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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1990 3
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1992 7
1993 15
1994 2
1995 2
1996 5
1997 6
1998 6
1999 16
2000 7
2001 14
2002 8
2003 12
2004 3
2005 4
2006 12
2007 7
2008 11
2009 7
2010 2
2011 2
2012 2
2013 4
2014 9
2015 8
2016 6
2017 5
2018 5
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2020 3
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2023 5
2024 3

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208 results

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Page 1
Effect of Cefepime/Enmetazobactam vs Piperacillin/Tazobactam on Clinical Cure and Microbiological Eradication in Patients With Complicated Urinary Tract Infection or Acute Pyelonephritis: A Randomized Clinical Trial.
Kaye KS, Belley A, Barth P, Lahlou O, Knechtle P, Motta P, Velicitat P. Kaye KS, et al. JAMA. 2022 Oct 4;328(13):1304-1314. doi: 10.1001/jama.2022.17034. JAMA. 2022. PMID: 36194218 Free PMC article. Clinical Trial.
IMPORTANCE: Cefepime/enmetazobactam is a novel beta-lactam/beta-lactamase inhibitor combination and a potential empirical therapy for resistant gram-negative infections. ...Further research is needed to determine the potential role for cefepime/enmetazobactam in the …
IMPORTANCE: Cefepime/enmetazobactam is a novel beta-lactam/beta-lactamase inhibitor combination and a potential empirical therapy for …
Cefepime-Taniborbactam in Complicated Urinary Tract Infection.
Wagenlehner FM, Gasink LB, McGovern PC, Moeck G, McLeroth P, Dorr M, Dane A, Henkel T; CERTAIN-1 Study Team. Wagenlehner FM, et al. N Engl J Med. 2024 Feb 15;390(7):611-622. doi: 10.1056/NEJMoa2304748. N Engl J Med. 2024. PMID: 38354140 Clinical Trial.
Composite success occurred in 207 of 293 patients (70.6%) in the cefepime-taniborbactam group and in 83 of 143 patients (58.0%) in the meropenem group. ...Differences in treatment response were sustained at late follow-up (trial days 28 to 35), when cefepime-tanibor …
Composite success occurred in 207 of 293 patients (70.6%) in the cefepime-taniborbactam group and in 83 of 143 patients (58.0%) in th …
Optimisation of empirical antimicrobial therapy in patients with haematological malignancies and febrile neutropenia (How Long study): an open-label, randomised, controlled phase 4 trial.
Aguilar-Guisado M, Espigado I, Martín-Peña A, Gudiol C, Royo-Cebrecos C, Falantes J, Vázquez-López L, Montero MI, Rosso-Fernández C, de la Luz Martino M, Parody R, González-Campos J, Garzón-López S, Calderón-Cabrera C, Barba P, Rodríguez N, Rovira M, Montero-Mateos E, Carratalá J, Pérez-Simón JA, Cisneros JM. Aguilar-Guisado M, et al. Lancet Haematol. 2017 Dec;4(12):e573-e583. doi: 10.1016/S2352-3026(17)30211-9. Epub 2017 Nov 15. Lancet Haematol. 2017. PMID: 29153975 Clinical Trial.
EAT based on an antipseudomonal beta-lactam drug as monotherapy (ceftazidime or cefepime, meropenem or imipenem, or piperacillin-tazobactam) or as combination therapy (with an aminoglycoside, fluoroquinolone, or glycopeptide) was started according to local protocols and fo …
EAT based on an antipseudomonal beta-lactam drug as monotherapy (ceftazidime or cefepime, meropenem or imipenem, or piperacillin-tazo …
Randomized controlled trial of piperacillin-tazobactam, cefepime and ertapenem for the treatment of urinary tract infection caused by extended-spectrum beta-lactamase-producing Escherichia coli.
Seo YB, Lee J, Kim YK, Lee SS, Lee JA, Kim HY, Uh Y, Kim HS, Song W. Seo YB, et al. BMC Infect Dis. 2017 Jun 7;17(1):404. doi: 10.1186/s12879-017-2502-x. BMC Infect Dis. 2017. PMID: 28592240 Free PMC article. Clinical Trial.
After the recruitment of six participants, assignment to the cefepime treatment group was stopped because of an unexpectedly high treatment failure rate. ...The clinical and microbiological response to PTZ treatment was estimated to be 94% and was similar to the response t …
After the recruitment of six participants, assignment to the cefepime treatment group was stopped because of an unexpectedly high tre …
In complicated UTI or pyelonephritis, cefepime-enmetazobactam increased success vs. piperacillin-tazobactam at 14 d.
Maki DG. Maki DG. Ann Intern Med. 2023 Feb;176(2):JC21. doi: 10.7326/J22-0114. Epub 2023 Feb 7. Ann Intern Med. 2023. PMID: 36745895 Clinical Trial.
Kaye KS, Belley A, Barth P, et al. Effect of cefepime/enmetazobactam vs piperacillin/tazobactam on clinical cure and microbiological eradication in patients with complicated urinary tract infection or acute pyelonephritis: a randomized clinical trial. ...
Kaye KS, Belley A, Barth P, et al. Effect of cefepime/enmetazobactam vs piperacillin/tazobactam on clinical cure and microbiological …
A Randomized Clinical Trial of Bayesian-Guided Beta-Lactam Infusion Strategy and Associated Bacterial Resistance and Clinical Outcomes in Patients With Severe Pneumonia.
Maranchick NF, Trillo-Alvarez C, Kariyawasam V, Venugopalan V, Kwara A, Rand K, Peloquin CA, Alshaer MH. Maranchick NF, et al. Ther Drug Monit. 2024 Feb 1;46(1):95-101. doi: 10.1097/FTD.0000000000001144. Epub 2023 Nov 15. Ther Drug Monit. 2024. PMID: 38018847 Free PMC article. Clinical Trial.
The objective of this study was to evaluate the effect of beta-lactam infusion on the emergence of bacterial resistance in patients with severe pneumonia in the intensive care unit. METHODS: Adult intensive care patients receiving cefepime, meropenem, or piperacillin-tazob …
The objective of this study was to evaluate the effect of beta-lactam infusion on the emergence of bacterial resistance in patients with sev …
Single-Center Investigation of the Pharmacokinetics of WCK 4282 (Cefepime-Tazobactam Combination) in Renal Impairment.
Preston RA, Mamikonyan G, Mastim M, Garg D, Kemper CJ, Xu A, Yeole R, Chavan R, Friedland HD, Bhatia A. Preston RA, et al. Antimicrob Agents Chemother. 2019 Sep 23;63(10):e00873-19. doi: 10.1128/AAC.00873-19. Print 2019 Oct. Antimicrob Agents Chemother. 2019. PMID: 31332068 Free PMC article. Clinical Trial.
WCK 4282 is a combination product of cefepime (FEP) and tazobactam (TAZ) in a 1:1 ratio currently under development for the treatment of multidrug-resistant Gram-negative bacterial infections. ...
WCK 4282 is a combination product of cefepime (FEP) and tazobactam (TAZ) in a 1:1 ratio currently under development for the treatment …
Clinical efficacy and safety of cefepime in febrile neutropenic patients with lung cancer.
Fujita M, Ouchi H, Inoue Y, Inoshima I, Ohshima T, Yoshimura C, Wataya H, Kawasaki M, Tokunaga S, Nakanishi Y; Lung Oncology Group in Kyushu (LOGIK). Fujita M, et al. J Infect Chemother. 2010 Apr;16(2):113-7. doi: 10.1007/s10156-010-0030-3. Epub 2010 Feb 4. J Infect Chemother. 2010. PMID: 20130951 Clinical Trial.
The objective of this study was to determine the efficacy and safety of cefepime for FN in lung cancer patients. Cefepime (2 g x 2/day) was administered to patients with FN after treatment for lung cancer. ...Empiric monotherapy using cefepime is a recommende …
The objective of this study was to determine the efficacy and safety of cefepime for FN in lung cancer patients. Cefepime (2 g …
Cefepime. Pharmacokinetics and clinical response in patients with cystic fibrosis.
Arguedas AG, Stutman HR, Zaleska M, Knupp CA, Marks MI, Nussbaum E. Arguedas AG, et al. Am J Dis Child. 1992 Jul;146(7):797-802. doi: 10.1001/archpedi.1992.02160190029013. Am J Dis Child. 1992. PMID: 1496945 Clinical Trial.
OBJECTIVE: To measure first-dose and steady-state plasma, urine, and sputum concentrations of cefepime and make preliminary assessments of the clinical efficacy of cefepime in patients with cystic fibrosis. ...PARTICIPANTS: Twelve patients, aged 4 to 41 years, with …
OBJECTIVE: To measure first-dose and steady-state plasma, urine, and sputum concentrations of cefepime and make preliminary assessmen …
208 results