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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1918 1
1922 1
1923 1
1925 2
1928 2
1933 2
1934 1
1935 2
1940 1
1942 1
1944 3
1945 3
1946 6
1947 14
1948 30
1949 21
1950 17
1951 17
1952 15
1953 30
1954 22
1955 42
1956 37
1957 23
1958 33
1959 30
1960 26
1961 31
1962 48
1963 141
1964 276
1965 226
1966 236
1967 346
1968 497
1969 595
1970 582
1971 647
1972 655
1973 631
1974 684
1975 624
1976 548
1977 506
1978 469
1979 488
1980 483
1981 438
1982 457
1983 536
1984 603
1985 617
1986 653
1987 582
1988 555
1989 622
1990 665
1991 619
1992 575
1993 536
1994 533
1995 523
1996 488
1997 492
1998 487
1999 427
2000 453
2001 464
2002 451
2003 418
2004 480
2005 467
2006 558
2007 518
2008 546
2009 568
2010 595
2011 616
2012 581
2013 613
2014 581
2015 559
2016 547
2017 515
2018 530
2019 509
2020 539
2021 478
2022 526
2023 457
2024 468
2025 441
2026 157

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31,506 results

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Page 1
Renal Tubular Acidosis and Management Strategies: A Narrative Review.
Palmer BF, Kelepouris E, Clegg DJ. Palmer BF, et al. Adv Ther. 2021 Feb;38(2):949-968. doi: 10.1007/s12325-020-01587-5. Epub 2020 Dec 26. Adv Ther. 2021. PMID: 33367987 Free PMC article. Review.
Renal tubular acidosis (RTA) occurs when the kidneys are unable to maintain normal acid-base homeostasis because of tubular defects in acid excretion or bicarbonate ion reabsorption. Using illustrative clinical cases, this review describes the main types of RTA obse …
Renal tubular acidosis (RTA) occurs when the kidneys are unable to maintain normal acid-base homeostasis because of tubular defects in acid …
Why bicarbonate?
Casey JR. Casey JR. Biochem Cell Biol. 2006 Dec;84(6):930-9. doi: 10.1139/o06-184. Biochem Cell Biol. 2006. PMID: 17215880 Review.
Bicarbonate is a simple single carbon molecule that plays surprisingly important roles in diverse biological processes. ...This review provides a wide-ranging view of the biochemistry of bicarbonate and its membrane transporters, revealing what makes the study of …
Bicarbonate is a simple single carbon molecule that plays surprisingly important roles in diverse biological processes. ...This revie …
Bacterial β-carbonic anhydrases.
Ferraroni M. Ferraroni M. Enzymes. 2024;55:65-91. doi: 10.1016/bs.enz.2024.05.009. Epub 2024 Aug 16. Enzymes. 2024. PMID: 39222999 Review.
An Asp-Arg dyad is thought to play a key role in the pH-induced catalytic switch regulating the opening and closing of the active site in class II beta-CAs, by displacing the zinc-bound solvent molecule. An allosteric site well-suited for bicarbonate stabilizes the inactiv …
An Asp-Arg dyad is thought to play a key role in the pH-induced catalytic switch regulating the opening and closing of the active site in cl …
SLC4A transporters.
Choi I. Choi I. Curr Top Membr. 2012;70:77-103. doi: 10.1016/B978-0-12-394316-3.00003-X. Curr Top Membr. 2012. PMID: 23177984 Free PMC article.
SLC4A gene family proteins include bicarbonate transporters that move HCO(3)(-) across the plasma membrane and regulate intracellular pH and transepithelial movement of acid-base equivalents. ...Recent advances in structure/function analysis have also provided valuable inf …
SLC4A gene family proteins include bicarbonate transporters that move HCO(3)(-) across the plasma membrane and regulate intracellular …
The Fundamental Role of Bicarbonate Transporters and Associated Carbonic Anhydrase Enzymes in Maintaining Ion and pH Homeostasis in Non-Secretory Organs.
Lee D, Hong JH. Lee D, et al. Int J Mol Sci. 2020 Jan 4;21(1):339. doi: 10.3390/ijms21010339. Int J Mol Sci. 2020. PMID: 31947992 Free PMC article. Review.
The bicarbonate ion has a fundamental role in vital systems. Impaired bicarbonate transport leads to various diseases, including immune disorders, cystic fibrosis, tumorigenesis, kidney diseases, brain dysfunction, tooth fracture, ischemic reperfusion injury, …
The bicarbonate ion has a fundamental role in vital systems. Impaired bicarbonate transport leads to various diseases, …
The effects of bathing in neutral bicarbonate ion water.
Yamazaki T, Ushikoshi-Nakayama R, Shakya S, Omagari D, Matsumoto N, Nukuzuma C, Komatsu T, Lee MC, Inoue H, Saito I. Yamazaki T, et al. Sci Rep. 2021 Nov 8;11(1):21789. doi: 10.1038/s41598-021-01285-4. Sci Rep. 2021. PMID: 34750450 Free PMC article. Clinical Trial.
The mechanism by which it does so is unclear, but we hypothesized that it involves bicarbonate ions. BALB/c mice were bathed in neutral bicarbonate ionized water (NBIW) and showed increased blood bicarbonate levels and blood flow via phosphorylation of periph …
The mechanism by which it does so is unclear, but we hypothesized that it involves bicarbonate ions. BALB/c mice were bathed in neutr …
Proximal renal tubular acidosis.
Quigley R. Quigley R. J Nephrol. 2006 Mar-Apr;19 Suppl 9:S41-5. J Nephrol. 2006. PMID: 16736440 Review.
The proximal tubule reabsorbs approximately 80% of the filtered load of bicarbonate. Defects in the process of bicarbonate reabsorption result in loss of bicarbonate and proximal renal tubular acidosis. ...This review will discuss the mechanisms that cause de …
The proximal tubule reabsorbs approximately 80% of the filtered load of bicarbonate. Defects in the process of bicarbonate rea …
Bicarbonate-regulated soluble adenylyl cyclase.
Wuttke MS, Buck J, Levin LR. Wuttke MS, et al. JOP. 2001 Jul;2(4 Suppl):154-8. JOP. 2001. PMID: 11875252 Review.
Thus, sAC defines an independently regulated cAMP signaling system within mammalian cells. sAC is directly stimulated by bicarbonate ion both in vivo in heterologously expressing cells and in vitro using purified protein. sAC appears to be the predominant form of ad …
Thus, sAC defines an independently regulated cAMP signaling system within mammalian cells. sAC is directly stimulated by bicarbonate …
Buffers in intravenous solutions: is the source of bicarbonate a source of confusion?
Ulsamer A, Betbesé AJ, Campos-Gómez A, Centelles J, Domínguez E, Iglesias-Serret D, Lorente-Olazábal JV, Pérez-Fernández XL, Sabater-Riera J, Rigo-Bonnin R, Kellum JA. Ulsamer A, et al. Crit Care. 2025 Nov 26;29(1):539. doi: 10.1186/s13054-025-05780-2. Crit Care. 2025. PMID: 41299755 Free PMC article. Review.
There is a widespread belief that organic sodium salts included in intravenous solutions serve as bicarbonate precursors, and that this mechanism explains their effects on plasma pH. We aimed to explain why the effect of organic anions, such as citrate, acetate, gluconate, …
There is a widespread belief that organic sodium salts included in intravenous solutions serve as bicarbonate precursors, and that th …
Hypocapnic hypothesis of Leigh disease.
Pronicka E. Pronicka E. Med Hypotheses. 2017 Apr;101:23-27. doi: 10.1016/j.mehy.2017.01.016. Epub 2017 Feb 1. Med Hypotheses. 2017. PMID: 28351484 Free article.
Inside mitochondria, the pH signal of high pH/low bicarbonate ion (HCO(-)(3)) is transmitted by soluble adenyl cyclase (sAC) through cAMP dependent manner. ...
Inside mitochondria, the pH signal of high pH/low bicarbonate ion (HCO(-)(3)) is transmitted by soluble adenyl cyclase (sAC) t …
31,506 results
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