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Year Number of Results
1984 3
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1987 30
1988 14
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1990 36
1991 20
1992 60
1993 40
1994 26
1995 22
1996 55
1997 67
1998 87
1999 92
2000 127
2001 167
2002 148
2003 157
2004 184
2005 175
2006 177
2007 188
2008 161
2009 142
2010 161
2011 139
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2013 192
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2018 176
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2025 12

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4,320 results

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Page 1
Carvedilol as the new non-selective beta-blocker of choice in patients with cirrhosis and portal hypertension.
Turco L, Reiberger T, Vitale G, La Mura V. Turco L, et al. Liver Int. 2023 Jun;43(6):1183-1194. doi: 10.1111/liv.15559. Epub 2023 Apr 17. Liver Int. 2023. PMID: 36897563 Review.
In primary prophylaxis of variceal bleeding, carvedilol has been demonstrated to be more effective than endoscopic variceal ligation (EVL). ...The target dose of carvedilol to treat PH should be 12.5 mg/day. This review summarizes the evidence behind Baveno-VII reco …
In primary prophylaxis of variceal bleeding, carvedilol has been demonstrated to be more effective than endoscopic variceal ligation …
Carvedilol reduces the risk of decompensation and mortality in patients with compensated cirrhosis in a competing-risk meta-analysis.
Villanueva C, Torres F, Sarin SK, Shah HA, Tripathi D, Brujats A, Rodrigues SG, Bhardwaj A, Azam Z, Hayes PC, Jindal A, Abid S, Alvarado E, Bosch J; Carvedilol-IPD-MA-group and the Baveno Cooperation: an EASL Consortium. Villanueva C, et al. J Hepatol. 2022 Oct;77(4):1014-1025. doi: 10.1016/j.jhep.2022.05.021. Epub 2022 May 31. J Hepatol. 2022. PMID: 35661713 Free article.
The risk of death was also lower with carvedilol (SHR 0.417; 95% CI 0.194-0.896; p = 0.025; I(2) = 0.0%, Q-statistic-p = 0.989). CONCLUSIONS: Long-term carvedilol therapy reduced decompensation of cirrhosis and significantly improved survival in compensated patients …
The risk of death was also lower with carvedilol (SHR 0.417; 95% CI 0.194-0.896; p = 0.025; I(2) = 0.0%, Q-statistic-p = 0.989). CONC …
Carvedilol versus traditional, non-selective beta-blockers for adults with cirrhosis and gastroesophageal varices.
Zacharias AP, Jeyaraj R, Hobolth L, Bendtsen F, Gluud LL, Morgan MY. Zacharias AP, et al. Cochrane Database Syst Rev. 2018 Oct 29;10(10):CD011510. doi: 10.1002/14651858.CD011510.pub2. Cochrane Database Syst Rev. 2018. PMID: 30372514 Free PMC article. Review.
OBJECTIVES: To assess the beneficial and harmful effects of carvedilol compared with traditional, non-selective beta-blockers for adults with cirrhosis and gastroesophageal varices. ...AUTHORS' CONCLUSIONS: We found no clear beneficial or harmful effects of carvedilol
OBJECTIVES: To assess the beneficial and harmful effects of carvedilol compared with traditional, non-selective beta-blockers for adu …
Carvedilol Achieves Higher Hemodynamic Response and Lower Rebleeding Rates Than Propranolol in Secondary Prophylaxis.
Jachs M, Hartl L, Simbrunner B, Bauer D, Paternostro R, Balcar L, Hofer B, Pfisterer N, Schwarz M, Scheiner B, Stättermayer AF, Pinter M, Trauner M, Mandorfer M, Reiberger T. Jachs M, et al. Clin Gastroenterol Hepatol. 2023 Aug;21(9):2318-2326.e7. doi: 10.1016/j.cgh.2022.06.007. Epub 2022 Jul 14. Clin Gastroenterol Hepatol. 2023. PMID: 35842118 Free article.
Limited data exist on the efficacy of carvedilol in secondary prophylaxis of variceal bleeding. METHODS: Patients undergoing paired HVPG measurements for guiding secondary prophylaxis with either carvedilol or propranolol were included in this retrospective analysis …
Limited data exist on the efficacy of carvedilol in secondary prophylaxis of variceal bleeding. METHODS: Patients undergoing paired H …
How carvedilol does not activate beta(2)-adrenoceptors.
Lefkowitz RJ, Rockman HA, Shim PJ, Liu S, Ahn S, Pani B, Rajagopal S, Shenoy SK, Bouvier M, Benovic JL, Liggett SB, Ruffolo RR, Bristow MR, Packer M. Lefkowitz RJ, et al. Nat Commun. 2023 Nov 30;14(1):7866. doi: 10.1038/s41467-023-42848-5. Nat Commun. 2023. PMID: 38036531 Free PMC article. No abstract available.
Carvedilol attenuates liver fibrosis by suppressing autophagy and promoting apoptosis in hepatic stellate cells.
Meng D, Li Z, Wang G, Ling L, Wu Y, Zhang C. Meng D, et al. Biomed Pharmacother. 2018 Dec;108:1617-1627. doi: 10.1016/j.biopha.2018.10.005. Epub 2018 Oct 10. Biomed Pharmacother. 2018. PMID: 30372864 Free article.
Carvedilol has been identified as a promising agent for the treatment of liver fibrosis. ...Interestingly, the addition of chloroquine (CQ) failed to enhance the effects on GFP-LC3 puncta and LC3B-II levels, and carvedilol treatment resulted in a significant increas
Carvedilol has been identified as a promising agent for the treatment of liver fibrosis. ...Interestingly, the addition of chloroquin
Reply.
Chen WC, Hou MC. Chen WC, et al. Clin Gastroenterol Hepatol. 2019 Dec;17(13):2825. doi: 10.1016/j.cgh.2019.06.014. Clin Gastroenterol Hepatol. 2019. PMID: 31757367 No abstract available.
Improved Cardiac Performance and Decreased Arrhythmia in Hypertrophic Cardiomyopathy With Non-beta-Blocking R-Enantiomer Carvedilol.
Seo K, Yamamoto Y, Kirillova A, Kawana M, Yadav S, Huang Y, Wang Q, Lane KV, Pruitt BL, Perez MV, Bernstein D, Wu JC, Wheeler MT, Parikh VN, Ashley EA. Seo K, et al. Circulation. 2023 Nov 21;148(21):1691-1704. doi: 10.1161/CIRCULATIONAHA.123.065017. Epub 2023 Oct 18. Circulation. 2023. PMID: 37850394
In Myh6(R403Q/+) mice, R-carvedilol normalized hyperdynamic contraction, suppressed arrhythmia, and increased cardiac output better than metoprolol, verapamil, and mavacamten. The ability of R-carvedilol to suppress contractile function was well retained in MYH7(R40 …
In Myh6(R403Q/+) mice, R-carvedilol normalized hyperdynamic contraction, suppressed arrhythmia, and increased cardiac output better t …
How Carvedilol activates beta(2)-adrenoceptors.
Benkel T, Zimmermann M, Zeiner J, Bravo S, Merten N, Lim VJY, Matthees ESF, Drube J, Miess-Tanneberg E, Malan D, Szpakowska M, Monteleone S, Grimes J, Koszegi Z, Lanoiselée Y, O'Brien S, Pavlaki N, Dobberstein N, Inoue A, Nikolaev V, Calebiro D, Chevigné A, Sasse P, Schulz S, Hoffmann C, Kolb P, Waldhoer M, Simon K, Gomeza J, Kostenis E. Benkel T, et al. Nat Commun. 2022 Nov 19;13(1):7109. doi: 10.1038/s41467-022-34765-w. Nat Commun. 2022. PMID: 36402762 Free PMC article.
Carvedilol is among the most effective beta-blockers for improving survival after myocardial infarction. ...Here, we offer an alternative mechanism to rationalize carvedilol's cellular signalling. Using primary and immortalized cells genome-edited by CRISPR/C
Carvedilol is among the most effective beta-blockers for improving survival after myocardial infarction. ...Here, we offer an alterna
Long-term use of carvedilol in patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention.
Watanabe H, Ozasa N, Morimoto T, Shiomi H, Bingyuan B, Suwa S, Nakagawa Y, Izumi C, Kadota K, Ikeguchi S, Hibi K, Furukawa Y, Kaji S, Suzuki T, Akao M, Inada T, Hayashi Y, Nanasato M, Okutsu M, Kametani R, Sone T, Sugimura Y, Kawai K, Abe M, Kaneko H, Nakamura S, Kimura T; CAPITAL-RCT investigators. Watanabe H, et al. PLoS One. 2018 Aug 28;13(8):e0199347. doi: 10.1371/journal.pone.0199347. eCollection 2018. PLoS One. 2018. PMID: 30153268 Free PMC article. Clinical Trial.
Between August 2010 and May 2014, 801 patients were randomly assigned to the carvedilol group (N = 399) or the no beta-blocker group (N = 402) at 67 centers in Japan. ...TRIAL REGISTRATION: CAPITAL-RCT (Carvedilol Post-Intervention Long-Term Administration in Large- …
Between August 2010 and May 2014, 801 patients were randomly assigned to the carvedilol group (N = 399) or the no beta-blocker group …
4,320 results