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Page 1
Sweat chloride as a biomarker of CFTR activity: proof of concept and ivacaftor clinical trial data.
Accurso FJ, Van Goor F, Zha J, Stone AJ, Dong Q, Ordonez CL, Rowe SM, Clancy JP, Konstan MW, Hoch HE, Heltshe SL, Ramsey BW, Campbell PW, Ashlock MA. Accurso FJ, et al. J Cyst Fibros. 2014 Mar;13(2):139-47. doi: 10.1016/j.jcf.2013.09.007. J Cyst Fibros. 2014. PMID: 24660233 Free PMC article. Clinical Trial.
Standardization of sweat collection, processing,and analysis was employed for the first time. Sweat chloride and chloride ion transport (NPD) were integrated into a model of CFTR activity. RESULTS: Within-patient sweat chloride determinations showed sufficient preci …
Standardization of sweat collection, processing,and analysis was employed for the first time. Sweat chloride and chloride ion …
Effect of sodium-chloride ion difference on pH regulation.
Nozawa H, Tsuboi N, Nariai R, Nishimura N, Nakagawa S. Nozawa H, et al. Clin Biochem. 2021 Oct;96:75-77. doi: 10.1016/j.clinbiochem.2021.06.005. Epub 2021 Jun 28. Clin Biochem. 2021. PMID: 34197812 Clinical Trial.
This study investigated the effect of sodium-chloride ion difference (SCD) on pH regulation comparing with those of PaCO(2) and lactate. ...
This study investigated the effect of sodium-chloride ion difference (SCD) on pH regulation comparing with those of PaCO(2) an …
Cystic fibrosis transmembrane conductance regulator recruitment to phagosomes in neutrophils.
Zhou Y, Song K, Painter RG, Aiken M, Reiser J, Stanton BA, Nauseef WM, Wang G. Zhou Y, et al. J Innate Immun. 2013;5(3):219-30. doi: 10.1159/000346568. Epub 2013 Mar 6. J Innate Immun. 2013. PMID: 23486169 Free PMC article. Clinical Trial.
HOCl formation requires H2O2 produced by the NADPH oxidase, myeloperoxidase derived from azurophilic granules, and chloride ion. Chloride transport from cytoplasm into phagosomes requires chloride channels which include cystic fibrosis transmembrane conductance regu …
HOCl formation requires H2O2 produced by the NADPH oxidase, myeloperoxidase derived from azurophilic granules, and chloride ion …
Inhalation of Moli1901 in patients with cystic fibrosis.
Grasemann H, Stehling F, Brunar H, Widmann R, Laliberte TW, Molina L, Döring G, Ratjen F. Grasemann H, et al. Chest. 2007 May;131(5):1461-6. doi: 10.1378/chest.06-2085. Chest. 2007. PMID: 17494794 Clinical Trial.
BACKGROUND: In cystic fibrosis (CF) patients, the absence or dysfunction of the chloride channel CF transmembrane conductance regulator (CFTR) results in reduced chloride ion transport in respiratory epithelial cells. Moli1901 stimulates an alternative chloride chan …
BACKGROUND: In cystic fibrosis (CF) patients, the absence or dysfunction of the chloride channel CF transmembrane conductance regulator (CFT …
A pilot, open labelled, randomised controlled trial of hypertonic saline nasal irrigation and gargling for the common cold.
Ramalingam S, Graham C, Dove J, Morrice L, Sheikh A. Ramalingam S, et al. Sci Rep. 2019 Jan 31;9(1):1015. doi: 10.1038/s41598-018-37703-3. Sci Rep. 2019. PMID: 30705369 Free PMC article. Clinical Trial.
Since numerous viruses cause URTI, antiviral therapy is impractical. As we have evidence of chloride-ion dependent innate antiviral response in epithelial cells, we conducted a pilot, non-blinded, randomised controlled trial of hypertonic saline nasal irrigation and …
Since numerous viruses cause URTI, antiviral therapy is impractical. As we have evidence of chloride-ion dependent innate anti …
Venous blood gas analytes during isoflurane anesthesia in black-tailed prairie dogs (Cynomys ludovicianus).
Gardhouse SM, Eshar D, Bello N, Mason D. Gardhouse SM, et al. J Am Vet Med Assoc. 2015 Aug 15;247(4):404-8. doi: 10.2460/javma.247.4.404. J Am Vet Med Assoc. 2015. PMID: 26225612 Free article. Clinical Trial.
A significant increase from immediately after induction to completion of anesthesia was observed in Pco2 and mean blood chloride ion, BUN, and creatinine concentrations. A decrease in Po2, mean blood pH, and anion gap was observed from induction of anesthesia to com …
A significant increase from immediately after induction to completion of anesthesia was observed in Pco2 and mean blood chloride i …
NaCl and sugar release, salivation and taste during mastication of salted chewing gum.
Neyraud E, Prinz J, Dransfield E. Neyraud E, et al. Physiol Behav. 2003 Sep;79(4-5):731-7. doi: 10.1016/s0031-9384(03)00187-2. Physiol Behav. 2003. PMID: 12954416 Clinical Trial.
Changes in pH of saliva were more gradual, increasing to a maximum at about 2 min and remaining elevated after 4 min. Salty taste was related to the free chloride ion concentration in saliva irrespective of the initial salt concentration in the gum with an indicatio …
Changes in pH of saliva were more gradual, increasing to a maximum at about 2 min and remaining elevated after 4 min. Salty taste was relate …
Digital Pills to Measure Opioid Ingestion Patterns in Emergency Department Patients With Acute Fracture Pain: A Pilot Study.
Chai PR, Carreiro S, Innes BJ, Rosen RK, O'Cleirigh C, Mayer KH, Boyer EW. Chai PR, et al. J Med Internet Res. 2017 Jan 13;19(1):e19. doi: 10.2196/jmir.7050. J Med Internet Res. 2017. PMID: 28087496 Free PMC article. Clinical Trial.
The digital pill consisted of a digital radiofrequency emitter within a standard gelatin capsule that encapsulated an oxycodone tablet. When ingested, the gastric chloride ion gradient activated the digital pill, transmitting a radiofrequency signal that was receive …
The digital pill consisted of a digital radiofrequency emitter within a standard gelatin capsule that encapsulated an oxycodone tablet. When …
Controlling Salmonella infection in weanling pigs through water delivery of direct-fed microbials or organic acids: Part II. Effects on intestinal histology and active nutrient transport.
Walsh MC, Rostagno MH, Gardiner GE, Sutton AL, Richert BT, Radcliffe JS. Walsh MC, et al. J Anim Sci. 2012 Aug;90(8):2599-608. doi: 10.2527/jas.2010-3599. Epub 2012 Feb 17. J Anim Sci. 2012. PMID: 22344321 Clinical Trial.
Salmonella infection reduced basal short-circuit current (I(sc)); however, water-delivered DFM or organic acid treatments caused greater basal I(sc) on d 2 after challenge than did carbadox. Carbachol-induced chloride ion secretion was greatest in negative control p …
Salmonella infection reduced basal short-circuit current (I(sc)); however, water-delivered DFM or organic acid treatments caused greater bas …
Chemical specificity of coughing in man.
Godden DJ, Borland C, Lowry R, Higenbottam TW. Godden DJ, et al. Clin Sci (Lond). 1986 Mar;70(3):301-6. doi: 10.1042/cs0700301. Clin Sci (Lond). 1986. PMID: 3004799 Clinical Trial.
The occurrence of cough was found to be dependent on the concentration of chloride ions in the inhaled fluid, cough frequency progressively increasing as chloride ion concentration was reduced. It is proposed that the ion composition of the surface lining fluid of t …
The occurrence of cough was found to be dependent on the concentration of chloride ions in the inhaled fluid, cough frequency progressively …
25 results