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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1965 6
1966 6
1967 1
1968 2
1969 2
1970 3
1971 6
1972 5
1973 6
1974 9
1975 8
1976 11
1977 7
1978 7
1979 13
1980 15
1981 19
1982 15
1983 16
1984 22
1985 21
1986 25
1987 15
1988 19
1989 10
1990 23
1991 16
1992 15
1993 11
1994 10
1995 10
1996 10
1997 8
1998 8
1999 2
2000 8
2001 7
2002 6
2003 9
2004 6
2005 6
2006 7
2007 4
2008 9
2009 9
2010 3
2011 8
2012 14
2013 6
2014 11
2015 4
2016 13
2017 14
2018 11
2019 6
2020 3
2021 8
2022 13
2023 6
2024 2

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561 results

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Page 1
Chlorthalidone for Hypertension in Advanced Chronic Kidney Disease.
Agarwal R, Sinha AD, Cramer AE, Balmes-Fenwick M, Dickinson JH, Ouyang F, Tu W. Agarwal R, et al. N Engl J Med. 2021 Dec 30;385(27):2507-2519. doi: 10.1056/NEJMoa2110730. Epub 2021 Nov 5. N Engl J Med. 2021. PMID: 34739197 Free PMC article. Clinical Trial.
The percent change in the urinary albumin-to-creatinine ratio from baseline to 12 weeks was lower in the chlorthalidone group than in the placebo group by 50 percentage points (95% CI, 37 to 60). Hypokalemia, reversible increases in serum creatinine level, hyperglycemia, d …
The percent change in the urinary albumin-to-creatinine ratio from baseline to 12 weeks was lower in the chlorthalidone group than in …
Chlorthalidone vs. Hydrochlorothiazide for Hypertension-Cardiovascular Events.
Ishani A, Cushman WC, Leatherman SM, Lew RA, Woods P, Glassman PA, Taylor AA, Hau C, Klint A, Huang GD, Brophy MT, Fiore LD, Ferguson RE; Diuretic Comparison Project Writing Group. Ishani A, et al. N Engl J Med. 2022 Dec 29;387(26):2401-2410. doi: 10.1056/NEJMoa2212270. Epub 2022 Dec 14. N Engl J Med. 2022. PMID: 36516076 Clinical Trial.
BACKGROUND: Whether chlorthalidone is superior to hydrochlorothiazide for preventing major adverse cardiovascular events in patients with hypertension is unclear. ...There were no between-group differences in the occurrence of any of the components of the primary outcome. …
BACKGROUND: Whether chlorthalidone is superior to hydrochlorothiazide for preventing major adverse cardiovascular events in patients …
Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).
ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial. ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial. JAMA. 2002 Dec 18;288(23):2981-97. doi: 10.1001/jama.288.23.2981. JAMA. 2002. PMID: 12479763 Clinical Trial.
INTERVENTIONS: Participants were randomly assigned to receive chlorthalidone, 12.5 to 25 mg/d (n = 15 255); amlodipine, 2.5 to 10 mg/d (n = 9048); or lisinopril, 10 to 40 mg/d (n = 9054) for planned follow-up of approximately 4 to 8 years. ...For amlodipine vs chlorthal
INTERVENTIONS: Participants were randomly assigned to receive chlorthalidone, 12.5 to 25 mg/d (n = 15 255); amlodipine, 2.5 to 10 mg/ …
Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). SHEP Cooperative Research Group.
[No authors listed] [No authors listed] JAMA. 1991 Jun 26;265(24):3255-64. JAMA. 1991. PMID: 2046107 Clinical Trial.
INTERVENTIONS: --Participants were stratified by clinical center and by antihypertensive medication status at initial contact. For step 1 of the trial, dose 1 was chlorthalidone, 12.5 mg/d, or matching placebo; dose 2 was 25 mg/d. For step 2, dose 1 was atenolol, 25 mg/d, …
INTERVENTIONS: --Participants were stratified by clinical center and by antihypertensive medication status at initial contact. For step 1 of …
Efficacy and safety of standard dose triple combination of telmisartan 80 mg/amlodipine 5 mg/chlorthalidone 25 mg in primary hypertension: A randomized, double-blind, active-controlled, multicenter phase 3 trial.
Cho EJ, Kim MH, Kim YH, Chang K, Choi DJ, Kang WC, Shin J, Kim SH, Lee N, Son JW, Doh JH, Kim WS, Hong SJ, Rhee MY, Ahn Y, Lim SW, Hong SP, Choi SY, Hyon MS, Hwang JY, Kwon K, Cha KS, Ihm SH, Lee JH, Yoo BS, Kim HS. Cho EJ, et al. J Clin Hypertens (Greenwich). 2023 Sep;25(9):817-827. doi: 10.1111/jch.14707. Epub 2023 Aug 23. J Clin Hypertens (Greenwich). 2023. PMID: 37614053 Free PMC article. Clinical Trial.
The authors evaluated the efficacy, safety, and characteristics of patients who respond well to standard dose triple combination therapy including chlorthalidone 25 mg with telmisartan 80 mg plus amlodipine 5 mg in hypertensive patients. ...Patients are randomized to tripl …
The authors evaluated the efficacy, safety, and characteristics of patients who respond well to standard dose triple combination therapy inc …
A randomized trial of the efficacy and safety of azilsartan medoxomil combined with chlorthalidone.
Weber MA, Sever P, Juhasz A, Roberts A, Cao C. Weber MA, et al. J Renin Angiotensin Aldosterone Syst. 2018 Jul-Sep;19(3):1470320318795000. doi: 10.1177/1470320318795000. J Renin Angiotensin Aldosterone Syst. 2018. PMID: 30175930 Free PMC article. Clinical Trial.
INTRODUCTION: We measured the effects of azilsartan medoxomil co-administered with chlorthalidone 25 mg in stage 2 hypertension. METHODS: Azilsartan medoxomil 40 or 80 mg plus chlorthalidone were compared with placebo plus chlorthalidone once daily in a rando …
INTRODUCTION: We measured the effects of azilsartan medoxomil co-administered with chlorthalidone 25 mg in stage 2 hypertension. METH …
Comparative antiplatelet effects of chlorthalidone and hydrochlorothiazide.
Bashir K, Burns T, Pirruccello SJ, Aurit SJ, Hilleman DE. Bashir K, et al. J Clin Hypertens (Greenwich). 2022 Oct;24(10):1310-1315. doi: 10.1111/jch.14564. Epub 2022 Sep 6. J Clin Hypertens (Greenwich). 2022. PMID: 36067089 Free PMC article. Clinical Trial.
Chlorthalidone (CTD) may be superior to hydrochlorothiazide (HCTZ) in the reduction of adverse cardiovascular events in hypertensive patients. ...
Chlorthalidone (CTD) may be superior to hydrochlorothiazide (HCTZ) in the reduction of adverse cardiovascular events in hypertensive
Chlorthalidone vs Hydrochlorothiazide for Hypertension Treatment After Myocardial Infarction or Stroke: A Secondary Analysis of a Randomized Clinical Trial.
Ishani A, Hau C, Cushman WC, Leatherman SM, Lew RA, Glassman PA, Taylor AA, Ferguson RE. Ishani A, et al. JAMA Netw Open. 2024 May 1;7(5):e2411081. doi: 10.1001/jamanetworkopen.2024.11081. JAMA Netw Open. 2024. PMID: 38743423 Free PMC article. Clinical Trial.
IMPORTANCE: Patients with prior myocardial infarction (MI) or stroke have a greater risk of recurrent cardiovascular (CV) events. OBJECTIVE: To evaluate the association of chlorthalidone (CTD) vs hydrochlorothiazide (HCTZ) with CV outcomes and noncancer deaths in participa …
IMPORTANCE: Patients with prior myocardial infarction (MI) or stroke have a greater risk of recurrent cardiovascular (CV) events. OBJECTIVE: …
Clinical and demographic correlates of medication and visit adherence in a large randomized controlled trial.
Whittle J, Yamal JM, Williamson JD, Ford CE, Probstfield JL, Beard BL, Marginean H, Hamilton BP, Suhan PS, Davis BR; ALLHAT Collaborative Research Group. Whittle J, et al. BMC Health Serv Res. 2016 Jul 8;16:236. doi: 10.1186/s12913-016-1471-x. BMC Health Serv Res. 2016. PMID: 27391223 Free PMC article. Clinical Trial.
Virgin Islands for random assignment to antihypertensive treatment with amlodipine, chlorthalidone, or lisinopril. Site investigators reported clinic characteristics at the time they applied to participate in the study and research coordinators used standardized methods to …
Virgin Islands for random assignment to antihypertensive treatment with amlodipine, chlorthalidone, or lisinopril. Site investigators …
Effects of chlorthalidone plus amiloride compared with amlodipine on short-term blood pressure variability in individuals with hypertension and obstructive sleep apnea: a randomized controlled trial.
Lucca MB, Jorge JA, Cichelero FT, Martinez D, Borges RB, Hirakata VN, Fuchs FD, Fuchs SC. Lucca MB, et al. Blood Press Monit. 2023 Dec 1;28(6):289-294. doi: 10.1097/MBP.0000000000000663. Epub 2023 Jul 12. Blood Press Monit. 2023. PMID: 37466401 Free PMC article. Clinical Trial.
CONCLUSION: In brief, our study has shown that the use of chlorthalidone in combination with amiloride and amlodipine produces comparable effects on short-term BP variability in patients with hypertension and OSA. ...
CONCLUSION: In brief, our study has shown that the use of chlorthalidone in combination with amiloride and amlodipine produces compar …
561 results