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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1973 1
1974 10
1975 5
1976 6
1977 4
1978 9
1979 7
1980 2
1983 2
1984 3
1985 1
1986 2
1987 6
1988 11
1989 6
1990 7
1991 7
1992 7
1993 16
1994 34
1995 26
1996 43
1997 41
1998 46
1999 59
2000 40
2001 36
2002 24
2003 43
2004 60
2005 38
2006 40
2007 35
2008 31
2009 42
2010 27
2011 26
2012 23
2013 18
2014 12
2015 12
2016 18
2017 20
2018 21
2019 13
2020 14
2021 9
2022 7
2023 0

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911 results

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Page 1
Comparison of Acute Followed by Maintenance ECT vs Clozapine on Psychopathology and Regional Cerebral Blood Flow in Treatment-Resistant Schizophrenia: A Randomized Controlled Trial.
Mishra BR, Agrawal K, Biswas T, Mohapatra D, Nath S, Maiti R. Mishra BR, et al. Schizophr Bull. 2022 Jun 21;48(4):814-825. doi: 10.1093/schbul/sbac027. Schizophr Bull. 2022. PMID: 35556138 Free PMC article. Clinical Trial.
BACKGROUND AND HYPOTHESIS: In treatment-resistant schizophrenia (TRS), Clozapine is only approved treatment with undesirable side-effects, warranting better alternatives. Our hypothesis is acute followed by maintenance Electroconvulsive Therapy (M-ECT) will be comparable i …
BACKGROUND AND HYPOTHESIS: In treatment-resistant schizophrenia (TRS), Clozapine is only approved treatment with undesirable side-eff …
Clozapine for the treatment-resistant schizophrenic. A double-blind comparison with chlorpromazine.
Kane J, Honigfeld G, Singer J, Meltzer H. Kane J, et al. Arch Gen Psychiatry. 1988 Sep;45(9):789-96. doi: 10.1001/archpsyc.1988.01800330013001. Arch Gen Psychiatry. 1988. PMID: 3046553 Clinical Trial.
This report describes a multicenter clinical trial to assess clozapine's efficacy in the treatment of patients who are refractory to neuroleptics. ...Patients whose condition remained unimproved were then randomly assigned, in a double-blind manner, to clozapine …
This report describes a multicenter clinical trial to assess clozapine's efficacy in the treatment of patients who are refract …
The Importance of Conduct Disorder in the Treatment of Violence in Schizophrenia: Efficacy of Clozapine Compared With Olanzapine and Haloperidol.
Krakowski M, Tural U, Czobor P. Krakowski M, et al. Am J Psychiatry. 2021 Mar 1;178(3):266-274. doi: 10.1176/appi.ajp.2020.20010052. Epub 2021 Jan 21. Am J Psychiatry. 2021. PMID: 33472389 Clinical Trial.
Clozapine's greater antiaggressive efficacy over haloperidol was substantially more pronounced in patients with conduct disorder than in patients without conduct disorder. ...When conduct disorder is present, clozapine is the optimal treatment....
Clozapine's greater antiaggressive efficacy over haloperidol was substantially more pronounced in patients with conduct disord …
Electroconvulsive therapy augmentation in clozapine-resistant schizophrenia: a prospective, randomized study.
Petrides G, Malur C, Braga RJ, Bailine SH, Schooler NR, Malhotra AK, Kane JM, Sanghani S, Goldberg TE, John M, Mendelowitz A. Petrides G, et al. Am J Psychiatry. 2015 Jan;172(1):52-8. doi: 10.1176/appi.ajp.2014.13060787. Epub 2014 Oct 31. Am J Psychiatry. 2015. PMID: 25157964 Clinical Trial.
The authors examined the use of ECT as an augmentation to clozapine for treatment-refractory schizophrenia. METHOD: In a randomized single-blind 8-week study, patients with clozapine-resistant schizophrenia were assigned to treatment as usual (clozapine group …
The authors examined the use of ECT as an augmentation to clozapine for treatment-refractory schizophrenia. METHOD: In a randomized s …
Amisulpride augmentation therapy improves cognitive performance and psychopathology in clozapine-resistant treatment-refractory schizophrenia: a 12-week randomized, double-blind, placebo-controlled trial.
Zhu MH, Liu ZJ, Hu QY, Yang JY, Jin Y, Zhu N, Huang Y, Shi DH, Liu MJ, Tan HY, Zhao L, Lv QY, Yi ZH, Wu FC, Li ZZ. Zhu MH, et al. Mil Med Res. 2022 Oct 18;9(1):59. doi: 10.1186/s40779-022-00420-0. Mil Med Res. 2022. PMID: 36253804 Free PMC article. Clinical Trial.
BACKGROUND: Although clozapine is an effective option for treatment-resistant schizophrenia (TRS), there are still 1/3 to 1/2 of TRS patients who do not respond to clozapine. ...METHODS: A total of 80 patients were recruited and randomly assigned to receive initial …
BACKGROUND: Although clozapine is an effective option for treatment-resistant schizophrenia (TRS), there are still 1/3 to 1/2 of TRS …
Combination treatment with clozapine and paroxetine in schizophrenia: safety and tolerability data from a prospective open clinical trial.
Anghelescu I, Szegedi A, Schlegel S, Weigmann H, Hiemke C, Wetzel H. Anghelescu I, et al. Eur Neuropsychopharmacol. 1998 Dec;8(4):315-20. doi: 10.1016/s0924-977x(97)00093-x. Eur Neuropsychopharmacol. 1998. PMID: 9928923 Clinical Trial.
Clozapine is a drug with many side effects, some of them with potentially hazardous outcome (e.g. seizures, agranulocytosis), if not carefully monitored. It has been shown that the metabolism of clozapine may be affected by concomitant treatment with selective serot …
Clozapine is a drug with many side effects, some of them with potentially hazardous outcome (e.g. seizures, agranulocytosis), if not …
Effects of adjunctive treatment with aripiprazole on body weight and clinical efficacy in schizophrenia patients treated with clozapine: a randomized, double-blind, placebo-controlled trial.
Fleischhacker WW, Heikkinen ME, Olié JP, Landsberg W, Dewaele P, McQuade RD, Loze JY, Hennicken D, Kerselaers W. Fleischhacker WW, et al. Int J Neuropsychopharmacol. 2010 Sep;13(8):1115-25. doi: 10.1017/S1461145710000490. Epub 2010 May 12. Int J Neuropsychopharmacol. 2010. PMID: 20459883 Free article. Clinical Trial.
Clozapine is associated with significant weight gain and metabolic disturbances. ...Outpatients who met DSM-IV-TR criteria for schizophrenia, who were not optimally controlled while on stable dosage of clozapine for > or =3 months and had experienced weight gain …
Clozapine is associated with significant weight gain and metabolic disturbances. ...Outpatients who met DSM-IV-TR criteria for schizo …
Update on the clinical efficacy and side effects of clozapine.
Safferman A, Lieberman JA, Kane JM, Szymanski S, Kinon B. Safferman A, et al. Schizophr Bull. 1991;17(2):247-61. doi: 10.1093/schbul/17.2.247. Schizophr Bull. 1991. PMID: 1882209 Review.
Clozapine (CLOZ) is an atypical antipsychotic drug being used with increasing frequency throughout the world and has recently been commercially marketed in the United States. ...In addition, important questions remain as to what other conditions might be indications for CL …
Clozapine (CLOZ) is an atypical antipsychotic drug being used with increasing frequency throughout the world and has recently been co …
Steady-State Clozapine and Norclozapine Pharmacokinetics in Maori and European Patients.
Menkes DB, Glue P, Gale C, Lam F, Hung CT, Hung N. Menkes DB, et al. EBioMedicine. 2018 Jan;27:134-137. doi: 10.1016/j.ebiom.2017.11.030. Epub 2017 Dec 13. EBioMedicine. 2018. PMID: 29254680 Free PMC article. Clinical Trial.
BACKGROUND: Clozapine is the most effective drug for treatment-resistant schizophrenia, but its use is limited by toxicity. ...METHODS: Clozapine and norclozapine steady state bioavailability was assessed over 24h under fasting and fed conditions in 12 Maori and 16 …
BACKGROUND: Clozapine is the most effective drug for treatment-resistant schizophrenia, but its use is limited by toxicity. ...METHOD …
Clinical and neurocognitive effects of clozapine and risperidone in treatment-refractory schizophrenic patients: a prospective study.
Lindenmayer JP, Iskander A, Park M, Apergi FS, Czobor P, Smith R, Allen D. Lindenmayer JP, et al. J Clin Psychiatry. 1998 Oct;59(10):521-7. doi: 10.4088/jcp.v59n1005. J Clin Psychiatry. 1998. PMID: 9818633 Clinical Trial.
BACKGROUND: Few controlled studies have compared the efficacy of clozapine and risperidone in treatment-refractory schizophrenic patients. ...Patients taking clozapine showed a gradual improvement that occurred over the entire length of the trial. ...
BACKGROUND: Few controlled studies have compared the efficacy of clozapine and risperidone in treatment-refractory schizophrenic pati …
911 results