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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1958 1
1959 1
1960 4
1961 1
1962 7
1963 4
1964 6
1965 2
1966 6
1967 8
1968 2
1969 3
1970 6
1971 1
1972 2
1973 2
1974 2
1975 1
1976 5
1978 4
1979 4
1980 1
1981 2
1982 2
1983 1
1984 2
1985 1
1986 3
1987 1
1988 5
1989 3
1990 5
1991 2
1992 6
1993 11
1994 15
1995 29
1996 33
1997 37
1998 50
1999 40
2000 32
2001 39
2002 32
2003 44
2004 31
2005 28
2006 42
2007 28
2008 24
2009 22
2010 21
2011 22
2012 32
2013 33
2014 29
2015 23
2016 28
2017 14
2018 27
2019 29
2020 27
2021 14
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873 results
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Page 1
Chlorzoxazone.
[No authors listed] [No authors listed] 2017 Jan 30. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. 2017 Jan 30. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. PMID: 31643467 Free Books & Documents. Review.
Chlorzoxazone is a centrally acting muscle relaxant commonly used for low back pain. Chlorzoxazone has been linked to rare instances of acute liver injury, a few of which have been fatal....
Chlorzoxazone is a centrally acting muscle relaxant commonly used for low back pain. Chlorzoxazone has been linked to rare ins
Interactions between herbal medicines and prescribed drugs: an updated systematic review.
Izzo AA, Ernst E. Izzo AA, et al. Drugs. 2009;69(13):1777-98. doi: 10.2165/11317010-000000000-00000. Drugs. 2009. PMID: 19719333 Review.
Ginseng (Panax ginseng) may interact with phenelzine and warfarin. Kava (Piper methysticum) increases the clearance of chlorzoxazone (a CYP2E1 substrate) and may interact with alprazolam, levodopa and paroxetine. Garlic (Allium sativum) interacts with chlorpropamide, fluin …
Ginseng (Panax ginseng) may interact with phenelzine and warfarin. Kava (Piper methysticum) increases the clearance of chlorzoxazone
CHLORZOXAZONE.
[No authors listed] [No authors listed] J Am Med Assoc. 1959 May 9;170(2):195. J Am Med Assoc. 1959. PMID: 13641004 No abstract available.
Loss-of-function BK channel mutation causes impaired mitochondria and progressive cerebellar ataxia.
Du X, Carvalho-de-Souza JL, Wei C, Carrasquel-Ursulaez W, Lorenzo Y, Gonzalez N, Kubota T, Staisch J, Hain T, Petrossian N, Xu M, Latorre R, Bezanilla F, Gomez CM. Du X, et al. Proc Natl Acad Sci U S A. 2020 Mar 17;117(11):6023-6034. doi: 10.1073/pnas.1920008117. Epub 2020 Mar 4. Proc Natl Acad Sci U S A. 2020. PMID: 32132200 Free PMC article.
When expressed in cerebellum via adenoassociated virus (AAV) viral transfection in mice, the mutant BK(G354S) channel, but not the BK(WT) channel, caused progressive impairment of several gait parameters consistent with cerebellar dysfunction from 40- to 80-d-old mice. Finally, t …
When expressed in cerebellum via adenoassociated virus (AAV) viral transfection in mice, the mutant BK(G354S) channel, but not the BK(WT) ch …
Action of chlorzoxazone on Ca(2)(+)movement and viability in human oral cancer cells.
Lu T, Liang WZ, Hao LJ, Kuo CC, Shieh P, Chou CT, Jan CR. Lu T, et al. Chin J Physiol. 2019 May-Jun;62(3):123-130. doi: 10.4103/CJP.CJP_20_19. Chin J Physiol. 2019. PMID: 31249266 Free article.
Chlorzoxazone is a skeletal muscle relaxant. However, the effect of chlorzoxazone on intracellular Ca(2+) concentrations ([Ca(2+)](i)) in oral cancer cells is unclear. ...Inhibition of phospholipase C (PLC) with U73122 did not alter chlorzoxazone-induced [Ca(
Chlorzoxazone is a skeletal muscle relaxant. However, the effect of chlorzoxazone on intracellular Ca(2+) concentrations ([Ca(
Adjuvant analgesics for spine surgery.
Nielsen RV. Nielsen RV. Dan Med J. 2018 Mar;65(3):B5468. Dan Med J. 2018. PMID: 29510816 Free article. Review.
Further, we discovered significantly higher pain levels in the dexamethasone group compared to placebo 1 year postoperatively. In study III we explored the effect of 500 mg of oral chlorzoxazone on acute postoperative pain and opioid consumption in patients with moderate t …
Further, we discovered significantly higher pain levels in the dexamethasone group compared to placebo 1 year postoperatively. In study III …
The effect of chlorzoxazone on acute pain after spine surgery. A randomized, blinded trial.
Nielsen RV, Fomsgaard JS, Siegel H, Martusevicius R, Mathiesen O, Dahl JB. Nielsen RV, et al. Acta Anaesthesiol Scand. 2016 Sep;60(8):1152-60. doi: 10.1111/aas.12754. Epub 2016 Jun 16. Acta Anaesthesiol Scand. 2016. PMID: 27306492 Clinical Trial.
Chlorzoxazone for low back pain is currently not advised due to the lack of placebo-controlled trials. We explored the effect of chlorzoxazone on acute pain after spine surgery. METHODS: One hundred and ten patients were randomly assigned to 500 mg oral chlorzoxa
Chlorzoxazone for low back pain is currently not advised due to the lack of placebo-controlled trials. We explored the effect of c
Investigating the Effect of Perioperative Chlorzoxazone on Acute Postoperative Pain After Total Hip and Knee Replacement Surgery.
Skrejborg P, Petersen KK, Beck J, Ulrich M, Simonsen O, Nielsen PT, Arendt-Nielsen L, Laursen M. Skrejborg P, et al. Clin J Pain. 2020 May;36(5):352-358. doi: 10.1097/AJP.0000000000000805. Clin J Pain. 2020. PMID: 31977370 Clinical Trial.
Despite this, chlorzoxazone is still used for acute postoperative pain management following total knee replacement (TKR) or total hip replacement (THR). The current randomized, double-blinded, placebo-controlled, parallel-group, clinical trial aimed to assess the effect of …
Despite this, chlorzoxazone is still used for acute postoperative pain management following total knee replacement (TKR) or total hip …
Simultaneous phenotyping of CYP2E1 and CYP3A using oral chlorzoxazone and midazolam microdoses.
Hohmann N, Blank A, Burhenne J, Suzuki Y, Mikus G, Haefeli WE. Hohmann N, et al. Br J Clin Pharmacol. 2019 Oct;85(10):2310-2320. doi: 10.1111/bcp.14040. Epub 2019 Aug 9. Br J Clin Pharmacol. 2019. PMID: 31222796 Free PMC article. Clinical Trial.
AIMS: Chlorzoxazone is the paradigm marker substrate for CYP2E1 phenotyping in vivo. ...Microdosing chlorzoxazone could circumvent this problem. METHOD: We enrolled 12 healthy volunteers in a trial investigating the dose-exposure relationship of single ascending …
AIMS: Chlorzoxazone is the paradigm marker substrate for CYP2E1 phenotyping in vivo. ...Microdosing chlorzoxazone could circum …
Obesity-induced CYP2E1 activity in children.
Gade C, Dalhoff K, Petersen T, Riis T, Schmeltz C, Chabanova E, Christensen HR, Mikus G, Burhenne J, Holm JC, Holst H. Gade C, et al. Br J Clin Pharmacol. 2019 Feb;85(2):458-459. doi: 10.1111/bcp.13813. Epub 2018 Dec 9. Br J Clin Pharmacol. 2019. PMID: 30537026 Free PMC article. No abstract available.
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