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LRRK2 is required for CD38-mediated NAADP-Ca2+ signaling and the downstream activation of TFEB (transcription factor EB) in immune cells.
Nabar NR, Heijjer CN, Shi CS, Hwang IY, Ganesan S, Karlsson MCI, Kehrl JH. Nabar NR, et al. Autophagy. 2022 Jan;18(1):204-222. doi: 10.1080/15548627.2021.1954779. Epub 2021 Jul 27. Autophagy. 2022. PMID: 34313548 Free PMC article.
CD38 is a cell surface receptor capable of generating calcium-mobilizing second messengers. It has been implicated in host defense and cancer biology, but signaling mechanisms downstream of CD38 remain unclear. ...In overexpression models, the pathogenic LRRK2(G2019S) muta …
CD38 is a cell surface receptor capable of generating calcium-mobilizing second messengers. It has been implicated in host defense an …
Controlled Activation of TRPV1 Channels on Microglia to Boost Their Autophagy for Clearance of Alpha-Synuclein and Enhance Therapy of Parkinson's Disease.
Yuan J, Liu H, Zhang H, Wang T, Zheng Q, Li Z. Yuan J, et al. Adv Mater. 2022 Mar;34(11):e2108435. doi: 10.1002/adma.202108435. Epub 2022 Feb 6. Adv Mater. 2022. PMID: 35023596
Parkinson's disease (PD) is characterized with accumulation of Lewy bodies with a major component of fibrillar alpha-synuclein (alpha-syn). ...The enzyme tyrosine hydroxylase, ionized calcium binding adapter protein 1, glial fibrillary acidic protein, and pSer129-al …
Parkinson's disease (PD) is characterized with accumulation of Lewy bodies with a major component of fibrillar alpha-synuclein (alpha …
TRPMLs and TPCs: Targets for lysosomal storage and neurodegenerative disease therapy?
Krogsaeter E, Rosato AS, Grimm C. Krogsaeter E, et al. Cell Calcium. 2022 May;103:102553. doi: 10.1016/j.ceca.2022.102553. Epub 2022 Feb 5. Cell Calcium. 2022. PMID: 35144097
Alzheimer's disease (AD) is the most prevalent type of ND or dementia, followed by Parkinson's disease (PD), multiple sclerosis, amyotrophic lateral sclerosis, and Huntington's disease. Progressive neurological dysfunction and regional neuronal loss constitute the common c …
Alzheimer's disease (AD) is the most prevalent type of ND or dementia, followed by Parkinson's disease (PD), multiple sclerosis, amyo …
TRPC Channels and Parkinson's Disease.
Sukumaran P, Sun Y, Schaar A, Selvaraj S, Singh BB. Sukumaran P, et al. Adv Exp Med Biol. 2017;976:85-94. doi: 10.1007/978-94-024-1088-4_8. Adv Exp Med Biol. 2017. PMID: 28508315 Free PMC article. Review.
Importantly, though disturbances in Ca(2+) homeostasis have been implicated in Parkinson's disease and other neuronal diseases, the identity of the calcium channel remains elusive. Members of the transient receptor potential canonical (TRPC) channel family have been identi …
Importantly, though disturbances in Ca(2+) homeostasis have been implicated in Parkinson's disease and other neuronal diseases, the identity …
TRPM2 as a conserved gatekeeper determines the vulnerability of DA neurons by mediating ROS sensing and calcium dyshomeostasis.
Ye P, Fang Q, Hu X, Zou W, Huang M, Ke M, Li Y, Liu M, Cai X, Zhang C, Hua N, Al-Sheikh U, Liu X, Yu P, Jiang P, Pan PY, Luo J, Jiang LH, Xu S, Fang EF, Su H, Kang L, Yang W. Ye P, et al. Prog Neurobiol. 2023 Dec;231:102530. doi: 10.1016/j.pneurobio.2023.102530. Epub 2023 Sep 20. Prog Neurobiol. 2023. PMID: 37739206 Free article.
Here we report that the transient receptor potential melastatin 2 (TRPM2) channel is preferentially expressed in vulnerable DA neuronal subgroups, which correlates positively with aging in Parkinson's Disease (PD) patients. Overexpression of human TRPM2 in the DA neurons o …
Here we report that the transient receptor potential melastatin 2 (TRPM2) channel is preferentially expressed in vulnerable DA neuronal subg …
Transient Receptor Potential Cation Channels and Calcium Dyshomeostasis in a Mouse Model Relevant to Malignant Hyperthermia.
Rafael Lopez J, Kaura V, Hopkins P, Liu X, Uryach A, Adams J, Allen PD. Rafael Lopez J, et al. Anesthesiology. 2020 Aug;133(2):364-376. doi: 10.1097/ALN.0000000000003387. Anesthesiology. 2020. PMID: 32665491 Free PMC article.
These increases were inhibited both by simply removing extracellular Ca and by exposure to either a nonspecific (gadolinium) or a newly available, more specific pharmacologic agent (SAR7334) to block TRPC6- and TRPC3-mediated cation influx into cells. Furthermore, local pr …
These increases were inhibited both by simply removing extracellular Ca and by exposure to either a nonspecific (gadolinium) or a newly avai …
Microglial Activation and Inflammatory Responses in Parkinson's Disease Models Are Attenuated by TRPM2 Depletion.
Ferreira AFF, Feng ZP, Sun HS, Britto LRG. Ferreira AFF, et al. Glia. 2025 Oct;73(10):2035-2056. doi: 10.1002/glia.70055. Epub 2025 Jul 15. Glia. 2025. PMID: 40665621 Free PMC article.
However, the role of TRPM2 in inflammation and microglial activation in the context of PD remains unclear. Here, we combined both in vivo and in vitro PD models to investigate that question. ...To better understand TRPM2 involvement in PD pathology, we select …
However, the role of TRPM2 in inflammation and microglial activation in the context of PD remains unclear. Here, we combined both in …
The role of TRPV4 in ferroptosis in MPP+/MPTP-induced Parkinson's disease models.
Ma Q, Wu J, Li H, Yin R, Yang W, Luo J, Bai Y, Liu N. Ma Q, et al. Tissue Cell. 2025 Oct;96:103019. doi: 10.1016/j.tice.2025.103019. Epub 2025 Jun 16. Tissue Cell. 2025. PMID: 40554139
BACKGROUND: Transient receptor potential vanilloid 4 (TRPV4) is a nonselective calcium-permeable cation channel. Our previous study revealed that TRPV4 mediates endoplasmic reticulum (ER) stress and inflammation, leading to the loss of dopamine neurons in 1-methyl-4 …
BACKGROUND: Transient receptor potential vanilloid 4 (TRPV4) is a nonselective calcium-permeable cation channel. Our previous …
Deletion of the Transient Receptor Potential Melastatin 2 Gene Mitigates the 6-Hydroxydopamine-Induced Parkinson's Disease-Like Pathology.
Ferreira AFF, Ulrich H, Mori Y, Feng ZP, Sun HS, Britto LR. Ferreira AFF, et al. Mol Neurobiol. 2025 Apr;62(4):5333-5346. doi: 10.1007/s12035-024-04611-9. Epub 2024 Nov 14. Mol Neurobiol. 2025. PMID: 39541072
Pharmacological inhibition of the transient receptor potential melastatin 2 (TRPM2), an oxidative stress-activated calcium channel, was previously reported to be protective in Parkinson's disease (PD). ...These findings suggest that TRPM2 is involved in the PD …
Pharmacological inhibition of the transient receptor potential melastatin 2 (TRPM2), an oxidative stress-activated calcium channel, w …
TRPM7 and its role in neurodegenerative diseases.
Sun Y, Sukumaran P, Schaar A, Singh BB. Sun Y, et al. Channels (Austin). 2015;9(5):253-61. doi: 10.1080/19336950.2015.1075675. Epub 2015 Jul 28. Channels (Austin). 2015. PMID: 26218331 Free PMC article. Review.
Calcium (Ca(2+)) and magnesium (Mg(2+)) ions have been shown to play an important role in regulating various neuronal functions. ...Importantly, the discrepancy in TRPM7 channel function and expression leads to various neuronal diseases such as Alzheimer disease (AD) and P …
Calcium (Ca(2+)) and magnesium (Mg(2+)) ions have been shown to play an important role in regulating various neuronal functions. ...I …
93 results