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Sweat chloride as a biomarker of CFTR activity: proof of concept and ivacaftor clinical trial data.
Accurso FJ, Van Goor F, Zha J, Stone AJ, Dong Q, Ordonez CL, Rowe SM, Clancy JP, Konstan MW, Hoch HE, Heltshe SL, Ramsey BW, Campbell PW, Ashlock MA. Accurso FJ, et al. J Cyst Fibros. 2014 Mar;13(2):139-47. doi: 10.1016/j.jcf.2013.09.007. J Cyst Fibros. 2014. PMID: 24660233 Free PMC article. Clinical Trial.
METHODS: Sweat chloride and NPD were secondary endpoints in this placebo-controlled, multicenter trial. Standardization of sweat collection, processing,and analysis was employed for the first time. Sweat chloride and chloride ion transport (NPD) were i …
METHODS: Sweat chloride and NPD were secondary endpoints in this placebo-controlled, multicenter trial. Standardization of sweat coll …
[Effects of changes in ion concentrations, osmolarity, and pH on recovery from atracurium- or vecuronium-induced neuromuscular blockade].
Ortiz-Gómez JR, Palacio-Abizanda FJ, Fornet-Ruiz I. Ortiz-Gómez JR, et al. Rev Esp Anestesiol Reanim. 2009 Aug-Sep;56(7):403-11. doi: 10.1016/s0034-9356(09)70420-7. Rev Esp Anestesiol Reanim. 2009. PMID: 19856686 Clinical Trial. Spanish.
Two venous blood samples were extracted to measure ureic nitrogen, creatinine, glucose, ion concentrations (sodium, chloride, potassium, calcium, and magnesium), and osmolarity. ...RESULTS: The onset and duration of action for equipotent doses of atracurium and vecu …
Two venous blood samples were extracted to measure ureic nitrogen, creatinine, glucose, ion concentrations (sodium, chloride, …
Effect of sodium-chloride ion difference on pH regulation.
Nozawa H, Tsuboi N, Nariai R, Nishimura N, Nakagawa S. Nozawa H, et al. Clin Biochem. 2021 Oct;96:75-77. doi: 10.1016/j.clinbiochem.2021.06.005. Epub 2021 Jun 28. Clin Biochem. 2021. PMID: 34197812 Clinical Trial.
BACKGROUND: In the Stewart approach, the difference between the cation and anion concentrations, especially between sodium, accounting for the majority of cations, and chloride, comprising the majority of anions, is an important factor in pH regulation. This study investig …
BACKGROUND: In the Stewart approach, the difference between the cation and anion concentrations, especially between sodium, accounting for t …
Cystic fibrosis transmembrane conductance regulator recruitment to phagosomes in neutrophils.
Zhou Y, Song K, Painter RG, Aiken M, Reiser J, Stanton BA, Nauseef WM, Wang G. Zhou Y, et al. J Innate Immun. 2013;5(3):219-30. doi: 10.1159/000346568. Epub 2013 Mar 6. J Innate Immun. 2013. PMID: 23486169 Free PMC article. Clinical Trial.
HOCl formation requires H2O2 produced by the NADPH oxidase, myeloperoxidase derived from azurophilic granules, and chloride ion. Chloride transport from cytoplasm into phagosomes requires chloride channels which include cystic fibrosis transmembrane co …
HOCl formation requires H2O2 produced by the NADPH oxidase, myeloperoxidase derived from azurophilic granules, and chloride ion
Inhalation of Moli1901 in patients with cystic fibrosis.
Grasemann H, Stehling F, Brunar H, Widmann R, Laliberte TW, Molina L, Döring G, Ratjen F. Grasemann H, et al. Chest. 2007 May;131(5):1461-6. doi: 10.1378/chest.06-2085. Chest. 2007. PMID: 17494794 Clinical Trial.
BACKGROUND: In cystic fibrosis (CF) patients, the absence or dysfunction of the chloride channel CF transmembrane conductance regulator (CFTR) results in reduced chloride ion transport in respiratory epithelial cells. Moli1901 stimulates an alternative chl
BACKGROUND: In cystic fibrosis (CF) patients, the absence or dysfunction of the chloride channel CF transmembrane conductance regulat …
Venous blood gas analytes during isoflurane anesthesia in black-tailed prairie dogs (Cynomys ludovicianus).
Gardhouse SM, Eshar D, Bello N, Mason D. Gardhouse SM, et al. J Am Vet Med Assoc. 2015 Aug 15;247(4):404-8. doi: 10.2460/javma.247.4.404. J Am Vet Med Assoc. 2015. PMID: 26225612 Clinical Trial.
A significant increase from immediately after induction to completion of anesthesia was observed in Pco2 and mean blood chloride ion, BUN, and creatinine concentrations. A decrease in Po2, mean blood pH, and anion gap was observed from induction of anesthesia to com …
A significant increase from immediately after induction to completion of anesthesia was observed in Pco2 and mean blood chloride i
A pilot, open labelled, randomised controlled trial of hypertonic saline nasal irrigation and gargling for the common cold.
Ramalingam S, Graham C, Dove J, Morrice L, Sheikh A. Ramalingam S, et al. Sci Rep. 2019 Jan 31;9(1):1015. doi: 10.1038/s41598-018-37703-3. Sci Rep. 2019. PMID: 30705369 Free PMC article. Clinical Trial.
Since numerous viruses cause URTI, antiviral therapy is impractical. As we have evidence of chloride-ion dependent innate antiviral response in epithelial cells, we conducted a pilot, non-blinded, randomised controlled trial of hypertonic saline nasal irrigation and …
Since numerous viruses cause URTI, antiviral therapy is impractical. As we have evidence of chloride-ion dependent innate anti …
NaCl and sugar release, salivation and taste during mastication of salted chewing gum.
Neyraud E, Prinz J, Dransfield E. Neyraud E, et al. Physiol Behav. 2003 Sep;79(4-5):731-7. doi: 10.1016/s0031-9384(03)00187-2. Physiol Behav. 2003. PMID: 12954416 Clinical Trial.
Changes in pH of saliva were more gradual, increasing to a maximum at about 2 min and remaining elevated after 4 min. Salty taste was related to the free chloride ion concentration in saliva irrespective of the initial salt concentration in the gum with an indicatio …
Changes in pH of saliva were more gradual, increasing to a maximum at about 2 min and remaining elevated after 4 min. Salty taste was relate …
Digital Pills to Measure Opioid Ingestion Patterns in Emergency Department Patients With Acute Fracture Pain: A Pilot Study.
Chai PR, Carreiro S, Innes BJ, Rosen RK, O'Cleirigh C, Mayer KH, Boyer EW. Chai PR, et al. J Med Internet Res. 2017 Jan 13;19(1):e19. doi: 10.2196/jmir.7050. J Med Internet Res. 2017. PMID: 28087496 Free PMC article. Clinical Trial.
The digital pill consisted of a digital radiofrequency emitter within a standard gelatin capsule that encapsulated an oxycodone tablet. When ingested, the gastric chloride ion gradient activated the digital pill, transmitting a radiofrequency signal that was receive …
The digital pill consisted of a digital radiofrequency emitter within a standard gelatin capsule that encapsulated an oxycodone tablet. When …
A comparison of epidural blockade produced by plain 1% lidocaine and 1% lidocaine prepared by dilution of 2% lidocaine with the same volume of saline.
Kanai A, Hoka S. Kanai A, et al. Anesth Analg. 2006 Jun;102(6):1851-5. doi: 10.1213/01.ANE.0000219595.08935.9B. Anesth Analg. 2006. PMID: 16717336 Clinical Trial.
We randomized 40 patients scheduled for gynecological abdominal surgery under epidural anesthesia to one of two groups; those in group P received plain commercially prepared 1% lidocaine and those in group D received 1% lidocaine derived from 2% lidocaine and the same volume of s …
We randomized 40 patients scheduled for gynecological abdominal surgery under epidural anesthesia to one of two groups; those in group P rec …
25 results