2016 Feb;101:179-87. doi: 10.1016/j.neuropharm.2015.09.020. Epub 2015 Sep 16. Neuropharmacology. 2016. PMID: 26386152
Local anesthetics inhibit voltage-gated sodium channels, but there are no reports of whether benzonatate affects these channels. Our hypothesis is that benzonatate inhibits Nav1.7 voltage-gated sodium channels. ...We found that, like local anesthetics, benzonatat …
Local anesthetics inhibit voltage-gated sodium channels, but there are no reports of whether benzonatate affects these channels. Our …
Benzonatate Exposure Trends and Adverse Events.
Kim I, Goulding M, Tian F, Karami S, Pham T, Cheng C, Biehl A, Muñoz M. Kim I, et al. Pediatrics. 2022 Dec 1;150(6):e2022057779. doi: 10.1542/peds.2022-057779. Pediatrics. 2022. PMID: 36377394 Free PMC article.
There were few cases annually of serious AEs with benzonatate in children. CONCLUSIONS: There were rising patterns of unintentional ingestion of benzonatate in children 0 to 5 years old and intentional benzonatate ingestion in children 10 to 16 years old. Rat …
There were few cases annually of serious AEs with benzonatate in children. CONCLUSIONS: There were rising patterns of unintentional i …
Management of cough in advanced cancer.
Estfan B, LeGrand S. Estfan B, et al. J Support Oncol. 2004 Nov-Dec;2(6):523-7. J Support Oncol. 2004. PMID: 16302303 Review.
We prefer hydrocodone as first-line empiric treatment, but when the cough is resistant to this, our second-line therapy would be the addition or substitution of benzonatate. Bronchodilators, as well as corticosteroids, are commonly employed in our practice and can be usefu …
We prefer hydrocodone as first-line empiric treatment, but when the cough is resistant to this, our second-line therapy would be the additio …
In brief: benzonatate warning.
[No authors listed] [No authors listed] Med Lett Drugs Ther. 2011 Feb 7;53(1357):9. Med Lett Drugs Ther. 2011. PMID: 21304443 Review. No abstract available.
Benzonatate Toxicity: Nothing to Cough At.
Bishop-Freeman SC, Shonsey EM, Friederich LW, Beuhler MC, Winecker RE. Bishop-Freeman SC, et al. J Anal Toxicol. 2017 Jun 1;41(5):461-463. doi: 10.1093/jat/bkx021. J Anal Toxicol. 2017. PMID: 28334901 No abstract available.
Nebulized lidocaine in the treatment of intractable cough.
Truesdale K, Jurdi A. Truesdale K, et al. Am J Hosp Palliat Care. 2013 Sep;30(6):587-9. doi: 10.1177/1049909112458577. Epub 2012 Sep 9. Am J Hosp Palliat Care. 2013. PMID: 22964341 Review.
Pharmacological treatments include dextramethorphan, opioid cough suppressants, benzonatate, inhaled ipratropium, and guaifenesin. Successful cough suppression has also been demonstrated in several studies with the use of nebulized lidocaine. ...
Pharmacological treatments include dextramethorphan, opioid cough suppressants, benzonatate, inhaled ipratropium, and guaifenesin. Su …
Patterns of Cough Medication Prescribing among Patients with Chronic Cough in Florida: 2012-2021.
Yang S, Huang S, Hincapie-Castillo JM, Ke X, Ding H, Schelfhout J, Sher MR, Jones B, Wilson DL, Lo-Ciganic WH. Yang S, et al. J Clin Med. 2023 Sep 29;12(19):6286. doi: 10.3390/jcm12196286. J Clin Med. 2023. PMID: 37834931 Free PMC article.
In the GBTM analysis, we calculated the number of monthly prescriptions for any CMs (excluding gabapentinoids) during the 12 months from the first qualifying cough event to identify distinct utilization trajectories. From 2012 to 2021, benzonatate (9.6% to 26.1%), dextrome …
In the GBTM analysis, we calculated the number of monthly prescriptions for any CMs (excluding gabapentinoids) during the 12 months from the …
67 results