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1970 1
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1977 62
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1979 50
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1982 35
1983 50
1984 54
1985 39
1986 59
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1988 65
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1990 127
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1999 461
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2002 406
2003 436
2004 461
2005 486
2006 480
2007 507
2008 488
2009 428
2010 446
2011 489
2012 470
2013 495
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2015 464
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2017 526
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16,224 results

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Page 1
Unique Effects of Clozapine: A Pharmacological Perspective.
Khokhar JY, Henricks AM, Sullivan EDK, Green AI. Khokhar JY, et al. Adv Pharmacol. 2018;82:137-162. doi: 10.1016/bs.apha.2017.09.009. Epub 2018 Jan 12. Adv Pharmacol. 2018. PMID: 29413518 Free PMC article. Review.
This chapter reviews clozapine's unique clinical effects and unusual pharmacological profile. In addition to its effects in treatment-resistant schizophrenia, clozapine has been shown to decrease suicidality, which occurs at an increased rate in patients with …
This chapter reviews clozapine's unique clinical effects and unusual pharmacological profile. In addition to its effects in tr …
Clozapine for the treatment-resistant schizophrenic. A double-blind comparison with chlorpromazine.
Kane J, Honigfeld G, Singer J, Meltzer H. Kane J, et al. Arch Gen Psychiatry. 1988 Sep;45(9):789-96. doi: 10.1001/archpsyc.1988.01800330013001. Arch Gen Psychiatry. 1988. PMID: 3046553 Clinical Trial.
This report describes a multicenter clinical trial to assess clozapine's efficacy in the treatment of patients who are refractory to neuroleptics. DSM-III schizophrenics who had failed to respond to at least three different neuroleptics underwent a prospective, sing …
This report describes a multicenter clinical trial to assess clozapine's efficacy in the treatment of patients who are refract …
Clozapine.
[No authors listed] [No authors listed] Lancet. 1989 Dec 16;2(8677):1430-2. Lancet. 1989. PMID: 2574365 Review. No abstract available.
Efficacy of clozapine versus second-generation antipsychotics in people with treatment-resistant schizophrenia: a systematic review and individual patient data meta-analysis.
Schneider-Thoma J, Hamza T, Chalkou K, Siafis S, Dong S, Bighelli I, Hansen WP, Scheuring E, Davis JM, Priller J, Baumann P, Conley R, Cordes J, Kelly D, Kluge M, Kumra S, Lewis S, Meltzer HY, Naber D, Schooler N, Volavka J, Wahlbeck K, Salanti G, Leucht S. Schneider-Thoma J, et al. Lancet Psychiatry. 2025 Apr;12(4):254-265. doi: 10.1016/S2215-0366(25)00001-X. Epub 2025 Feb 26. Lancet Psychiatry. 2025. PMID: 40023172 Free article.
BACKGROUND: Clozapine is recommended by national and international guidelines for people with treatment-resistant schizophrenia. ...It is limited by unavailability of IPD for some studies, uncaptured sources of variance, and uncertainty due to premature study discontinuati …
BACKGROUND: Clozapine is recommended by national and international guidelines for people with treatment-resistant schizophrenia. ...I …
Why Is Clozapine Uniquely Effective in Treatment-Resistant Schizophrenia? A Review and Proposal.
Murray RM, Egerton A, Gao Y, Grace AA, Howes O, Jauhar S, Leucht S, Chen EYH, MacCabe JH, McCutcheon RA, Natesan S, Taylor D. Murray RM, et al. Biol Psychiatry. 2026 Apr 1;99(7):517-526. doi: 10.1016/j.biopsych.2025.06.011. Epub 2025 Jun 23. Biol Psychiatry. 2026. PMID: 40562225 Free article. Review.
A great deal is known about the use, benefits, and side effects of clozapine in treatment-resistant schizophrenia (TRS). However, why clozapine is more effective than other antipsychotics in TRS remains unclear. ...These effects are likely crucial to clozapine …
A great deal is known about the use, benefits, and side effects of clozapine in treatment-resistant schizophrenia (TRS). However, why …
Clozapine and all-cause mortality in treatment-resistant schizophrenia: a historical cohort study.
Cho J, Hayes RD, Jewell A, Kadra G, Shetty H, MacCabe JH, Downs J. Cho J, et al. Acta Psychiatr Scand. 2019 Mar;139(3):237-247. doi: 10.1111/acps.12989. Epub 2018 Dec 16. Acta Psychiatr Scand. 2019. PMID: 30478891 Free PMC article.
OBJECTIVE: Large-scale epidemiological studies have demonstrated a protective effect of clozapine on mortality in people with schizophrenia. Clozapine is reserved for use in patients with treatment-resistant schizophrenia (TRS), but evidence of clozapine's …
OBJECTIVE: Large-scale epidemiological studies have demonstrated a protective effect of clozapine on mortality in people with schizop …
Effect of Valproate Coprescription on Clozapine Pharmacokinetics in Clinical Practice.
Flanagan RJ, Obee SJ, Kim AHM, Every-Palmer S. Flanagan RJ, et al. J Clin Psychopharmacol. 2024 Nov-Dec;44(6):561-569. doi: 10.1097/JCP.0000000000001923. J Clin Psychopharmacol. 2024. PMID: 39836512
However, the effect of valproate on clozapine metabolism and on the incidence of clozapine-related side effects is unclear. METHODS: We compared clozapine dose and plasma clozapine and N-desmethylclozapine (norclozapine) concentrations in smokers and n …
However, the effect of valproate on clozapine metabolism and on the incidence of clozapine-related side effects is unclear. ME …
Clozapine, a fast-off-D2 antipsychotic.
Seeman P. Seeman P. ACS Chem Neurosci. 2014 Jan 15;5(1):24-9. doi: 10.1021/cn400189s. Epub 2013 Nov 18. ACS Chem Neurosci. 2014. PMID: 24219174 Free PMC article. Review.
The chemical structure of clozapine facilitates a relatively rapid dissociation from D2 receptors. After short-term occupation of D2 receptors, peak neural activity raises synaptic dopamine, which then displaces clozapine. ...Clozapine's transient occu …
The chemical structure of clozapine facilitates a relatively rapid dissociation from D2 receptors. After short-term occupation of D2 …
Clozapine-caused eosinophilic colitis.
Friedberg JW, Frankenburg FR, Burk J, Johnson W. Friedberg JW, et al. Ann Clin Psychiatry. 1995 Jun;7(2):97-8. doi: 10.3109/10401239509149034. Ann Clin Psychiatry. 1995. PMID: 8556100
Four patients with diarrhea and eosinophilia associated with clozapine therapy are presented. In two cases clozapine therapy was interrupted but then restarted; all patients eventually tolerated clozapine well. A syndrome of clozapine-induced eosinophi …
Four patients with diarrhea and eosinophilia associated with clozapine therapy are presented. In two cases clozapine therapy w …
Analysis of clinical studies on clozapine from 2012-2022.
Freibüchler A, Seifert R. Freibüchler A, et al. Naunyn Schmiedebergs Arch Pharmacol. 2024 Dec;397(12):9745-9765. doi: 10.1007/s00210-024-03209-1. Epub 2024 Jun 25. Naunyn Schmiedebergs Arch Pharmacol. 2024. PMID: 38918233 Free PMC article. Review.
Sixty-four studies were included and categorised by topic. The pharmacokinetic properties of clozapine tablets and a clozapine suspension solution did not differ markedly. Clozapine was superior to olanzapine and risperidone in reducing aggression and depress …
Sixty-four studies were included and categorised by topic. The pharmacokinetic properties of clozapine tablets and a clozapine …
16,224 results
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