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Year Number of Results
1988 1
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12,236 results

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Page 1
Dexmedetomidine: present and future directions.
Lee S. Lee S. Korean J Anesthesiol. 2019 Aug;72(4):323-330. doi: 10.4097/kja.19259. Epub 2019 Jun 21. Korean J Anesthesiol. 2019. PMID: 31220910 Free PMC article. Review.
Dexmedetomidine may produce less delirium than other sedatives or even prevent delirium. The analgesic effect of dexmedetomidine is not strong; however, it can be administered as a useful analgesic adjuvant. ...Despite the lack of pediatric labelling, dexmedetomi …
Dexmedetomidine may produce less delirium than other sedatives or even prevent delirium. The analgesic effect of dexmedetomidine …
A systematic review of dexmedetomidine pharmacology in pediatric patients.
O'Kane A, Quinney SK, Kinney E, Bergstrom RF, Tillman EM. O'Kane A, et al. Clin Transl Sci. 2024 Dec;17(12):e70020. doi: 10.1111/cts.70020. Clin Transl Sci. 2024. PMID: 39644147 Free PMC article.
There is a critical need to identify factors that contribute to variation in metabolism, clearance, and downstream targets of dexmedetomidine so that individualized pediatric dosing regimens can be developed. This review is focused on dexmedetomidine pharmacokinetic …
There is a critical need to identify factors that contribute to variation in metabolism, clearance, and downstream targets of dexmedetomi …
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Jakob SM, Ruokonen E, Grounds RM, Sarapohja T, Garratt C, Pocock SJ, Bratty JR, Takala J; Dexmedetomidine for Long-Term Sedation Investigators. Jakob SM, et al. JAMA. 2012 Mar 21;307(11):1151-60. doi: 10.1001/jama.2012.304. JAMA. 2012. PMID: 22436955 Clinical Trial.
The MIDEX trial compared midazolam with dexmedetomidine in ICUs of 44 centers in 9 European countries; the PRODEX trial compared propofol with dexmedetomidine in 31 centers in 6 European countries and 2 centers in Russia. ...Time at target sedation was analyzed in p …
The MIDEX trial compared midazolam with dexmedetomidine in ICUs of 44 centers in 9 European countries; the PRODEX trial compared prop …
Dexmedetomidine in Palliative Care: A Versatile New Weapon Against Delirium and Pain-Systematic Review.
Tavares T, Almeida J, Gonçalves E, Abelha F. Tavares T, et al. J Palliat Med. 2024 Oct;27(10):1390-1403. doi: 10.1089/jpm.2023.0609. Epub 2024 May 21. J Palliat Med. 2024. PMID: 38770684
Current therapy is not satisfactory. Dexmedetomidine could be useful in the control of delirium and pain but is not approved outside of intensive care setting. ...This is the first systematic review of dexmedetomidine in palliative care. Quality evidence is limited, …
Current therapy is not satisfactory. Dexmedetomidine could be useful in the control of delirium and pain but is not approved outside …
Dexmedetomidine enables copper homeostasis in cerebral ischemia/reperfusion via ferredoxin 1.
Guo Q, Ma M, Yu H, Han Y, Zhang D. Guo Q, et al. Ann Med. 2023 Dec;55(1):2209735. doi: 10.1080/07853890.2023.2209735. Ann Med. 2023. PMID: 37162502 Free PMC article.
Excessive oxygen free radicals and toxic substances are generated in cerebral ischemia-reperfusion (I/R) process. Dexmedetomidine (DEX), a common anesthetic and sedative drug, can considerably boost glutathione (GSH), which has anti-copper influx effects. ...Together, cupr …
Excessive oxygen free radicals and toxic substances are generated in cerebral ischemia-reperfusion (I/R) process. Dexmedetomidine (DE …
Dexmedetomidine.
Bhana N, Goa KL, McClellan KJ. Bhana N, et al. Drugs. 2000 Feb;59(2):263-8; discussion 269-70. doi: 10.2165/00003495-200059020-00012. Drugs. 2000. PMID: 10730549
Dexmedetomidine is a potent alpha2-adrenoceptor agonist with 8 times higher affinity for the alpha2-adrenoceptor than clonidine. ...Dexmedetomidine was well tolerated in phase III studies. The most frequently observed adverse events were hypotension, bradycardia and …
Dexmedetomidine is a potent alpha2-adrenoceptor agonist with 8 times higher affinity for the alpha2-adrenoceptor than clonidine. ... …
Dexmedetomidine and Perioperative Arrhythmias.
Duan S, Zhou S. Duan S, et al. J Cardiothorac Vasc Anesth. 2024 May;38(5):1221-1227. doi: 10.1053/j.jvca.2024.01.006. Epub 2024 Jan 10. J Cardiothorac Vasc Anesth. 2024. PMID: 38443205 Review.
Several studies have indicated that dexmedetomidine may have a potential role in preventing and treating perioperative tachyarrhythmias. However, the specific effect and mechanism of action of dexmedetomidine in this context remain unclear. Dexmedetomidine is …
Several studies have indicated that dexmedetomidine may have a potential role in preventing and treating perioperative tachyarrhythmi …
[Dexmedetomidine].
Gerresheim G, Schwemmer U. Gerresheim G, et al. Anaesthesist. 2013 Aug;62(8):661-74. doi: 10.1007/s00101-013-2206-6. Anaesthesist. 2013. PMID: 23917892 Review. German.
Dexmedetomidine is a highly selective alpha2-receptor agonist with sedative, analgetic and anxiolytic effects. ...In this respect dexmedetomidine achieves the same desired effect as propofol and midazolam; however, in direct comparison to a sedation regime with benz …
Dexmedetomidine is a highly selective alpha2-receptor agonist with sedative, analgetic and anxiolytic effects. ...In this respect …
Dexmedetomidine: an update.
Zivadinovic J, Nikolic A, Jankovic R. Zivadinovic J, et al. Curr Opin Anaesthesiol. 2026 Aug 1;39(4):444-448. doi: 10.1097/ACO.0000000000001651. Epub 2026 Mar 31. Curr Opin Anaesthesiol. 2026. PMID: 42054174 Review.
PURPOSE OF REVIEW: Dexmedetomidine has evolved from a sedative adjunct to a multimodal perioperative adjunct with effects extending beyond hypnosis and analgesia. ...SUMMARY: Current evidence supports dexmedetomidine as a multimodal adjunct that enhances perioperati …
PURPOSE OF REVIEW: Dexmedetomidine has evolved from a sedative adjunct to a multimodal perioperative adjunct with effects extending b …
[Dexmedetomidine].
Sakaguchi Y, Takahashi S. Sakaguchi Y, et al. Masui. 2006 Jul;55(7):856-63. Masui. 2006. PMID: 16856546 Review. Japanese.
Dexmedetomidine, a potent and highly selective alpha2-agonist, provides a unique "conscious sedation" (patients appear to be asleep, but are readily roused), analgesia, without respiratory depression. ...The major problem with dexmedetomidine is its hemodynamic effe …
Dexmedetomidine, a potent and highly selective alpha2-agonist, provides a unique "conscious sedation" (patients appear to be asleep, …
12,236 results
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