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92 results

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Controlled Activation of TRPV1 Channels on Microglia to Boost Their Autophagy for Clearance of Alpha-Synuclein and Enhance Therapy of Parkinson's Disease.
Yuan J, Liu H, Zhang H, Wang T, Zheng Q, Li Z. Yuan J, et al. Adv Mater. 2022 Mar;34(11):e2108435. doi: 10.1002/adma.202108435. Epub 2022 Feb 6. Adv Mater. 2022. PMID: 35023596
Parkinson's disease (PD) is characterized with accumulation of Lewy bodies with a major component of fibrillar alpha-synuclein (alpha-syn). ...The enzyme tyrosine hydroxylase, ionized calcium binding adapter protein 1, glial fibrillary acidic protein, and pSer129-al …
Parkinson's disease (PD) is characterized with accumulation of Lewy bodies with a major component of fibrillar alpha-synuclein (alpha …
LRRK2 is required for CD38-mediated NAADP-Ca2+ signaling and the downstream activation of TFEB (transcription factor EB) in immune cells.
Nabar NR, Heijjer CN, Shi CS, Hwang IY, Ganesan S, Karlsson MCI, Kehrl JH. Nabar NR, et al. Autophagy. 2022 Jan;18(1):204-222. doi: 10.1080/15548627.2021.1954779. Epub 2021 Jul 27. Autophagy. 2022. PMID: 34313548 Free PMC article.
CD38 is a cell surface receptor capable of generating calcium-mobilizing second messengers. It has been implicated in host defense and cancer biology, but signaling mechanisms downstream of CD38 remain unclear. ...In overexpression models, the pathogenic LRRK2(G2019S) muta …
CD38 is a cell surface receptor capable of generating calcium-mobilizing second messengers. It has been implicated in host defense an …
TRPC Channels and Parkinson's Disease.
Sukumaran P, Sun Y, Schaar A, Selvaraj S, Singh BB. Sukumaran P, et al. Adv Exp Med Biol. 2017;976:85-94. doi: 10.1007/978-94-024-1088-4_8. Adv Exp Med Biol. 2017. PMID: 28508315 Free PMC article. Review.
Importantly, though disturbances in Ca(2+) homeostasis have been implicated in Parkinson's disease and other neuronal diseases, the identity of the calcium channel remains elusive. Members of the transient receptor potential canonical (TRPC) channel family have been identi …
Importantly, though disturbances in Ca(2+) homeostasis have been implicated in Parkinson's disease and other neuronal diseases, the identity …
Transient Receptor Potential Cation Channels and Calcium Dyshomeostasis in a Mouse Model Relevant to Malignant Hyperthermia.
Rafael Lopez J, Kaura V, Hopkins P, Liu X, Uryach A, Adams J, Allen PD. Rafael Lopez J, et al. Anesthesiology. 2020 Aug;133(2):364-376. doi: 10.1097/ALN.0000000000003387. Anesthesiology. 2020. PMID: 32665491 Free PMC article.
These increases were inhibited both by simply removing extracellular Ca and by exposure to either a nonspecific (gadolinium) or a newly available, more specific pharmacologic agent (SAR7334) to block TRPC6- and TRPC3-mediated cation influx into cells. Furthermore, local pr …
These increases were inhibited both by simply removing extracellular Ca and by exposure to either a nonspecific (gadolinium) or a newly avai …
TRPMLs and TPCs: Targets for lysosomal storage and neurodegenerative disease therapy?
Krogsaeter E, Rosato AS, Grimm C. Krogsaeter E, et al. Cell Calcium. 2022 May;103:102553. doi: 10.1016/j.ceca.2022.102553. Epub 2022 Feb 5. Cell Calcium. 2022. PMID: 35144097
Alzheimer's disease (AD) is the most prevalent type of ND or dementia, followed by Parkinson's disease (PD), multiple sclerosis, amyotrophic lateral sclerosis, and Huntington's disease. Progressive neurological dysfunction and regional neuronal loss constitute the common c …
Alzheimer's disease (AD) is the most prevalent type of ND or dementia, followed by Parkinson's disease (PD), multiple sclerosis, amyo …
TRPM2 as a conserved gatekeeper determines the vulnerability of DA neurons by mediating ROS sensing and calcium dyshomeostasis.
Ye P, Fang Q, Hu X, Zou W, Huang M, Ke M, Li Y, Liu M, Cai X, Zhang C, Hua N, Al-Sheikh U, Liu X, Yu P, Jiang P, Pan PY, Luo J, Jiang LH, Xu S, Fang EF, Su H, Kang L, Yang W. Ye P, et al. Prog Neurobiol. 2023 Dec;231:102530. doi: 10.1016/j.pneurobio.2023.102530. Epub 2023 Sep 20. Prog Neurobiol. 2023. PMID: 37739206 Free article.
Here we report that the transient receptor potential melastatin 2 (TRPM2) channel is preferentially expressed in vulnerable DA neuronal subgroups, which correlates positively with aging in Parkinson's Disease (PD) patients. Overexpression of human TRPM2 in the DA neurons o …
Here we report that the transient receptor potential melastatin 2 (TRPM2) channel is preferentially expressed in vulnerable DA neuronal subg …
TRPM7 and its role in neurodegenerative diseases.
Sun Y, Sukumaran P, Schaar A, Singh BB. Sun Y, et al. Channels (Austin). 2015;9(5):253-61. doi: 10.1080/19336950.2015.1075675. Epub 2015 Jul 28. Channels (Austin). 2015. PMID: 26218331 Free PMC article. Review.
Calcium (Ca(2+)) and magnesium (Mg(2+)) ions have been shown to play an important role in regulating various neuronal functions. ...Importantly, the discrepancy in TRPM7 channel function and expression leads to various neuronal diseases such as Alzheimer disease (AD) and P …
Calcium (Ca(2+)) and magnesium (Mg(2+)) ions have been shown to play an important role in regulating various neuronal functions. ...I …
TRP channels: Role in neurodegenerative diseases and therapeutic targets.
Rather MA, Khan A, Wang L, Jahan S, Rehman MU, Makeen HA, Mohan S. Rather MA, et al. Heliyon. 2023 Jun 2;9(6):e16910. doi: 10.1016/j.heliyon.2023.e16910. eCollection 2023 Jun. Heliyon. 2023. PMID: 37332910 Free PMC article. Review.
TRP (Transient receptor potential) channels are integral membrane proteins consisting of a superfamily of cation channels that allow permeability of both monovalent and divalent cations. TRP channels are subdivided into six subfamilies: TRPC, TRPV, TRPM, TRPP, TRPML, and T …
TRP (Transient receptor potential) channels are integral membrane proteins consisting of a superfamily of cation channels that allow …
Microglial Activation and Inflammatory Responses in Parkinson's Disease Models Are Attenuated by TRPM2 Depletion.
Ferreira AFF, Feng ZP, Sun HS, Britto LRG. Ferreira AFF, et al. Glia. 2025 Oct;73(10):2035-2056. doi: 10.1002/glia.70055. Epub 2025 Jul 15. Glia. 2025. PMID: 40665621 Free PMC article.
However, the role of TRPM2 in inflammation and microglial activation in the context of PD remains unclear. Here, we combined both in vivo and in vitro PD models to investigate that question. ...To better understand TRPM2 involvement in PD pathology, we select …
However, the role of TRPM2 in inflammation and microglial activation in the context of PD remains unclear. Here, we combined both in …
The Role of Voltage-Dependent Anion Channel in Mitochondrial Dysfunction and Human Disease.
Varughese JT, Buchanan SK, Pitt AS. Varughese JT, et al. Cells. 2021 Jul 9;10(7):1737. doi: 10.3390/cells10071737. Cells. 2021. PMID: 34359907 Free PMC article. Review.
VDAC has two conductance states: an open anion selective state, and a closed and slightly cation-selective state. VDAC conductance states play major roles in regulating permeability of ATP/ADP, regulation of calcium homeostasis, calcium flux within ER-mitocho …
VDAC has two conductance states: an open anion selective state, and a closed and slightly cation-selective state. VDAC conductance st …
92 results