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Year Number of Results
1970 1
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1973 9
1974 25
1975 49
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1977 62
1978 54
1979 50
1980 52
1981 30
1982 35
1983 50
1984 54
1985 39
1986 59
1987 48
1988 65
1989 95
1990 127
1991 145
1992 219
1993 265
1994 364
1995 378
1996 419
1997 391
1998 410
1999 461
2000 421
2001 424
2002 406
2003 436
2004 461
2005 486
2006 480
2007 507
2008 488
2009 428
2010 446
2011 489
2012 470
2013 494
2014 480
2015 464
2016 543
2017 526
2018 511
2019 560
2020 588
2021 684
2022 641
2023 604
2024 568
2025 3

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15,270 results

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Page 1
Unique Effects of Clozapine: A Pharmacological Perspective.
Khokhar JY, Henricks AM, Sullivan EDK, Green AI. Khokhar JY, et al. Adv Pharmacol. 2018;82:137-162. doi: 10.1016/bs.apha.2017.09.009. Epub 2018 Jan 12. Adv Pharmacol. 2018. PMID: 29413518 Free PMC article. Review.
This chapter reviews clozapine's unique clinical effects and unusual pharmacological profile. In addition to its effects in treatment-resistant schizophrenia, clozapine has been shown to decrease suicidality, which occurs at an increased rate in patients with …
This chapter reviews clozapine's unique clinical effects and unusual pharmacological profile. In addition to its effects in tr …
Pharmacokinetics and pharmacodynamics of clozapine.
Jann MW, Grimsley SR, Gray EC, Chang WH. Jann MW, et al. Clin Pharmacokinet. 1993 Feb;24(2):161-76. doi: 10.2165/00003088-199324020-00005. Clin Pharmacokinet. 1993. PMID: 8453823 Review.
Clozapine is metabolised via the hepatic microsomal enzyme system into 2 principle metabolites: demethyl-clozapine and clozapine N-oxide. Urine samples have reported the ratio of clozapine:demethyl:N-oxide to be 1:1:2. The clozapine N-oxide bind
Clozapine is metabolised via the hepatic microsomal enzyme system into 2 principle metabolites: demethyl-clozapine and cloz
Clozapine for the treatment-resistant schizophrenic. A double-blind comparison with chlorpromazine.
Kane J, Honigfeld G, Singer J, Meltzer H. Kane J, et al. Arch Gen Psychiatry. 1988 Sep;45(9):789-96. doi: 10.1001/archpsyc.1988.01800330013001. Arch Gen Psychiatry. 1988. PMID: 3046553 Clinical Trial.
This report describes a multicenter clinical trial to assess clozapine's efficacy in the treatment of patients who are refractory to neuroleptics. DSM-III schizophrenics who had failed to respond to at least three different neuroleptics underwent a prospective, sing …
This report describes a multicenter clinical trial to assess clozapine's efficacy in the treatment of patients who are refract …
Prevention of suicide by clozapine in mental disorders: systematic review.
Masdrakis VG, Baldwin DS. Masdrakis VG, et al. Eur Neuropsychopharmacol. 2023 Apr;69:4-23. doi: 10.1016/j.euroneuro.2022.12.011. Epub 2023 Jan 12. Eur Neuropsychopharmacol. 2023. PMID: 36640481 Free article. Review.
BACKGROUND: Previous research has investigated the efficacy of clozapine in reducing suicidality in patients with schizophrenia and schizoaffective disorder. ...No consensus exists as to whether other antipsychotic drugs share this effect. Discontinuation of clozapine
BACKGROUND: Previous research has investigated the efficacy of clozapine in reducing suicidality in patients with schizophrenia and s …
Clozapine, a fast-off-D2 antipsychotic.
Seeman P. Seeman P. ACS Chem Neurosci. 2014 Jan 15;5(1):24-9. doi: 10.1021/cn400189s. Epub 2013 Nov 18. ACS Chem Neurosci. 2014. PMID: 24219174 Free PMC article. Review.
The chemical structure of clozapine facilitates a relatively rapid dissociation from D2 receptors. After short-term occupation of D2 receptors, peak neural activity raises synaptic dopamine, which then displaces clozapine. ...Clozapine's transient occu …
The chemical structure of clozapine facilitates a relatively rapid dissociation from D2 receptors. After short-term occupation of D2 …
Promoting safer and wider worldwide use of clozapine.
de Leon J. de Leon J. Schizophr Res. 2024 Jun;268:1-6. doi: 10.1016/j.schres.2024.03.003. Epub 2024 Mar 22. Schizophr Res. 2024. PMID: 38519290
This issue focuses on the past, the present and the future of clozapine. Of the 43 clozapine articles, nine are historical articles dealing with the past, 29 deal with the present and five with laboratory assays which may influence its future use. ...
This issue focuses on the past, the present and the future of clozapine. Of the 43 clozapine articles, nine are historical art …
Meta-analysis of clozapine and insomnia in schizophrenia.
Miller BJ, McEvoy JP, McCall WV. Miller BJ, et al. Schizophr Res. 2023 Feb;252:208-215. doi: 10.1016/j.schres.2023.01.018. Epub 2023 Jan 18. Schizophr Res. 2023. PMID: 36669344
INTRODUCTION: Insomnia commonly occurs in schizophrenia, and insomnia is associated with suicide risk. Clozapine has anti-suicidal properties and beneficial effects on sleep. We performed a meta-analysis of insomnia in randomized controlled trials (RCTs) of patients with s …
INTRODUCTION: Insomnia commonly occurs in schizophrenia, and insomnia is associated with suicide risk. Clozapine has anti-suicidal pr …
Evaluating Monitoring Guidelines of Clozapine-Induced Adverse Effects: a Systematic Review.
Smessaert S, Detraux J, Desplenter F, De Hert M. Smessaert S, et al. CNS Drugs. 2024 Feb;38(2):105-123. doi: 10.1007/s40263-023-01054-z. Epub 2024 Jan 18. CNS Drugs. 2024. PMID: 38236524
Guidelines aiming to address the monitoring of clozapine's (serious) adverse effects can be helpful to prevent and treat these effects. ...Studies reporting on the monitoring of adverse effects of clozapine without being a formal guideline, guidelines reporti …
Guidelines aiming to address the monitoring of clozapine's (serious) adverse effects can be helpful to prevent and treat these …
Clozapine as a Model for Antipsychotic Development.
Nucifora FC Jr, Mihaljevic M, Lee BJ, Sawa A. Nucifora FC Jr, et al. Neurotherapeutics. 2017 Jul;14(3):750-761. doi: 10.1007/s13311-017-0552-9. Neurotherapeutics. 2017. PMID: 28653280 Free PMC article. Review.
In this review, we discuss the history of clozapine, landmark studies, and its clinical advantages and disadvantages. We further discuss the hypotheses for clozapine's superior efficacy based on neuroreceptor binding, and the limitations of a receptor-based a …
In this review, we discuss the history of clozapine, landmark studies, and its clinical advantages and disadvantages. We further disc …
Clozapine.
[No authors listed] [No authors listed] Lancet. 1989 Dec 16;2(8677):1430-2. Lancet. 1989. PMID: 2574365 Review. No abstract available.
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