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29 results

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Page 1
The ion channel TRPM8 is a direct target of the immunosuppressant rapamycin in primary sensory neurons.
Arcas JM, Oudaha K, González A, Fernández-Trillo J, Peralta FA, Castro-Marsal J, Poyraz S, Taberner F, Sala S, de la Peña E, Gomis A, Viana F. Arcas JM, et al. Br J Pharmacol. 2024 Sep;181(17):3192-3214. doi: 10.1111/bph.16402. Epub 2024 May 13. Br J Pharmacol. 2024. PMID: 38741464 Free article.
We hypothesized that rapamycin may also have agonist activity on TRPM8 channels. EXPERIMENTAL APPROACH: Using calcium imaging and electrophysiology in transfected HEK293 cells and wildtype or Trpm8 KO mouse DRG neurons, we characterized rapamycin's effects on TRPM8 channel …
We hypothesized that rapamycin may also have agonist activity on TRPM8 channels. EXPERIMENTAL APPROACH: Using calcium imaging and ele …
Competitive CatSper Activators of Progesterone from Rhynchosia volubilis.
Xiang J, Kang H, Li HG, Shi YL, Zhang YL, Ruan CL, Liu LH, Gao HQ, Luo T, Hu GS, Zhu WL, Jia JM, Chen JC, Fang JB. Xiang J, et al. Planta Med. 2022 Sep;88(11):881-890. doi: 10.1055/a-1542-0151. Epub 2021 Aug 6. Planta Med. 2022. PMID: 34359084 Free PMC article.
In human sperm, it was reported that the cation channel of sperm, an indispensable cation channel for the fertilization process, could be regulated by various steroid-like compounds in plants. Interestingly, these nonphysiological ligands would also disturb the acti …
In human sperm, it was reported that the cation channel of sperm, an indispensable cation channel for the fertilization proces …
Pathophysiology of red cell volume.
Browning JA, Ellory JC, Gibson JS. Browning JA, et al. Contrib Nephrol. 2006;152:241-268. doi: 10.1159/000096327. Contrib Nephrol. 2006. PMID: 17065816 Review.
Finally, a number of red cell stomatocytoses have been described where alterations to erythrocyte volume are the result of increased membrane cation permeability, in particular to Na(+) and K(+). The emerging significance of non-selective cation pathways is common t …
Finally, a number of red cell stomatocytoses have been described where alterations to erythrocyte volume are the result of increased membran …
Ocular Pharmacology and Toxicology of TRPV1 Antagonist SAF312 (Libvatrep).
Mogi M, Mendonza AE, Chastain J, Demirs JT, Medley QG, Zhang Q, Papillon JPN, Yang J, Gao Y, Xu Y, Stasi K. Mogi M, et al. Transl Vis Sci Technol. 2023 Sep 1;12(9):5. doi: 10.1167/tvst.12.9.5. Transl Vis Sci Technol. 2023. PMID: 37672251 Free PMC article.
METHODS: TRPV1 expression in human ocular tissues was evaluated with immunohistochemistry. Inhibition of calcium influx in Chinese hamster ovary (CHO) cells expressing human TRPV1 (hTRPV1) and selectivity of SAF312 were assessed by a fluorescent imaging plate reader assay. …
METHODS: TRPV1 expression in human ocular tissues was evaluated with immunohistochemistry. Inhibition of calcium influx in Chinese ha …
Cation type specific cell remodeling regulates attachment strength.
Fuhrmann A, Li J, Chien S, Engler AJ. Fuhrmann A, et al. PLoS One. 2014 Jul 11;9(7):e102424. doi: 10.1371/journal.pone.0102424. eCollection 2014. PLoS One. 2014. PMID: 25014042 Free PMC article.
Single-molecule experiments indicate that integrin affinity is cation-type-dependent, but in spread cells integrins are engaged in complex focal adhesions (FAs), which can also regulate affinity. To better understand cation-type-dependent adhesion in fully spread ce …
Single-molecule experiments indicate that integrin affinity is cation-type-dependent, but in spread cells integrins are engaged in co …
Lipid modulation of calcium flux through CaV2.3 regulates acrosome exocytosis and fertilization.
Cohen R, Buttke DE, Asano A, Mukai C, Nelson JL, Ren D, Miller RJ, Cohen-Kutner M, Atlas D, Travis AJ. Cohen R, et al. Dev Cell. 2014 Feb 10;28(3):310-21. doi: 10.1016/j.devcel.2014.01.005. Dev Cell. 2014. PMID: 24525187 Free PMC article.
In early development, sterol efflux and the ganglioside GM1 regulate sperm acrosome exocytosis (AE) and fertilization competence through unknown mechanisms. Here, we show that sterol efflux and focal enrichment of GM1 trigger Ca(2+) influx necessary for AE through C …
In early development, sterol efflux and the ganglioside GM1 regulate sperm acrosome exocytosis (AE) and fertilization competence thro …
Endocardial TRPC-6 Channels Act as Atrial Mechanosensors and Load-Dependent Modulators of Endocardial/Myocardial Cross-Talk.
Nikolova-Krstevski V, Wagner S, Yu ZY, Cox CD, Cvetkovska J, Hill AP, Huttner IG, Benson V, Werdich AA, MacRae C, Feneley MP, Friedrich O, Martinac B, Fatkin D. Nikolova-Krstevski V, et al. JACC Basic Transl Sci. 2017 Oct 30;2(5):575-590. doi: 10.1016/j.jacbts.2017.05.006. eCollection 2017 Oct. JACC Basic Transl Sci. 2017. PMID: 30062171 Free PMC article.
This study showed that mechanical stretch altered the localization, protein levels, and function of the cation-selective transient receptor potential channel (TRPC)-6 in atrial endocardial cells in humans, pigs, and mice. In endocardial/myocardial cross-talk studies, addit …
This study showed that mechanical stretch altered the localization, protein levels, and function of the cation-selective transient re …
Global cytoskeletal control of mechanotransduction in kidney epithelial cells.
Alenghat FJ, Nauli SM, Kolb R, Zhou J, Ingber DE. Alenghat FJ, et al. Exp Cell Res. 2004 Nov 15;301(1):23-30. doi: 10.1016/j.yexcr.2004.08.003. Exp Cell Res. 2004. PMID: 15501441
Disrupting cytoplasmic microfilaments or microtubules in these cells eliminated fluid shear stress-induced increase of intracellular calcium. Altering the cytoskeletal force balance by inhibiting actomyosin-based tension generation (using 2,3-butanedione monoxime), interfe …
Disrupting cytoplasmic microfilaments or microtubules in these cells eliminated fluid shear stress-induced increase of intracellular calc …
Two novel 2-aminoethyl diphenylborinate (2-APB) analogues differentially activate and inhibit store-operated Ca(2+) entry via STIM proteins.
Goto J, Suzuki AZ, Ozaki S, Matsumoto N, Nakamura T, Ebisui E, Fleig A, Penner R, Mikoshiba K. Goto J, et al. Cell Calcium. 2010 Jan;47(1):1-10. doi: 10.1016/j.ceca.2009.10.004. Epub 2009 Nov 27. Cell Calcium. 2010. PMID: 19945161 Free PMC article.
Store-operated calcium entry (SOCE) or calcium release-activated calcium current (I(CRAC)) is a critical pathway to replenish intracellular calcium stores, and plays indispensable roles in cellular functions such as antigen-induced T lymphocyte activat …
Store-operated calcium entry (SOCE) or calcium release-activated calcium current (I(CRAC)) is a critical pathway to rep …
Carbonic anhydrase inhibition prevents and reverts cardiomyocyte hypertrophy.
Alvarez BV, Johnson DE, Sowah D, Soliman D, Light PE, Xia Y, Karmazyn M, Casey JR. Alvarez BV, et al. J Physiol. 2007 Feb 15;579(Pt 1):127-45. doi: 10.1113/jphysiol.2006.123638. Epub 2006 Nov 23. J Physiol. 2007. PMID: 17124262 Free PMC article.
In addition, ETZ inhibited transport activity of NHE1 and the AE isoform, AE3, with respective EC50 values of 1.2 +/- 0.3 microm and 2.7 +/- 0.3 microm. ...
In addition, ETZ inhibited transport activity of NHE1 and the AE isoform, AE3, with respective EC50 values of 1.2 +/- 0.3 microm and …
29 results