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Reinforcing and subjective effects of several anorectics in normal human volunteers.
Chait LD, Uhlenhuth EH, Johanson CE. Chait LD, et al. J Pharmacol Exp Ther. 1987 Sep;242(3):777-83. J Pharmacol Exp Ther. 1987. PMID: 3656112 Clinical Trial.
A discrete-trial choice procedure was used to examine the reinforcing and subjective effects of four anorectic drugs (mazindol, benzphetamine, phenylpropanolamine and phenmetrazine) in groups of normal healthy adults. For each experiment, subjects first sampled placebo and …
A discrete-trial choice procedure was used to examine the reinforcing and subjective effects of four anorectic drugs (mazindol, benzpheta …
Selective impairment of drug-metabolizing enzymes in pig liver during subchronic dietary exposure to aflatoxin B1.
Meissonnier GM, Laffitte J, Loiseau N, Benoit E, Raymond I, Pinton P, Cossalter AM, Bertin G, Oswald IP, Galtier P. Meissonnier GM, et al. Food Chem Toxicol. 2007 Nov;45(11):2145-54. doi: 10.1016/j.fct.2007.05.012. Epub 2007 Jun 2. Food Chem Toxicol. 2007. PMID: 17614185 Clinical Trial.
By comparison, mild degenerative hepatic changes, no hepatic dysfunction but a similar pattern of liver P450 enzymes activity without changes in P450 3A expression were observed in pigs exposed to 867 microg AFB1/kg of feed. Benzphetamine and aminopyrine N-demethylase acti …
By comparison, mild degenerative hepatic changes, no hepatic dysfunction but a similar pattern of liver P450 enzymes activity without change …