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Neuromuscular junction innervation and motor function are preserved by restoring muscarinic signaling in perisynaptic glia in ALS.
Tremblay E, Arbour D, Vallée J, Piovesana R, Vallières G, Mechichi E, Robitaille R. Tremblay E, et al. iScience. 2026 Apr 9;29(5):115565. doi: 10.1016/j.isci.2026.115565. eCollection 2026 May 15. iScience. 2026. PMID: 42095090 Free PMC article.
Beginning at symptoms onset, SOD1 (G37R) mice received daily oral administration of darifenacin, a clinically approved type 3 muscarinic receptor antagonist, to reduce PSC hyperactivation. ...
Beginning at symptoms onset, SOD1 (G37R) mice received daily oral administration of darifenacin, a clinically approved type 3 muscari …
Gateways to clinical trials.
Moral MA, Tomillero A. Moral MA, et al. Methods Find Exp Clin Pharmacol. 2008 Mar;30(2):149-71. Methods Find Exp Clin Pharmacol. 2008. PMID: 18560631
This issue focuses on the following selection of drugs: 131-I-Chlorotoxin, 423557; Abatacept, Ad.Egr.TNF.11D, Adalimumab, AE-941, Ambrisentan, AMR-001, Anacetrapib, Anakinra, Aripiprazole, Atazanavir sulfate; BAY-639044, Bazedoxifene acetate, Belimumab, Bevacizumab, Bortez …
This issue focuses on the following selection of drugs: 131-I-Chlorotoxin, 423557; Abatacept, Ad.Egr.TNF.11D, Adalimumab, AE-941, Amb …