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Efficacy and Safety of Clidinium/Chlordiazepoxide as an Add-on Therapy in Functional Dyspepsia: A Randomized, Controlled, Trial.
Puasripun S, Thinrungroj N, Pinyopornpanish K, Kijdamrongthum P, Leerapun A, Chitapanarux T, Thongsawat S, Praisontarangkul OA. Puasripun S, et al. J Neurogastroenterol Motil. 2020 Apr 30;26(2):259-266. doi: 10.5056/jnm19186. J Neurogastroenterol Motil. 2020. PMID: 32235033 Free PMC article.
The clidinium/chlordiazepoxide group also showed significant improvement in overall quality of life over placebo. However, the clidinium/chlordiazepoxide group had more frequent drowsiness than the placebo group (30.27% vs 6.52%, P = 0.034). ...
The clidinium/chlordiazepoxide group also showed significant improvement in overall quality of life over placebo. However, the …
Simultaneous Determination of Clidinium Bromide and Chlordiazepoxide in Combined Dosage Forms by High-Performance Liquid Chromatography.
Ashour S, Kattan N. Ashour S, et al. J Pharm (Cairo). 2013;2013:417682. doi: 10.1155/2013/417682. Epub 2013 Feb 24. J Pharm (Cairo). 2013. PMID: 26555978 Free PMC article.
A sensitive and precise RP-HPLC method has been developed for the simultaneous estimation of clidinium bromide (CDB) and chlordiazepoxide (CDZ) in pure and pharmaceutical formulations. ...
A sensitive and precise RP-HPLC method has been developed for the simultaneous estimation of clidinium bromide (CDB) and chlordiaz
Novel Stability-Indicating Chemometric-Assisted Spectrophotometric Methods for the Determination of Chlordiazepoxide and Clidinium Bromide in the Presence of Clidinium Bromide's Alkali-Induced Degradation Product.
Nessim CK, Michael AM, Fayez YM, Lotfy HM. Nessim CK, et al. J AOAC Int. 2018 May 1;101(3):714-722. doi: 10.5740/jaoacint.17-0096. Epub 2017 Sep 19. J AOAC Int. 2018. PMID: 28927485
Two simple and accurate chemometric-assisted spectrophotometric models were developed and validated for the simultaneous determination of chlordiazepoxide (CDZ) and clidinium bromide (CDB) in the presence of an alkali-induced degradation product of CDB in their pure …
Two simple and accurate chemometric-assisted spectrophotometric models were developed and validated for the simultaneous determination of …
Simultaneous determination of chlordiazepoxide and clidinium bromide in pharmaceutical formulations by derivative spectrophotometry.
Toral MI, Richter P, Lara N, Jaque P, Soto C, Saavedra M. Toral MI, et al. Int J Pharm. 1999 Oct 28;189(1):67-74. doi: 10.1016/s0378-5173(99)00238-0. Int J Pharm. 1999. PMID: 10518686
A direct and simple first derivative spectrophotometric method has been developed for the simultaneous determination of clidinium bromide and chlordiazepoxide in pharmaceutical formulations. ...The calibration graphs were linear in the ranges from 0.983 to 21.62 mg/ …
A direct and simple first derivative spectrophotometric method has been developed for the simultaneous determination of clidinium bro …
Stability-indicating HPLC method for simultaneous determination of clidinium bromide and chlordiazepoxide in combined dosage forms.
Pathak A, Rai P, Rajput SJ. Pathak A, et al. J Chromatogr Sci. 2010 Mar;48(3):235-9. doi: 10.1093/chromsci/48.3.235. J Chromatogr Sci. 2010. PMID: 20223092
The study describes development and subsequent validation of a stability indicating reverse-phase high-performance liquid chromatography method for the simultaneous estimation of clidinium bromide (CLI) and chlordiazepoxide (CHLOR) from their combination drug produc …
The study describes development and subsequent validation of a stability indicating reverse-phase high-performance liquid chromatography met …
Simultaneous spectrophotometric determination of chlordiazepoxide and clidinium using multivariate calibration techniques.
Khoshayand MR, Abdollahi H, Moeini A, Shamsaie A, Ghaffari A, Abbasian S. Khoshayand MR, et al. Drug Test Anal. 2010 Sep;2(9):430-5. doi: 10.1002/dta.162. Drug Test Anal. 2010. PMID: 20812297
Three multivariate modelling approaches including partial least squares regression (PLS), genetic algorithm-partial least squares regression (GA-PLS), and principal components-artificial neural network (PC-ANN) analysis were investigated for their application to the simultaneous …
Three multivariate modelling approaches including partial least squares regression (PLS), genetic algorithm-partial least squares regression …
Liquid chromatographic determination of clidinium bromide and clidinium bromide-chlordiazepoxide hydrochloride combinations in capsules.
Yuen SM, Lehr G. Yuen SM, et al. J Assoc Off Anal Chem. 1991 May-Jun;74(3):461-4. J Assoc Off Anal Chem. 1991. PMID: 1874688
A specific liquid chromatographic method was developed for determination of clidinium bromide and clidinium bromide-chlordiazepoxide hydrochloride combinations in capsules. ...The system was found to be free from any interferences from the 4 known related com …
A specific liquid chromatographic method was developed for determination of clidinium bromide and clidinium bromide-chlordi
Accidental acute clidinium toxicity.
Richardson SE, Edwards K. Richardson SE, et al. Emerg Med J. 2009 Jun;26(6):460. doi: 10.1136/emj.2008.067926. Emerg Med J. 2009. PMID: 19465630
Clidinium bromide (N-methyl-quinuclidinyl-benzylate) is a rarely used antimuscarinic drug that is marketed in combination with chlordiazepoxide as an antispasmodic for use in irritable bowel syndrome. A case is reported of an accidental staggered overdose of clid
Clidinium bromide (N-methyl-quinuclidinyl-benzylate) is a rarely used antimuscarinic drug that is marketed in combination with chl
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