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Characterisation of the in vivo interactions between detomidine and methadone in horses: Pharmacokinetic and pharmacodynamic modelling.
Gozalo-Marcilla M, Luna SPL, Moreira da Silva R, Crosignani N, Lopes NP, Taylor PM, Pelligand L. Gozalo-Marcilla M, et al. Equine Vet J. 2019 Jul;51(4):517-529. doi: 10.1111/evj.13031. Epub 2018 Nov 17. Equine Vet J. 2019. PMID: 30298682 Free article.
RESULTS: Two and three compartment models best described the PK of detomidine and methadone, respectively. Detomidine decreased its own clearance as well as the clearance of methadone. ...MAIN LIMITATIONS: This is a small experimental study. CONCLUSIONS: Different P …
RESULTS: Two and three compartment models best described the PK of detomidine and methadone, respectively. Detomidine decrease …
Pharmacokinetic and pharmacodynamic analysis comparing diverse effects of detomidine, medetomidine, and dexmedetomidine in the horse: a population analysis.
Grimsrud KN, Ait-Oudhia S, Durbin-Johnson BP, Rocke DM, Mama KR, Rezende ML, Stanley SD, Jusko WJ. Grimsrud KN, et al. J Vet Pharmacol Ther. 2015 Feb;38(1):24-34. doi: 10.1111/jvp.12139. Epub 2014 Jul 29. J Vet Pharmacol Ther. 2015. PMID: 25073816 Free PMC article.
The present study characterizes the pharmacokinetic (PK) and pharmacodynamic (PD) relationships of the alpha2-adrenergic receptor agonists detomidine (DET), medetomidine (MED) and dexmedetomidine (DEX) in parallel groups of horses from in vivo data after single bolu …
The present study characterizes the pharmacokinetic (PK) and pharmacodynamic (PD) relationships of the alpha2-adrenergic receptor ago …
Effects of selective α2 -adrenergic receptor agonists on electrical field-stimulated contractions of isolated bronchi in horses.
Menozzi A, Pozzoli C, Poli E, Colla C, Placenza G, Bertini S. Menozzi A, et al. J Vet Pharmacol Ther. 2018 Apr;41(2):246-253. doi: 10.1111/jvp.12470. Epub 2017 Nov 21. J Vet Pharmacol Ther. 2018. PMID: 29164631
No effects were observed on the contraction induced by carbachol, while alpha(2) -AR agonists reduced EFS-evoked contractions in a concentration-related fashion. The rank order of potency (pD(2) ) was brimonidine (7.40 0.20) >medetomidine (7.09 0.24) >detomidi …
No effects were observed on the contraction induced by carbachol, while alpha(2) -AR agonists reduced EFS-evoked contractions in a concentra …