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Page 1
The CYTONOX trial.
Gade C, Mikus G, Christensen HR, Dalhoff KP, Holm JC, Holst H. Gade C, et al. Dan Med J. 2016 May;63(5):A5226. Dan Med J. 2016. PMID: 27127017 Free article. Clinical Trial.
The primary end points are: in vivo clearance of CYP3A4, CYP2E1 and CYP1A2 substrates, which will be defined by using well-tested probes; midazolam, chlorzoxazone and caffeine. Each of the probes will be administered as a single dose. Subsequently, blood and urine samples …
The primary end points are: in vivo clearance of CYP3A4, CYP2E1 and CYP1A2 substrates, which will be defined by using well-tested probes; mi …
Simultaneous phenotyping of CYP2E1 and CYP3A using oral chlorzoxazone and midazolam microdoses.
Hohmann N, Blank A, Burhenne J, Suzuki Y, Mikus G, Haefeli WE. Hohmann N, et al. Br J Clin Pharmacol. 2019 Oct;85(10):2310-2320. doi: 10.1111/bcp.14040. Epub 2019 Aug 9. Br J Clin Pharmacol. 2019. PMID: 31222796 Free PMC article. Clinical Trial.
Microdosing chlorzoxazone could circumvent this problem. METHOD: We enrolled 12 healthy volunteers in a trial investigating the dose-exposure relationship of single ascending chlorzoxazone oral doses over a 10,000-fold range (0.05-500 mg) and assessed the effect of …
Microdosing chlorzoxazone could circumvent this problem. METHOD: We enrolled 12 healthy volunteers in a trial investigating the dose- …
Effect of Clomethiazole Vs. Clorazepate on Hepatic Fat and Serum Transaminase Activities in Alcohol-Associated Liver Disease: Results from a Randomized, Controlled Phase II Clinical Trial.
Hohmann N, Schröder F, Moreira B, Teng H, Burhenne J, Bruckner T, Mueller S, Haefeli WE, Seitz HK. Hohmann N, et al. Alcohol Alcohol. 2023 Mar 10;58(2):134-141. doi: 10.1093/alcalc/agac068. Alcohol Alcohol. 2023. PMID: 36562601 Free article. Clinical Trial.
Sixty patients were randomly assigned to ADT with either CMZ or clorazepate (CZP) for 7-10 days in a 1:1 ratio. The chlorzoxazone test of CYP2E1 activity was performed at enrolment and at 2 points during the study. ...
Sixty patients were randomly assigned to ADT with either CMZ or clorazepate (CZP) for 7-10 days in a 1:1 ratio. The chlorzoxazone tes …
Variability in the disposition of chlorzoxazone.
de Vries JD, Salphati L, Horie S, Becker CE, Hoener BA. de Vries JD, et al. Biopharm Drug Dispos. 1994 Oct;15(7):587-97. doi: 10.1002/bdd.2510150706. Biopharm Drug Dispos. 1994. PMID: 7849234 Clinical Trial.
Chlorzoxazone is 6-hydroxylated by cytochrome P450 2E1 (CYP 2E1), which bioactivates many toxic and carcinogenic molecules. ...These results suggested that there was considerable inter-individual variability in the metabolism of chlorzoxazone to 6-hydroxychlorzoxazo …
Chlorzoxazone is 6-hydroxylated by cytochrome P450 2E1 (CYP 2E1), which bioactivates many toxic and carcinogenic molecules. ...These …
Effects of cigarette smoking and carbon monoxide on chlorzoxazone and caffeine metabolism.
Benowitz NL, Peng M, Jacob P 3rd. Benowitz NL, et al. Clin Pharmacol Ther. 2003 Nov;74(5):468-74. doi: 10.1016/j.clpt.2003.07.001. Clin Pharmacol Ther. 2003. PMID: 14586387 Clinical Trial.
In each treatment condition, subjects received oral chlorzoxazone (250 mg) and caffeine (250 mg) with measurement of disposition kinetics and urine metabolite profiles. ...Considerable individual variability was noted in the extent of induction of metabolism by cigarette s …
In each treatment condition, subjects received oral chlorzoxazone (250 mg) and caffeine (250 mg) with measurement of disposition kine …
Liver disease selectively modulates cytochrome P450--mediated metabolism.
Frye RF, Zgheib NK, Matzke GR, Chaves-Gnecco D, Rabinovitz M, Shaikh OS, Branch RA. Frye RF, et al. Clin Pharmacol Ther. 2006 Sep;80(3):235-45. doi: 10.1016/j.clpt.2006.05.006. Clin Pharmacol Ther. 2006. PMID: 16952490 Clinical Trial.
All participants received a cocktail of 4 oral drugs simultaneously, caffeine, mephenytoin, debrisoquin (INN, debrisoquine), and chlorzoxazone, as in vivo probes of the drug-metabolizing enzymes CYP1A2, CYP2C19, CYP2D6, and CYP2E1, respectively. ...In comparison with contr …
All participants received a cocktail of 4 oral drugs simultaneously, caffeine, mephenytoin, debrisoquin (INN, debrisoquine), and chlorzox …
Validation of incorporating flurbiprofen into the Pittsburgh cocktail.
Zgheib NK, Frye RF, Tracy TS, Romkes M, Branch RA. Zgheib NK, et al. Clin Pharmacol Ther. 2006 Sep;80(3):257-63. doi: 10.1016/j.clpt.2006.06.005. Clin Pharmacol Ther. 2006. PMID: 16952492 Clinical Trial.
METHODS: In a randomized, 3-way, Latin-square, crossover-design study, 24 healthy subjects (mean age [+/-SD], 47.8 +/- 15.1 years) received flurbiprofen (50 mg) and the Pittsburgh 5-drug cocktail (100 mg caffeine, 100 mg mephenytoin, 10 mg debrisoquin [INN, debrisoquine], 250 mg …
METHODS: In a randomized, 3-way, Latin-square, crossover-design study, 24 healthy subjects (mean age [+/-SD], 47.8 +/- 15.1 years) received …
Phenotyping of cytochrome P450 2E1 in vitro and in vivo.
Ernstgård L, Johanson G, Karlsson AS, Warholm M. Ernstgård L, et al. Curr Drug Metab. 2007 Jun;8(5):493-8. doi: 10.2174/138920007780866843. Curr Drug Metab. 2007. PMID: 17584020 Clinical Trial.
The administered dose as well as the absorption of the probe influences the chlorzoxazone ratio. We suggest that a dose of 10 mg chlorzoxazone per kg body weight is used to estimate the CYP2E1 phenotype. Further, metabolic ratios should be disregarded if the sum of …
The administered dose as well as the absorption of the probe influences the chlorzoxazone ratio. We suggest that a dose of 10 mg c …
Altered cytochrome 2E1 and 3A P450-dependent drug metabolism in advanced ovarian cancer correlates to tumour-associated inflammation.
Trousil S, Lee P, Edwards RJ, Maslen L, Lozan-Kuehne JP, Ramaswami R, Aboagye EO, Clarke S, Liddle C, Sharma R. Trousil S, et al. Br J Pharmacol. 2019 Sep;176(18):3712-3722. doi: 10.1111/bph.14776. Epub 2019 Aug 5. Br J Pharmacol. 2019. PMID: 31236938 Free PMC article. Clinical Trial.
EXPERIMENTAL APPROACH: Patients with advanced stage ovarian cancer and healthy volunteers were recruited. Participants received caffeine, chlorzoxazone, dextromethorphan, and omeprazole as in vivo probes for CYP1A2, CYP2E1, CYP2D6, CYP3A, and CYP2C19. ...KEY RESULTS: CYP2E …
EXPERIMENTAL APPROACH: Patients with advanced stage ovarian cancer and healthy volunteers were recruited. Participants received caffeine, …
Higher chlorzoxazone clearance in obese children compared with nonobese peers.
Gade C, Dalhoff K, Petersen TS, Riis T, Schmeltz C, Chabanova E, Christensen HR, Mikus G, Burhenne J, Holm JC, Holst H. Gade C, et al. Br J Clin Pharmacol. 2018 Aug;84(8):1738-1747. doi: 10.1111/bcp.13602. Epub 2018 Jun 3. Br J Clin Pharmacol. 2018. PMID: 29618168 Free PMC article. Clinical Trial.
METHODS: Seventy children were divided into groups by body mass index (BMI) standard deviation score (SDS). All children received 250 mg oral chlorzoxazone (CLZ) as probe for CYP2E1 activity. Thirteen blood samples and 20-h urine samples were collected per participant. ...
METHODS: Seventy children were divided into groups by body mass index (BMI) standard deviation score (SDS). All children received 250 mg ora …
57 results