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Page 1
The Physiopathologic Roles of Calcium Signaling in Podocytes.
Tu YC, Shu HP, Sun LL, Liao QQ, Feng L, Ren M, Yao LJ. Tu YC, et al. Front Biosci (Landmark Ed). 2023 Oct 18;28(10):240. doi: 10.31083/j.fbl2810240. Front Biosci (Landmark Ed). 2023. PMID: 37919067 Free article. Review.
Calcium (Ca2+) plays a critical role in podocyte function. The Ca2+-sensitive receptors on the cell surface can sense changes in Ca2+ concentration, and Ca2+ flow into podocytes, after activation of Ca2+ channels (such as transient receptor potential canonical (TRPC) chann …
Calcium (Ca2+) plays a critical role in podocyte function. The Ca2+-sensitive receptors on the cell surface can sense changes in Ca2+ …
Loss of lung microvascular endothelial Piezo2 expression impairs NO synthesis, induces EndMT, and is associated with pulmonary hypertension.
Tian S, Cai Z, Sen P, van Uden D, van de Kamp E, Thuillet R, Tu L, Guignabert C, Boomars K, Van der Heiden K, Brandt MM, Merkus D. Tian S, et al. Am J Physiol Heart Circ Physiol. 2022 Nov 1;323(5):H958-H974. doi: 10.1152/ajpheart.00220.2022. Epub 2022 Sep 23. Am J Physiol Heart Circ Physiol. 2022. PMID: 36149769 Free article.
Mechanical forces are translated into biochemical stimuli by mechanotransduction channels, such as the mechanically activated cation channel Piezo2. Lung Piezo2 expression has recently been shown to be restricted to endothelial cells. ...Mechanistically, Piezo2 is required …
Mechanical forces are translated into biochemical stimuli by mechanotransduction channels, such as the mechanically activated cation …
Structure and function of the human mitochondrial MRS2 channel.
He Z, Tu YC, Tsai CW, Mount J, Zhang J, Tsai MF, Yuan P. He Z, et al. Nat Struct Mol Biol. 2025 Mar;32(3):459-468. doi: 10.1038/s41594-024-01420-5. Epub 2024 Nov 28. Nat Struct Mol Biol. 2025. PMID: 39609651 Free PMC article.
Moreover, a conserved arginine ring within the pore of MRS2 functions to restrict cation movements, thus preventing the channel from collapsing the proton motive force that drives mitochondrial adenosine triphosphate synthesis. ...
Moreover, a conserved arginine ring within the pore of MRS2 functions to restrict cation movements, thus preventing the channel from …
Osmosensor TMEM63B facilitates insulin secretion in pancreatic β-cells.
Tu JJ, Ye C, Teng XY, Zang YY, Sun XY, Chen S, Chen J, Shi YS. Tu JJ, et al. Sci China Life Sci. 2025 Jun;68(6):1714-1726. doi: 10.1007/s11427-024-2833-3. Epub 2025 Feb 20. Sci China Life Sci. 2025. PMID: 39985646
In this study, we found that TMEM63B is a stretch-activated cation channel (SAC) crucial for regulating insulin secretion in response to elevated glucose levels. ...
In this study, we found that TMEM63B is a stretch-activated cation channel (SAC) crucial for regulating insulin secretion in response …
Mechanism of Calcium Permeation in a Glutamate Receptor Ion Channel.
Schackert FK, Biedermann J, Abdolvand S, Minniberger S, Song C, Plested AJR, Carloni P, Sun H. Schackert FK, et al. J Chem Inf Model. 2023 Feb 27;63(4):1293-1300. doi: 10.1021/acs.jcim.2c01494. Epub 2023 Feb 9. J Chem Inf Model. 2023. PMID: 36758214 Free PMC article.
The alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) are neurotransmitter-activated cation channels ubiquitously expressed in vertebrate brains. The regulation of calcium flux through the channel pore by RNA-editing is linked to synaptic p …
The alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) are neurotransmitter-activated cation channels ubiqui …
Selectivity mechanism of magnesium and calcium in cation-binding pocket structures of phosphotyrosine.
Tu Y, Liu H, Shi G, Zhang F, Su T, Wu Y, Sun J, Zhang L, Zhang S, Fang H. Tu Y, et al. Phys Rev E. 2020 Feb;101(2-1):022410. doi: 10.1103/PhysRevE.101.022410. Phys Rev E. 2020. PMID: 32168574
Magnesium (Mg^{2+}) and calcium (Ca^{2+}) are of essential importance in biological activity, but the molecular understanding of their selectivity is still lacking. ...The key for the selectivity is attributed to the cation-pi interactions between the hydrated catio …
Magnesium (Mg^{2+}) and calcium (Ca^{2+}) are of essential importance in biological activity, but the molecular understanding of thei …
KFP-1, a Novel Calcium-Binding Peptide Isolated from Kefir, Promotes Calcium Influx Through TRPV6 Channels.
Chang GR, Tu MY, Chen YH, Chang KY, Chen CF, Lai JC, Tung YT, Chen HL, Fan HC, Chen CM. Chang GR, et al. Mol Nutr Food Res. 2021 Nov;65(22):e2100182. doi: 10.1002/mnfr.202100182. Epub 2021 Oct 19. Mol Nutr Food Res. 2021. PMID: 34477300
TRPV6, but not L-type voltage-gated calcium channels, is associated with the calcium influx induced by KFP-1. An in vitro calcium binding assay indicates that the full-length KFP-1 peptide has a higher calcium-binding capacity than the two truncated KF …
TRPV6, but not L-type voltage-gated calcium channels, is associated with the calcium influx induced by KFP-1. An in vitro c …
58 results