Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

My NCBI Filters
Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1972 2
1973 2
1975 2
1976 2
1977 1
1978 4
1979 4
1980 4
1981 2
1982 2
1983 5
1984 3
1985 2
1986 2
1987 1
1988 1
1989 2
1990 3
1991 3
1992 1
1993 5
1994 1
1995 4
1996 3
1997 3
1998 1
1999 1
2000 5
2001 2
2002 3
2003 4
2004 2
2005 6
2006 1
2007 2
2008 7
2009 9
2010 5
2011 13
2012 8
2013 8
2014 4
2015 13
2016 9
2017 8
2018 3
2019 6
2020 5
2021 7
2022 4
2023 0
Text availability
Article attribute
Article type
Publication date

Search Results

188 results
Results by year
Filters applied: . Clear all
Page 1
Choosing a skeletal muscle relaxant.
See S, Ginzburg R. See S, et al. Am Fam Physician. 2008 Aug 1;78(3):365-70. Am Fam Physician. 2008. PMID: 18711953 Free article. Review.
Comparison studies have not shown one skeletal muscle relaxant to be superior to another. Cyclobenzaprine is the most heavily studied and has been shown to be effective for various musculoskeletal conditions. The sedative properties of tizanidine and cyclobenzaprine …
Comparison studies have not shown one skeletal muscle relaxant to be superior to another. Cyclobenzaprine is the most heavily studied …
Pharmacotherapy for Spine-Related Pain in Older Adults.
Fu JL, Perloff MD. Fu JL, et al. Drugs Aging. 2022 Jul;39(7):523-550. doi: 10.1007/s40266-022-00946-x. Epub 2022 Jun 27. Drugs Aging. 2022. PMID: 35754070 Review.
They should be used in lower doses with smaller dose adjustments. Some muscle relaxants (carisoprodol, chlorzoxazone, cyclobenzaprine, metaxalone, methocarbamol, and orphenadrine) are avoided in older adults due to risk for sedation and falls. ...
They should be used in lower doses with smaller dose adjustments. Some muscle relaxants (carisoprodol, chlorzoxazone, cyclobenzaprine …
Cyclobenzaprine for acute back pain.
Braschi E, Garrison S, Allan GM. Braschi E, et al. Can Fam Physician. 2015 Dec;61(12):1074. Can Fam Physician. 2015. PMID: 26668287 Free PMC article. Review. No abstract available.
The Skeletal Muscle Relaxer Cyclobenzaprine Is a Potent Non-Competitive Antagonist of Histamine H1 Receptors.
Singh K, Senatorov IS, Cheshmehkani A, Karmokar PF, Moniri NH. Singh K, et al. J Pharmacol Exp Ther. 2022 Mar;380(3):202-209. doi: 10.1124/jpet.121.000998. Epub 2022 Jan 6. J Pharmacol Exp Ther. 2022. PMID: 34992159
Based on this common adverse effect profile and the structural similarity of cyclobenzaprine to tricyclic antidepressants, as well as ethanolamine first-generation antihistamines, we hypothesized that cyclobenzaprine facilitates sedative effects via off-target antag …
Based on this common adverse effect profile and the structural similarity of cyclobenzaprine to tricyclic antidepressants, as well as …
The Relative Efficacy of Seven Skeletal Muscle Relaxants. An Analysis of Data From Randomized Studies.
Abril L, Zamora C, Cordero M, Williams AR, Friedman BW. Abril L, et al. J Emerg Med. 2022 Apr;62(4):455-461. doi: 10.1016/j.jemermed.2021.09.025. Epub 2022 Jan 20. J Emerg Med. 2022. PMID: 35067395
We compared the change in RMDQ among 8 groups: placebo, baclofen, metaxalone, tizanidine, diazepam, orphenadrine, methocarbamol, and cyclobenzaprine. All patients also received a nonsteroidal anti-inflammatory drug. ...Higher baseline RMDQ was associated with greater clini …
We compared the change in RMDQ among 8 groups: placebo, baclofen, metaxalone, tizanidine, diazepam, orphenadrine, methocarbamol, and cycl …
Cyclobenzaprine overdosage.
Ambre JJ. Ambre JJ. Ann Intern Med. 1985 Apr;102(4):559-60. doi: 10.7326/0003-4819-102-4-559_3. Ann Intern Med. 1985. PMID: 3977206 No abstract available.
Effect of cyclobenzaprine on tricyclic antidepressant assays.
Van Hoey NM. Van Hoey NM. Ann Pharmacother. 2005 Jul-Aug;39(7-8):1314-7. doi: 10.1345/aph.1E632. Epub 2005 Jun 14. Ann Pharmacother. 2005. PMID: 15956237 Review.
OBJECTIVE: To evaluate cyclobenzaprine interference on tricyclic antidepressant assays. DATA SOURCES: Literature was identified through a MEDLINE search (1966-August 2004) using the search terms cyclobenzaprine, tricyclic antidepressant, toxicology, and assay. ...Ol …
OBJECTIVE: To evaluate cyclobenzaprine interference on tricyclic antidepressant assays. DATA SOURCES: Literature was identified throu …
Cyclobenzaprine overdosage.
Linden CH, Mitchiner JC, Lindzon RD, Rumack BH. Linden CH, et al. J Toxicol Clin Toxicol. 1983 May;20(3):281-8. doi: 10.3109/15563658308990071. J Toxicol Clin Toxicol. 1983. PMID: 6620442
The clinical findings in three patients who ingested 260-900 mg cyclobenzaprine (Flexeril) consisted of delayed onset and long duration of anticholinergic symptomatology. ...The pharmacological properties of cyclobenzaprine may account for the observed toxicity....
The clinical findings in three patients who ingested 260-900 mg cyclobenzaprine (Flexeril) consisted of delayed onset and long durati …
Skin Permeation and Antinociception of Compounded Topical Cyclobenzaprine Hydrochloride Formulations.
Bryson E, Hartman R, Arnold J, Gorman G, Sweitzer S, Asbill S. Bryson E, et al. Int J Pharm Compd. 2015 Mar-Apr;19(2):161-6. Int J Pharm Compd. 2015. PMID: 26685496
In addition, cyclobenzaprine was tested in an in vivo formalin pain model. Cyclobenzaprine 5% compounded into all three bases yielded significant transdermal penetration and results in modest levels of cyclobenzaprine being retained in the skin tissue. System …
In addition, cyclobenzaprine was tested in an in vivo formalin pain model. Cyclobenzaprine 5% compounded into all three bases …
188 results