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Herbal medicine for low-back pain.
Oltean H, Robbins C, van Tulder MW, Berman BM, Bombardier C, Gagnier JJ. Oltean H, et al. Cochrane Database Syst Rev. 2014 Dec 23;2014(12):CD004504. doi: 10.1002/14651858.CD004504.pub4. Cochrane Database Syst Rev. 2014. PMID: 25536022 Free PMC article. Review.
One trial (120 participants) examining Symphytum officinale L. (comfrey root extract) found low quality evidence that a Kytta-Salbe comfrey extract ointment is better than placebo ointment for short-term improvements in pain as assessed by VAS. ...
One trial (120 participants) examining Symphytum officinale L. (comfrey root extract) found low quality evidence that a Kytta- …
Comfrey root: from tradition to modern clinical trials.
Staiger C. Staiger C. Wien Med Wochenschr. 2013 Feb;163(3-4):58-64. doi: 10.1007/s10354-012-0162-4. Epub 2012 Dec 7. Wien Med Wochenschr. 2013. PMID: 23224633 Free PMC article. Review.
Comfrey root extract has been used for the topical treatment of painful muscle and joint complaints. ...This paper provides information on clinical trials, non-interventional studies and further literature published on comfrey root till date....
Comfrey root extract has been used for the topical treatment of painful muscle and joint complaints. ...This paper provides in …
Is comfrey root more than toxic pyrrolizidine alkaloids? Salvianolic acids among antioxidant polyphenols in comfrey (Symphytum officinale L.) roots.
Trifan A, Opitz SEW, Josuran R, Grubelnik A, Esslinger N, Peter S, Bräm S, Meier N, Wolfram E. Trifan A, et al. Food Chem Toxicol. 2018 Feb;112:178-187. doi: 10.1016/j.fct.2017.12.051. Epub 2017 Dec 28. Food Chem Toxicol. 2018. PMID: 29288756
Comfrey root preparations are used for the external treatment of joint distortions and myalgia, due to its analgesic and anti-inflammatory properties. Up to date, key activity-determining constituents of comfrey root extracts have not been completely e …
Comfrey root preparations are used for the external treatment of joint distortions and myalgia, due to its analgesic and anti- …
Comparative Assessment of Phytochemical Profiles of Comfrey (Symphytum officinale L.) Root Extracts Obtained by Different Extraction Techniques.
Nastić N, Borrás-Linares I, Lozano-Sánchez J, Švarc-Gajić J, Segura-Carretero A. Nastić N, et al. Molecules. 2020 Feb 14;25(4):837. doi: 10.3390/molecules25040837. Molecules. 2020. PMID: 32075048 Free PMC article.
In this work a comparative study on phytochemical profiles of comfrey root extracts obtained by different extraction approaches has been carried out. ...Hence, these results provided comprehensive approaches for treating comfrey root enriched in differ …
In this work a comparative study on phytochemical profiles of comfrey root extracts obtained by different extraction approache …
Globoidnan A, rabdosiin and globoidnan B as new phenolic markers in European-sourced comfrey (Symphytum officinale L.) root samples.
Trifan A, Wolfram E, Esslinger N, Grubelnik A, Skalicka-Woźniak K, Minceva M, Luca SV. Trifan A, et al. Phytochem Anal. 2021 Jul;32(4):482-494. doi: 10.1002/pca.2996. Epub 2020 Oct 5. Phytochem Anal. 2021. PMID: 33015885
OBJECTIVE: The aim of this study was to perform the qualitative and quantitative analysis of pyrrolizidine alkaloids (PAs) and phenolic compounds in the hydroethanolic extracts of 16 commercial comfrey root batches purchased from 12 different European countries. ... …
OBJECTIVE: The aim of this study was to perform the qualitative and quantitative analysis of pyrrolizidine alkaloids (PAs) and phenolic comp …
Comparative Study of the Biological Activity of Allantoin and Aqueous Extract of the Comfrey Root.
Savić VLj, Nikolić VD, Arsić IA, Stanojević LP, Najman SJ, Stojanović S, Mladenović-Ranisavljević II. Savić VLj, et al. Phytother Res. 2015 Aug;29(8):1117-22. doi: 10.1002/ptr.5356. Epub 2015 Apr 16. Phytother Res. 2015. PMID: 25880800
This study investigates the biological activity of pure allantoin (PA) and aqueous extract of the comfrey (Symphytum officinale L.) root (AECR) standardized to the allantoin content. ...Creams showed better effect on hydration and EI compared with the gels that cont …
This study investigates the biological activity of pure allantoin (PA) and aqueous extract of the comfrey (Symphytum officinale L.) …
Effect of a blend of comfrey root extract (Symphytum officinale L.) and tannic acid creams in the treatment of osteoarthritis of the knee: randomized, placebo-controlled, double-blind, multiclinical trials.
Smith DB, Jacobson BH. Smith DB, et al. J Chiropr Med. 2011 Sep;10(3):147-56. doi: 10.1016/j.jcm.2011.01.003. Epub 2011 Jul 22. J Chiropr Med. 2011. PMID: 22014903 Free PMC article.
The subjects were randomly assigned to 1 of 3 treatment groups: 10% or 20% comfrey root extract (Symphytum officinale L.) or a placebo cream. ...CONCLUSION: Both active topical comfrey formulations were effective in relieving pain and stiffness and in improvi …
The subjects were randomly assigned to 1 of 3 treatment groups: 10% or 20% comfrey root extract (Symphytum officinale L.) or a …
Efficacy of a comfrey root extract ointment in comparison to a diclofenac gel in the treatment of ankle distortions: results of an observer-blind, randomized, multicenter study.
Predel HG, Giannetti B, Koll R, Bulitta M, Staiger C. Predel HG, et al. Phytomedicine. 2005 Nov;12(10):707-14. doi: 10.1016/j.phymed.2005.06.001. Phytomedicine. 2005. PMID: 16323288 Clinical Trial.
In this study the primary variable was also to be validated prospectively. It was confirmatorily shown that Comfrey extract is non-inferior to diclofenac. The 95% confidence interval for the AUC (Comfrey extract minus Diclofenac gel) was 19.01-103.09h*N/cm2 and was …
In this study the primary variable was also to be validated prospectively. It was confirmatorily shown that Comfrey extract is non-in …
Efficacy and safety of comfrey root extract ointment in the treatment of acute upper or lower back pain: results of a double-blind, randomised, placebo controlled, multicentre trial.
Giannetti BM, Staiger C, Bulitta M, Predel HG. Giannetti BM, et al. Br J Sports Med. 2010 Jul;44(9):637-41. doi: 10.1136/bjsm.2009.058677. Epub 2009 May 21. Br J Sports Med. 2010. PMID: 19460762 Clinical Trial.
OBJECTIVE: The objective was to show the superiority of comfrey root extract ointment to placebo ointment in patients with acute upper or lower back pain. ...CONCLUSIONS: The results of this clinical trial were clear-cut and consistent across all primary and seconda …
OBJECTIVE: The objective was to show the superiority of comfrey root extract ointment to placebo ointment in patients with acu …
TLC densitometric method for screening of lycopsamine in comfrey root (Symphytum officinale L.) extracts using retrorsine as a reference compound.
Janeš D, Kreft S. Janeš D, et al. Acta Pharm. 2014 Dec;64(4):503-8. doi: 10.2478/acph-2014-0031. Acta Pharm. 2014. PMID: 25531790 Free article.
The idea of this research was to use retrorsine as a surrogate reference compound instead of lycopsamine reference or lycopsamine isolated from comfrey. A method for the analysis of lycopsamine in extracts of comfrey roots was developed and validated, employing thin …
The idea of this research was to use retrorsine as a surrogate reference compound instead of lycopsamine reference or lycopsamine isolated f …
33 results