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408 results

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Page 1
Darifenacin.
[No authors listed] [No authors listed] 2023 Jul 12. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. 2023 Jul 12. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. PMID: 31644105 Free Books & Documents. Review.
Darifenacin is an anticholinergic and antispasmotic agent used to treat urinary incontinence and overactive bladder syndrome. Darifenacin has not been implicated in causing liver enzyme elevations or clinically apparent acute liver injury....
Darifenacin is an anticholinergic and antispasmotic agent used to treat urinary incontinence and overactive bladder syndrome. Dari …
Targeting acetylcholine signaling modulates persistent drug tolerance in EGFR-mutant lung cancer and impedes tumor relapse.
Nie M, Chen N, Pang H, Jiang T, Jiang W, Tian P, Yao L, Chen Y, DeBerardinis RJ, Li W, Yu Q, Zhou C, Hu Z. Nie M, et al. J Clin Invest. 2022 Oct 17;132(20):e160152. doi: 10.1172/JCI160152. J Clin Invest. 2022. PMID: 36048538 Free PMC article.
Strikingly, pharmacologically targeting ACh/M3R signaling with an FDA-approved drug, darifenacin, retarded tumor relapse in vivo. Mechanistically, upregulated ACh metabolism mediated drug tolerance in part through activating WNT signaling via ACh muscarinic receptor 3 (M3R …
Strikingly, pharmacologically targeting ACh/M3R signaling with an FDA-approved drug, darifenacin, retarded tumor relapse in vivo. Mec …
Comparative assessment of efficacy and safety of approved oral therapies for overactive bladder: a systematic review and network meta-analysis.
He W, Huang G, Cui W, Tian Y, Sun Q, Zhao X, Zhao Y, Li D, Liu X. He W, et al. Int Braz J Urol. 2023 Sep-Oct;49(5):535-563. doi: 10.1590/S1677-5538.IBJU.2023.0158. Int Braz J Urol. 2023. PMID: 37506033 Free PMC article.
Compared to placebo, imidafenacin 0.1mg showed a significantly increased incidence in hypertension, solifenacin 10mg in urinary tract infection, fesoterodine 4/8mg and darifenacin 15mg in headache. CONCLUSION: Solifenacin showed better efficacy. For safety, most anticholin …
Compared to placebo, imidafenacin 0.1mg showed a significantly increased incidence in hypertension, solifenacin 10mg in urinary tract infect …
Risk of dementia associated with anticholinergic drugs for overactive bladder in adults aged ≥55 years: nested case-control study.
Iyen B, Coupland C, Bell BG, Ashcroft DM, Orrell MW, Bishara D, Dening T, Avery AJ. Iyen B, et al. BMJ Med. 2024 Nov 12;3(1):e000799. doi: 10.1136/bmjmed-2023-000799. eCollection 2024. BMJ Med. 2024. PMID: 39574420 Free PMC article.
No significant increases in the risk of dementia associated with darifenacin, fesoterodine fumarate, flavoxate hydrochloride, propiverine hydrochloride, and trospium chloride were found. ...
No significant increases in the risk of dementia associated with darifenacin, fesoterodine fumarate, flavoxate hydrochloride, propive …
Increased nerve density adversely affects outcome in colorectal cancer and denervation suppresses tumor growth.
Wang H, Huo R, He K, Li W, Gao Y, He W, Yu M, Jiang SH, Xue J. Wang H, et al. J Transl Med. 2025 Jan 23;23(1):112. doi: 10.1186/s12967-025-06104-2. J Transl Med. 2025. PMID: 39849539 Free PMC article.
A murine chemical denervation model was employed to disrupt sympathetic nerves using 6-hydroxydopamine, inhibit muscarinic receptor 3 with darifenacin, and ablate sensory neurons with capsaicin. RESULTS: The total nerve density was 0.72 0.59/mm2, with intratumoral (0.42 …
A murine chemical denervation model was employed to disrupt sympathetic nerves using 6-hydroxydopamine, inhibit muscarinic receptor 3 with …
Darifenacin: Pharmacology and clinical usage.
Steers WD. Steers WD. Urol Clin North Am. 2006 Nov;33(4):475-82, viii. doi: 10.1016/j.ucl.2006.06.007. Urol Clin North Am. 2006. PMID: 17011383 Review.
Darifenacin is one of several recently approved antimuscarinics for the treatment of overactive bladder (OAB) and urge urinary incontinence. Darifenacin is an effective drug for the treatment of OAB and is tolerated by patients. Darifenacin's M3 selectivity i …
Darifenacin is one of several recently approved antimuscarinics for the treatment of overactive bladder (OAB) and urge urinary incont …
Drugs for overactive bladder.
[No authors listed] [No authors listed] Med Lett Drugs Ther. 2023 Mar 20;65(1672):41-45. doi: 10.58347/tml.2023.1672a. Med Lett Drugs Ther. 2023. PMID: 36897601 No abstract available.
Different interventions for preventing postoperative catheter-related bladder discomfort: a systematic review and meta-analysis.
Li S, Li P, Wang R, Li H. Li S, et al. Eur J Clin Pharmacol. 2022 Jun;78(6):897-906. doi: 10.1007/s00228-021-03251-5. Epub 2022 Feb 26. Eur J Clin Pharmacol. 2022. PMID: 35218404
There were insufficient trials to draw conclusions regarding atropine, butylscopolamine, chlorpheniramine, clonidine, darifenacin, diphenhydramine, glycopyrrolate, intravesical bupivacaine, ketamine-haloperidol, pethidine-haloperidol, ketorolac, lidocaine-prilocaine cream, …
There were insufficient trials to draw conclusions regarding atropine, butylscopolamine, chlorpheniramine, clonidine, darifenacin, di …
The clinical pharmacokinetics of darifenacin.
Skerjanec A. Skerjanec A. Clin Pharmacokinet. 2006;45(4):325-50. doi: 10.2165/00003088-200645040-00001. Clin Pharmacokinet. 2006. PMID: 16584282 Review.
The absolute bioavailability of darifenacin from 7.5 and 15 mg PR tablets was estimated to be 15.4% and 18.6%, respectively. ...Several possibly important drug-drug interactions have been identified with darifenacin, including ketoconazole, erythromycin and fluconaz …
The absolute bioavailability of darifenacin from 7.5 and 15 mg PR tablets was estimated to be 15.4% and 18.6%, respectively. ...Sever …
Drugs for benign prostatic hyperplasia.
[No authors listed] [No authors listed] Med Lett Drugs Ther. 2022 May 2;64(1649):65-69. Med Lett Drugs Ther. 2022. PMID: 35471226 No abstract available.
408 results