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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1966 6
1967 2
1968 14
1969 7
1970 9
1971 8
1972 16
1973 15
1974 21
1975 15
1976 14
1977 10
1978 10
1979 5
1980 10
1981 4
1982 4
1983 19
1984 22
1985 25
1986 29
1987 20
1988 31
1989 34
1990 37
1991 44
1992 35
1993 38
1994 42
1995 56
1996 35
1997 45
1998 50
1999 30
2000 37
2001 43
2002 44
2003 47
2004 46
2005 32
2006 43
2007 49
2008 40
2009 40
2010 48
2011 54
2012 52
2013 61
2014 60
2015 52
2016 58
2017 59
2018 49
2019 42
2020 44
2021 43
2022 16
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1,690 results
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Clinical and cost-effectiveness of oral sodium bicarbonate therapy for older patients with chronic kidney disease and low-grade acidosis (BiCARB): a pragmatic randomised, double-blind, placebo-controlled trial.
BiCARB study group. BiCARB study group. BMC Med. 2020 Apr 9;18(1):91. doi: 10.1186/s12916-020-01542-9. BMC Med. 2020. PMID: 32268897 Free PMC article. Clinical Trial.
BACKGROUND: Chronic kidney disease with metabolic acidosis is common in older people, but the effectiveness of oral sodium bicarbonate therapy in this group is unclear. We tested whether oral sodium bicarbonate provides net health benefit for older people with advan …
BACKGROUND: Chronic kidney disease with metabolic acidosis is common in older people, but the effectiveness of oral sodium bicarbonate
Extracellular buffer choice influences acid-base responses and gastrointestinal symptoms.
Peacock J, Sparks SA, Middlebrook I, Hilton NP, Tinnion D, Leach N, Saunders B, McNaughton LR. Peacock J, et al. Res Sports Med. 2021 Nov-Dec;29(6):505-516. doi: 10.1080/15438627.2021.1896517. Epub 2021 Mar 9. Res Sports Med. 2021. PMID: 33715526 Clinical Trial.
To compare the bicarbonate kinetics and gastrointestinal (GI) symptom responses between an equal dose of sodium bicarbonate and sodium citrate using delayed-release capsules. ...Blood bicarbonate ion (HCO(3)(-)) concentration, pH and GI symptoms were m …
To compare the bicarbonate kinetics and gastrointestinal (GI) symptom responses between an equal dose of sodium bicarbonate an …
The effects of bathing in neutral bicarbonate ion water.
Yamazaki T, Ushikoshi-Nakayama R, Shakya S, Omagari D, Matsumoto N, Nukuzuma C, Komatsu T, Lee MC, Inoue H, Saito I. Yamazaki T, et al. Sci Rep. 2021 Nov 8;11(1):21789. doi: 10.1038/s41598-021-01285-4. Sci Rep. 2021. PMID: 34750450 Free PMC article. Clinical Trial.
The mechanism by which it does so is unclear, but we hypothesized that it involves bicarbonate ions. BALB/c mice were bathed in neutral bicarbonate ionized water (NBIW) and showed increased blood bicarbonate levels and blood flow via phosphorylation of periph …
The mechanism by which it does so is unclear, but we hypothesized that it involves bicarbonate ions. BALB/c mice were bathed in neutr …
Pharmacokinetics and Pharmacodynamics of Esomeprazole/Sodium Bicarbonate Immediate-Release Capsules in Healthy Chinese Volunteers: A Cross-Over, Randomized Controlled Trial.
Jing S, Zhu Y, Liu W, Yang K, Hu L, Deng D, Lu C, Lin Y. Jing S, et al. Adv Ther. 2021 Mar;38(3):1660-1676. doi: 10.1007/s12325-021-01644-7. Epub 2021 Feb 11. Adv Ther. 2021. PMID: 33575950 Clinical Trial.
The purpose of this study is to compare the safety, pharmacokinetics (PK) and pharmacodynamics (PD) of an immediate-release capsule formulation containing esomeprazole 20 mg and sodium bicarbonate 1100 mg (IR-ESO) compared to those of the esomeprazole delayed release table …
The purpose of this study is to compare the safety, pharmacokinetics (PK) and pharmacodynamics (PD) of an immediate-release capsule formulat …
Bicarbonate Unlocks the Ergogenic Action of Ketone Monoester Intake in Endurance Exercise.
Poffé C, Ramaekers M, Bogaerts S, Hespel P. Poffé C, et al. Med Sci Sports Exerc. 2021 Feb 1;53(2):431-441. doi: 10.1249/MSS.0000000000002467. Med Sci Sports Exerc. 2021. PMID: 32735112 Free PMC article. Clinical Trial.

In KE, blood pH concomitantly dropped from 7.43 to 7.36 whereas bicarbonate decreased from 25.5 to 20.5 mM (both P < 0.001 vs CON). ...Gastrointestinal symptoms were similar between groups. DISCUSSION: The coingestion of oral bicarbonate and KE enhances high-inte

In KE, blood pH concomitantly dropped from 7.43 to 7.36 whereas bicarbonate decreased from 25.5 to 20.5 mM (both P < 0.001 vs CON)

Effect of pre-operative bicarbonate infusion on maternal and perinatal outcomes among women with obstructed labour in Mbale hospital: A double blind randomized controlled trial.
Musaba MW, Wandabwa JN, Ndeezi G, Weeks AD, Mukunya D, Waako P, Nankabirwa V, Mugabe KT, Semakula D, Tumwine JK, Barageine JK. Musaba MW, et al. PLoS One. 2021 Feb 9;16(2):e0245989. doi: 10.1371/journal.pone.0245989. eCollection 2021. PLoS One. 2021. PMID: 33561141 Free PMC article. Clinical Trial.
INTRODUCTION: Oral bicarbonate solution is known to improve both maternal and perinatal outcomes among women with abnormal labour (dystocia). ...INTERVENTION: A total of 477 women with OL were randomized to receive 50ml of 8.4% sodium bicarbonate (238 women) or 50 m …
INTRODUCTION: Oral bicarbonate solution is known to improve both maternal and perinatal outcomes among women with abnormal labour (dy …
Enteric-Coated Sodium Bicarbonate Attenuates Gastrointestinal Side-Effects.
Hilton NP, Leach NK, Craig MM, Sparks SA, McNaughton LR. Hilton NP, et al. Int J Sport Nutr Exerc Metab. 2020 Jan 1;30(1):62-68. doi: 10.1123/ijsnem.2019-0151. Int J Sport Nutr Exerc Metab. 2020. PMID: 31751936 Clinical Trial.
Enteric-formulated capsules can mitigate gastrointestinal (GI) side effects following sodium bicarbonate (NaHCO3) ingestion; however, it remains unclear how encapsulation alters postingestion symptoms and acid-base balance. ...Trained males (n = 14) ingested 300 mg/kg body …
Enteric-formulated capsules can mitigate gastrointestinal (GI) side effects following sodium bicarbonate (NaHCO3) ingestion; however, …
Effect of high bicarbonate hemodialysis solution on biochemical parameters and anthropometric indices.
Hefzollah F, Boushehri SN, Mahmudpour M. Hefzollah F, et al. Hemodial Int. 2020 Jul;24(3):317-322. doi: 10.1111/hdi.12842. Epub 2020 May 17. Hemodial Int. 2020. PMID: 32419310 Clinical Trial.
METHODS: Fifty-six hemodialysis patients were randomly enrolled in two groups: an intervention group that underwent hemodialysis for 6 months with high bicarbonate dialysate concentration (36 mmol/L, N = 26) and a control group that underwent hemodialysis using a bicarb
METHODS: Fifty-six hemodialysis patients were randomly enrolled in two groups: an intervention group that underwent hemodialysis for 6 month …
Effect of dialysate calcium concentrations on parathyroid hormone and calcium balance during a single dialysis session using bicarbonate hemodialysis: a crossover clinical trial.
Basile C, Libutti P, Di Turo AL, Vernaglione L, Casucci F, Losurdo N, Teutonico A, Lomonte C. Basile C, et al. Am J Kidney Dis. 2012 Jan;59(1):92-101. doi: 10.1053/j.ajkd.2011.08.033. Epub 2011 Oct 14. Am J Kidney Dis. 2012. PMID: 22000728 Clinical Trial.
BACKGROUND: In bicarbonate-based hemodialysis, dialysate total calcium (tCa) concentration may have effects on mineral metabolism. ...SETTING & PARTICIPANTS: 22 stable anuric uremic patients underwent three 4-hour bicarbonate hemodialysis sessions with the 3 dif …
BACKGROUND: In bicarbonate-based hemodialysis, dialysate total calcium (tCa) concentration may have effects on mineral metabolism. .. …
Exogenous ketosis increases blood and muscle oxygenation but not performance during exercise in hypoxia.
Poffé C, Robberechts R, Podlogar T, Kusters M, Debevec T, Hespel P. Poffé C, et al. Am J Physiol Regul Integr Comp Physiol. 2021 Dec 1;321(6):R844-R857. doi: 10.1152/ajpregu.00198.2021. Epub 2021 Oct 20. Am J Physiol Regul Integr Comp Physiol. 2021. PMID: 34668436 Clinical Trial.
From this perspective, we hypothesized that exogenous ketosis by oral intake of the ketone ester (R)-3-hydroxybutyl (R)-3-hydroxybutyrate (KE) may induce beneficial physiological effects during prolonged exercise in acute hypoxia. As we recently demonstrated KE to deplete blood …
From this perspective, we hypothesized that exogenous ketosis by oral intake of the ketone ester (R)-3-hydroxybutyl (R)-3-hydroxybutyrate (K …
1,690 results