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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1966 1
1971 1
1972 5
1973 6
1974 5
1975 5
1976 3
1977 4
1978 1
1979 4
1982 2
1983 4
1984 3
1986 2
1987 7
1988 3
1989 7
1990 5
1991 5
1992 2
1993 4
1994 4
1995 2
1996 5
1997 4
1998 2
1999 1
2000 4
2001 4
2002 2
2003 3
2004 3
2006 4
2007 4
2008 1
2010 1
2013 1
2014 1
2015 1
2016 1
2018 1
2020 1
2022 0
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126 results
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Page 1
Efficacy of Low-Dose Amitriptyline for Chronic Low Back Pain: A Randomized Clinical Trial.
Urquhart DM, Wluka AE, van Tulder M, Heritier S, Forbes A, Fong C, Wang Y, Sim MR, Gibson SJ, Arnold C, Cicuttini FM. Urquhart DM, et al. JAMA Intern Med. 2018 Nov 1;178(11):1474-1481. doi: 10.1001/jamainternmed.2018.4222. JAMA Intern Med. 2018. PMID: 30285054 Free PMC article. Clinical Trial.
INTERVENTION: Low-dose amitriptyline (25 mg/d) or an active comparator (benztropine mesylate, 1 mg/d) for 6 months. MAIN OUTCOMES AND MEASURES: The primary outcome was pain intensity measured at 3 and 6 months using the visual analog scale and Descriptor Differential Scale …
INTERVENTION: Low-dose amitriptyline (25 mg/d) or an active comparator (benztropine mesylate, 1 mg/d) for 6 months. MAIN OUTCOMES AND …
The effect of benztropine on haloperidol-induced dystonia, clinical efficacy and pharmacokinetics: a prospective, double-blind trial.
Goff DC, Arana GW, Greenblatt DJ, Dupont R, Ornsteen M, Harmatz JS, Shader RI. Goff DC, et al. J Clin Psychopharmacol. 1991 Apr;11(2):106-12. J Clin Psychopharmacol. 1991. PMID: 2056136 Clinical Trial.
Twenty-nine inpatients with major psychotic disorders were treated for 14 days with a clinician-determined dose of haloperidol and with either benztropine or placebo given by double-blind random assignment on days 1 through 7. No differences were noted in haloperidol mean …
Twenty-nine inpatients with major psychotic disorders were treated for 14 days with a clinician-determined dose of haloperidol and with eith …
Efficacy of benztropine therapy for drooling.
Camp-Bruno JA, Winsberg BG, Green-Parsons AR, Abrams JP. Camp-Bruno JA, et al. Dev Med Child Neurol. 1989 Jun;31(3):309-19. doi: 10.1111/j.1469-8749.1989.tb04000.x. Dev Med Child Neurol. 1989. PMID: 2666205 Clinical Trial.
This study assessed the efficacy of synthetic anticholinergic benztropine and incidence of side-effects in 20 developmentally-disabled patients with severe drooling. The double-blind, placebo-controlled, crossover protocol included one-week baseline, two-week placebo and t …
This study assessed the efficacy of synthetic anticholinergic benztropine and incidence of side-effects in 20 developmentally-disable …
Benztropine for the relief of acute non-traumatic neck pain (wry neck): a randomised trial.
Asha SE, Kerr A, Jones K, McAlpine A. Asha SE, et al. Emerg Med J. 2015 Aug;32(8):616-9. doi: 10.1136/emermed-2014-204317. Epub 2014 Nov 20. Emerg Med J. 2015. PMID: 25414475 Clinical Trial.
RESULTS: Thirty participants were enrolled, 15 randomised to placebo and 15 to benztropine. Pain scores at 30 min were lower in those allocated to benztropine, but the difference was neither statistically nor clinically significant (0.6 points, 95% CI -0.8 to 1.8, p …
RESULTS: Thirty participants were enrolled, 15 randomised to placebo and 15 to benztropine. Pain scores at 30 min were lower in those …
A comparative study of haloperidol and chlorpromazine in terms of clinical effects and therapeutic reversal with benztropine in schizophrenia. Theoretical implications for potency differences among neuroleptics.
Singh MM, Kay SR. Singh MM, et al. Psychopharmacologia. 1975 Aug 21;43(2):103-13. doi: 10.1007/BF00421012. Psychopharmacologia. 1975. PMID: 1103205 Clinical Trial.
The data failed to support the clinical validity of the distinction often made between "sedative" and "activating" neuroleptics. Consistent with previous reports, benztropine had the effect of diminishing therapeutic response to both neuroleptics. ...The slowness and lesse …
The data failed to support the clinical validity of the distinction often made between "sedative" and "activating" neuroleptics. Consistent …
A randomized placebo-controlled trial of desipramine, cognitive behavioral therapy, and active placebo therapy for low back pain.
Gould HM, Atkinson JH, Chircop-Rollick T, D'Andrea J, Garfin S, Patel SM, Funk SD, Capparelli EV, Penzien DB, Wallace M, Weickgenanta AL, Slater M, Rutledge T. Gould HM, et al. Pain. 2020 Jun;161(6):1341-1349. doi: 10.1097/j.pain.0000000000001834. Pain. 2020. PMID: 32068667 Clinical Trial.
Participants (n = 142) were patients experiencing daily chronic back pain at an intensity of 4/10 who were randomized to a single-center, double-blind, 12-week, 4-arm, parallel groups controlled clinical trial of (1) low concentration desipramine titrated to reach a serum concent …
Participants (n = 142) were patients experiencing daily chronic back pain at an intensity of 4/10 who were randomized to a single-center, do …
Anticholinergic effects on memory: benztropine versus amantadine.
Gelenberg AJ, Van Putten T, Lavori PW, Wojcik JD, Falk WE, Marder S, Galvin-Nadeau M, Spring B, Mohs RC, Brotman AW. Gelenberg AJ, et al. J Clin Psychopharmacol. 1989 Jun;9(3):180-5. J Clin Psychopharmacol. 1989. PMID: 2661606 Clinical Trial.
To evaluate anticholinergic effects on cognition and other functions, we studied 60 healthy volunteers in a double-blind crossover trial of two antiparkinsonian agents, benztropine and amantadine. Benztropine 4 mg/day, but not amantadine 200 mg/day, impaired free re …
To evaluate anticholinergic effects on cognition and other functions, we studied 60 healthy volunteers in a double-blind crossover trial of …
Pharmacologic characterization of tardive dyskinesia.
Lieberman J, Pollack S, Lesser M, Kane J. Lieberman J, et al. J Clin Psychopharmacol. 1988 Aug;8(4):254-60. J Clin Psychopharmacol. 1988. PMID: 3209717 Clinical Trial.
To evaluate pharmacologic response in TD syndromes, 15 patients underwent single dose acute administration of four different drugs: a DA agonist (bromocriptine 5 mg orally), a DA antagonist (haloperidol 5 mg intravenously), a cholinergic agonist (physostigmine 2 mg intravenously) …
To evaluate pharmacologic response in TD syndromes, 15 patients underwent single dose acute administration of four different drugs: a DA ago …
Benztropine pretreatment does not affect responses to acute cocaine administration in human volunteers.
Penetar DM, Looby AR, Su Z, Lundahl LH, Erös-Sarnyai M, McNeil JF, Lukas SE. Penetar DM, et al. Hum Psychopharmacol. 2006 Dec;21(8):549-59. doi: 10.1002/hup.810. Hum Psychopharmacol. 2006. PMID: 17080501 Clinical Trial.
Benztropine (Cogentin ) was evaluated for its ability to block cocaine's physiological and subjective effects in humans. ...Responses to cocaine with and without benztropine pretreatment were similar: benztropine did not change cocaine's effects. ...
Benztropine (Cogentin ) was evaluated for its ability to block cocaine's physiological and subjective effects in humans. ...Responses
Double-blind maintenance safety and effectiveness findings from the Treatment of Early-Onset Schizophrenia Spectrum (TEOSS) study.
Findling RL, Johnson JL, McClellan J, Frazier JA, Vitiello B, Hamer RM, Lieberman JA, Ritz L, McNamara NK, Lingler J, Hlastala S, Pierson L, Puglia M, Maloney AE, Kaufman EM, Noyes N, Sikich L. Findling RL, et al. J Am Acad Child Adolesc Psychiatry. 2010 Jun;49(6):583-94; quiz 632. doi: 10.1016/j.jaac.2010.03.013. Epub 2010 May 1. J Am Acad Child Adolesc Psychiatry. 2010. PMID: 20494268 Free PMC article. Clinical Trial.
METHOD: Patients (8 to 19 years old) who had improved during an 8-week, randomized, double-blind acute trial of olanzapine, risperidone, or molindone (plus benztropine) were eligible to continue on the same medication for up to 44 additional weeks under double-blind condit …
METHOD: Patients (8 to 19 years old) who had improved during an 8-week, randomized, double-blind acute trial of olanzapine, risperidone, or …
126 results