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69 results

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A phase Ib/IIa clinical trial of dantrolene sodium in patients with Wolfram syndrome.
Abreu D, Stone SI, Pearson TS, Bucelli RC, Simpson AN, Hurst S, Brown CM, Kries K, Onwumere C, Gu H, Hoekel J, Tychsen L, Van Stavern GP, White NH, Marshall BA, Hershey T, Urano F. Abreu D, et al. JCI Insight. 2021 Aug 9;6(15):e145188. doi: 10.1172/jci.insight.145188. JCI Insight. 2021. PMID: 34185708 Free PMC article. Clinical Trial.
The primary objective was to assess the safety and tolerability of dantrolene sodium in adult and pediatric Wolfram syndrome patients. Secondary objectives were to evaluate the efficacy of dantrolene sodium on residual pancreatic beta cell functions, visual acuity, …
The primary objective was to assess the safety and tolerability of dantrolene sodium in adult and pediatric Wolfram syndrome patients …
A randomized, double-blind, placebo-controlled trial to evaluate the effect of nabiximols oromucosal spray on clinical measures of spasticity in patients with multiple sclerosis.
Bethoux FA, Farrell R, Checketts D, Sahr N, Berwaerts J, Alexander JK, Skobieranda F. Bethoux FA, et al. Mult Scler Relat Disord. 2024 Sep;89:105740. doi: 10.1016/j.msard.2024.105740. Epub 2024 Jun 20. Mult Scler Relat Disord. 2024. PMID: 39106541 Free article. Clinical Trial.
Patients had a diagnosis of MS and an untransformed MAS score of at least 2 in 2 of 6 LLMT-6 muscle groups despite current treatment with 1 of the following oral antispasticity agents: baclofen, tizanidine, or dantrolene. Eligible participants were randomly assigned to 1 …
Patients had a diagnosis of MS and an untransformed MAS score of at least 2 in 2 of 6 LLMT-6 muscle groups despite current treatment with …
Dantrolene sodium in traumatic muscle contracture: double-blind clinical and pharmacological trial.
Flacco L, Colozzi A, Ripari P, Pieralisi G. Flacco L, et al. Clin Ther. 1989 Sep-Oct;11(5):623-32. Clin Ther. 1989. PMID: 2680086 Clinical Trial.
This study showed that dantrolene sodium is useful in the treatment of traumatic contracture, and that it does not alter an individual's overall performance. Dantrolene sodium represents a valid treatment to accompany analgesic, anti-inflammatory, and rehabilitation …
This study showed that dantrolene sodium is useful in the treatment of traumatic contracture, and that it does not alter an individua …
Pharmacokinetic evaluation of oral dantrolene in the dog.
Haraschak JL, Langston VC, Wang R, Riggs C, Fellman C, Ross MK, Bulla C, Lunsford K, Mackin A, Archer T. Haraschak JL, et al. J Vet Pharmacol Ther. 2014 Jun;37(3):286-94. doi: 10.1111/jvp.12089. Epub 2013 Nov 13. J Vet Pharmacol Ther. 2014. PMID: 24219828 Free PMC article. Clinical Trial.
The pharmacokinetics of dantrolene and its active metabolite, 5-hydroxydantrolene, after a single oral dose of either 5 or 10 mg/kg of dantrolene was determined. ...While activated whole-blood expression of IL-2 and IFN-gamma as measured by qRT-PCR was markedly supp …
The pharmacokinetics of dantrolene and its active metabolite, 5-hydroxydantrolene, after a single oral dose of either 5 or 10 mg/kg o …
Efficacy of methylprednisolone pulse therapy on neuroleptic malignant syndrome in Parkinson's disease.
Sato Y, Asoh T, Metoki N, Satoh K. Sato Y, et al. J Neurol Neurosurg Psychiatry. 2003 May;74(5):574-6. doi: 10.1136/jnnp.74.5.574. J Neurol Neurosurg Psychiatry. 2003. Retraction in: J Neurol Neurosurg Psychiatry. 2018 Dec;89(12):e9. doi: 10.1136/jnnp.74.5.574ret. PMID: 12700295 Free PMC article. Retracted. Clinical Trial.
Both groups received levodopa, bromocriptine, and dantrolene. RESULTS: NMS in the steroid group healed within 10 days in 17 patients; median value of duration of illness of NMS in this group was 7 days (range 4-20). ...
Both groups received levodopa, bromocriptine, and dantrolene. RESULTS: NMS in the steroid group healed within 10 days in 17 patients; …
Dantrolene versus amiodarone for cardiopulmonary resuscitation: a randomized, double-blinded experimental study.
Wiesmann T, Freitag D, Dersch W, Eschbach D, Irqsusi M, Steinfeldt T, Wulf H, Feldmann C. Wiesmann T, et al. Sci Rep. 2017 Jan 18;7:40875. doi: 10.1038/srep40875. Sci Rep. 2017. PMID: 28098197 Free PMC article. Clinical Trial.
Hemodynamics were comparable in both dantrolene group amiodarone group after obtaining ROSC. Dantrolene and amiodarone had similar outcomes in our model of prolonged cardiac arrest, However, hemodynamic stability was not significantly improved using dantrolene …
Hemodynamics were comparable in both dantrolene group amiodarone group after obtaining ROSC. Dantrolene and amiodarone had sim …
Dantrolene in human malignant hyperthermia.
Kolb ME, Horne ML, Martz R. Kolb ME, et al. Anesthesiology. 1982 Apr;56(4):254-62. doi: 10.1097/00000542-198204000-00005. Anesthesiology. 1982. PMID: 7039419 Clinical Trial.
Four patients with unequivocal MH were treated with intravenous dantrolene more than 24 h after the diagnosis of MH; this delay in treatment of clinical signs in these patients, the mortality rate was 75 per cent, which is comparable to that reported without dantrolene …
Four patients with unequivocal MH were treated with intravenous dantrolene more than 24 h after the diagnosis of MH; this delay in tr …
Dantrolene sodium: a review of its pharmacological properties and therapeutic efficacy in spasticity.
Pinder RM, Brogden RN, Speight TM, Avery GS. Pinder RM, et al. Drugs. 1977 Jan;13(1):3-23. doi: 10.2165/00003495-197713010-00002. Drugs. 1977. PMID: 318989 Review.
Dantrolene sodium or dantrolene1 is 1([5-(nitrophenyl)furfurylidend] amino) hydantoin sodium hydrate. ...There has been a general clinical impression in controlled trials that dantrolene caused less sedation than would have been expected from therapeutically compara …
Dantrolene sodium or dantrolene1 is 1([5-(nitrophenyl)furfurylidend] amino) hydantoin sodium hydrate. ...There has been a general cli …
Treatment of spasticity with tizanidine in multiple sclerosis.
Lapierre Y, Bouchard S, Tansey C, Gendron D, Barkas WJ, Francis GS. Lapierre Y, et al. Can J Neurol Sci. 1987 Aug;14(3 Suppl):513-7. doi: 10.1017/s0317167100038026. Can J Neurol Sci. 1987. PMID: 3676923 Clinical Trial.
Current drugs used as antispastic agents include Dantrolene Sodium, Baclofen and Diazepam. Tizanidine (5-chloro-4-(2imidazolin-2 yl amino)-2,1,3-benzothialdiazole) is a new antispasticity agent that has purported central action. ...
Current drugs used as antispastic agents include Dantrolene Sodium, Baclofen and Diazepam. Tizanidine (5-chloro-4-(2imidazolin-2 yl a …
The novel rapid formulation of intravenous dantrolene (NPJ5008) versus standard dantrolene (Dantrium ): A clinical part-randomised phase 1 study in healthy volunteers.
Ng Kwet Shing RH, Clayton LB, Smith SL, Watson MJ, McKenzie LM, Chalmers DP, Whitaker G, Bilmen JG. Ng Kwet Shing RH, et al. Eur J Anaesthesiol. 2024 May 1;41(5):381-390. doi: 10.1097/EJA.0000000000001966. Epub 2024 Mar 5. Eur J Anaesthesiol. 2024. PMID: 38445365 Free PMC article. Clinical Trial.
NPJ5008 is a novel formulation of the indicated treatment, dantrolene sodium, developed to shorten preparation and administration times compared with the reference formulation Dantrium . ...OBJECTIVES: Assess bioequivalence of overall dantrolene (free acid) exposure …
NPJ5008 is a novel formulation of the indicated treatment, dantrolene sodium, developed to shorten preparation and administration tim …
69 results