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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1972 1
1973 4
1974 4
1975 17
1976 12
1977 5
1978 6
1979 2
1980 1
1981 13
1982 2
1983 4
1984 4
1985 1
1986 3
1987 4
1988 7
1989 5
1990 2
1991 4
1992 2
1993 4
1994 2
1995 3
1996 5
1997 3
1998 3
2000 1
2001 2
2003 1
2004 2
2005 2
2006 2
2007 2
2010 1
2012 5
2013 1
2014 1
2015 4
2016 3
2017 4
2018 4
2019 4
2020 6
2021 4
2022 3
2023 5
2024 5
2025 2
2026 1

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175 results

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Page 1
Prediction of Behavioral Improvement Through Resting-State Electroencephalography and Clinical Severity in a Randomized Controlled Trial Testing Bumetanide in Autism Spectrum Disorder.
Juarez-Martinez EL, Sprengers JJ, Cristian G, Oranje B, van Andel DM, Avramiea AE, Simpraga S, Houtman SJ, Hardstone R, Gerver C, Jan van der Wilt G, Mansvelder HD, Eijkemans MJC, Linkenkaer-Hansen K, Bruining H. Juarez-Martinez EL, et al. Biol Psychiatry Cogn Neurosci Neuroimaging. 2023 Mar;8(3):251-261. doi: 10.1016/j.bpsc.2021.08.009. Epub 2021 Sep 8. Biol Psychiatry Cogn Neurosci Neuroimaging. 2023. PMID: 34506972 Free article. Clinical Trial.
BACKGROUND: Mechanism-based treatments such as bumetanide are being repurposed for autism spectrum disorder. We recently reported beneficial effects on repetitive behavioral symptoms that might be related to regulating excitation-inhibition (E/I) balance in the brain. Here …
BACKGROUND: Mechanism-based treatments such as bumetanide are being repurposed for autism spectrum disorder. We recently reported ben …
Clarifications regarding bumetanide for neonatal seizures.
Staley KJ. Staley KJ. Epilepsia. 2022 Jul;63(7):1863-1867. doi: 10.1111/epi.17278. Epub 2022 May 26. Epilepsia. 2022. PMID: 35524444 Free PMC article. Clinical Trial.
A recent Phase II randomized, controlled trial of bumetanide as an adjunctive treatment for neonatal seizures showed a robust efficacy signal and no evidence of toxicity. Concerns regarding bumetanide as an adjunctive anticonvulsant are addressed here. An adequately …
A recent Phase II randomized, controlled trial of bumetanide as an adjunctive treatment for neonatal seizures showed a robust efficac …
Bumetanide. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use.
Ward A, Heel RC. Ward A, et al. Drugs. 1984 Nov;28(5):426-64. doi: 10.2165/00003495-198428050-00003. Drugs. 1984. PMID: 6391889 Review.
In acute pulmonary oedema, intravenous bumetanide produces a very rapid diuresis. Higher doses of bumetanide may be required (up to 15 mg/day) in patients with chronic renal failure or nephrotic syndrome. ...Combination with thiazide diuretics enhances the clinical …
In acute pulmonary oedema, intravenous bumetanide produces a very rapid diuresis. Higher doses of bumetanide may be required ( …
Bumetanide Treatment in 15 Children With Autism: A Randomised Waitlist-Control Study.
Fernell E, Landberg S, Miniscalco C, Fagerudd R, Johnels JÅ, Johnson M, Hadjikhani N, Gillberg C. Fernell E, et al. Acta Paediatr. 2025 Nov;114(11):2985-2992. doi: 10.1111/apa.70204. Epub 2025 Jun 26. Acta Paediatr. 2025. PMID: 40568982 Free PMC article. Clinical Trial.
AIM: Bumetanide, a diuretic, influences neuronal chloride homeostasis and potentially restores GABAergic inhibition and neuronal signalling balance. ...RESULTS: Two children had to be excluded in the first treatment period with bumetanide due to emerging behavioural …
AIM: Bumetanide, a diuretic, influences neuronal chloride homeostasis and potentially restores GABAergic inhibition and neuronal sign …
The genetics of loop diuretic effects.
Vormfelde SV, Brockmöller J. Vormfelde SV, et al. Pharmacogenomics J. 2012 Feb;12(1):45-53. doi: 10.1038/tpj.2010.68. Epub 2010 Sep 28. Pharmacogenomics J. 2012. PMID: 20877298 Clinical Trial.
We newly investigated five genetic polymorphisms in 95 healthy volunteers, who had ingested bumetanide, frusemide and torsemide. The subjects excreted means of 20.2 g sodium chloride, 2.87 g potassium and 261 mg calcium over 24 h. ...
We newly investigated five genetic polymorphisms in 95 healthy volunteers, who had ingested bumetanide, frusemide and torsemide. The …
Bumetanide in congestive heart failure.
Kourouklis C, Christensen O, Augoustakis D. Kourouklis C, et al. Curr Med Res Opin. 1976;4(6):422-31. doi: 10.1185/03007997609111998. Curr Med Res Opin. 1976. PMID: 793779 Clinical Trial.
Bumetanide, a new diuretic exerting its major effect on the ascending limb of the loop of Henle, was evaluated in 20 patients with congestive heart failure. ...The results after 3 and 8 days' treatment showed that bumetanide caused a significant diuresis, an increas …
Bumetanide, a new diuretic exerting its major effect on the ascending limb of the loop of Henle, was evaluated in 20 patients with co …
Clinical trial of bumetanide versus furosemide in patients with congestive heart failure.
Konecke LL. Konecke LL. J Clin Pharmacol. 1981 Nov-Dec;21(11):688-90. doi: 10.1002/j.1552-4604.1981.tb05684.x. J Clin Pharmacol. 1981. PMID: 7040496 Clinical Trial.
A clinical trial was conducted in open, randomized, parallel fashion to determine the effectiveness and safety of bumetanide compared with those of furosemide in 42 outpatients with edema due to congestive heart failure. ...Both diuretics proved equally effective in reduci …
A clinical trial was conducted in open, randomized, parallel fashion to determine the effectiveness and safety of bumetanide compared …
Bumetanide oral solution for the treatment of children and adolescents with autism spectrum disorder: Results from two randomized phase III studies.
Fuentes J, Parellada M, Georgoula C, Oliveira G, Marret S, Crutel V, Albarran C, Lambert E, Pénélaud PF, Ravel D, Ben Ari Y. Fuentes J, et al. Autism Res. 2023 Oct;16(10):2021-2034. doi: 10.1002/aur.3005. Epub 2023 Oct 4. Autism Res. 2023. PMID: 37794745 Clinical Trial.
In both studies, patients were randomized to receive bumetanide oral solution twice daily (BID) or placebo BID during a 6-month double-blind treatment period. ...In both studies, treatment-emergent adverse events that occurred more frequently with bumetanide than pl …
In both studies, patients were randomized to receive bumetanide oral solution twice daily (BID) or placebo BID during a 6-month doubl …
A comparative randomized double-blind clinical trial of bumetanide and furosemide in congestive cardiac failure and other edema states.
Sagar S, Sharma BK, Sharma PL, Wahi PL. Sagar S, et al. Int J Clin Pharmacol Ther Toxicol. 1984 Sep;22(9):473-8. Int J Clin Pharmacol Ther Toxicol. 1984. PMID: 6389378 Clinical Trial.
In addition intravenous bumetanide was studied in 14 patients of congestive cardiac failure and nephrotic syndrome to determine the onset, peak and duration of action. ...Bumetanide was well tolerated by patients and is on a weight basis the most potent diuretic ava …
In addition intravenous bumetanide was studied in 14 patients of congestive cardiac failure and nephrotic syndrome to determine the o …
Bumetanide and furosemide in heart failure.
Brater DC, Day B, Burdette A, Anderson S. Brater DC, et al. Kidney Int. 1984 Aug;26(2):183-9. doi: 10.1038/ki.1984.153. Kidney Int. 1984. PMID: 6503136 Free article. Clinical Trial.
In both CHF and normal subjects, more bumetanide than furosemide was absorbed. The elimination half-life of furosemide was approximately twice that of bumetanide, and both were about two times longer than respective values in normal subjects. ...In patients with CHF …
In both CHF and normal subjects, more bumetanide than furosemide was absorbed. The elimination half-life of furosemide was approximat …
175 results