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2,140 results

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Page 1
A Randomized Clinical Trial of Dexmedetomidine on Delirium, Cognitive Dysfunction, and Sleep After Non-Ambulatory Orthopedic Surgery With Regional Anesthesia.
Karageorgos V, Darivianaki P, Spartinou A, Christofaki M, Chatzimichali A, Nyktari V, Simos P, Papaioannou A. Karageorgos V, et al. Anesth Analg. 2026 Jan 1;142(1):102-113. doi: 10.1213/ANE.0000000000007548. Epub 2025 May 22. Anesth Analg. 2026. PMID: 40403182 Clinical Trial.
Assessments of all outcome variables were performed before surgery, and at 48 hours and 3 months postoperatively. RESULTS: A total of 80 patients (dexmedetomidine group n = 41) were enrolled in the study and completed the follow-up. POD, ED, and early POCD incidence were s …
Assessments of all outcome variables were performed before surgery, and at 48 hours and 3 months postoperatively. RESULTS: A total of 80 pat …
Effect of Dexmedetomidine on Mortality and Ventilator-Free Days in Patients Requiring Mechanical Ventilation With Sepsis: A Randomized Clinical Trial.
Kawazoe Y, Miyamoto K, Morimoto T, Yamamoto T, Fuke A, Hashimoto A, Koami H, Beppu S, Katayama Y, Itoh M, Ohta Y, Yamamura H; Dexmedetomidine for Sepsis in Intensive Care Unit Randomized Evaluation (DESIRE) Trial Investigators. Kawazoe Y, et al. JAMA. 2017 Apr 4;317(13):1321-1328. doi: 10.1001/jama.2017.2088. JAMA. 2017. PMID: 28322414 Free PMC article. Clinical Trial.
INTERVENTIONS: Patients were randomized to receive either sedation with dexmedetomidine (n = 100) or sedation without dexmedetomidine (control group; n = 101). Other agents used in both groups were fentanyl, propofol, and midazolam. ...Adverse events occurred in 8 ( …
INTERVENTIONS: Patients were randomized to receive either sedation with dexmedetomidine (n = 100) or sedation without dexmedetomid …
Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials.
Jakob SM, Ruokonen E, Grounds RM, Sarapohja T, Garratt C, Pocock SJ, Bratty JR, Takala J; Dexmedetomidine for Long-Term Sedation Investigators. Jakob SM, et al. JAMA. 2012 Mar 21;307(11):1151-60. doi: 10.1001/jama.2012.304. JAMA. 2012. PMID: 22436955 Clinical Trial.
The MIDEX trial compared midazolam with dexmedetomidine in ICUs of 44 centers in 9 European countries; the PRODEX trial compared propofol with dexmedetomidine in 31 centers in 6 European countries and 2 centers in Russia. ...Time at target sedation was analyzed in p …
The MIDEX trial compared midazolam with dexmedetomidine in ICUs of 44 centers in 9 European countries; the PRODEX trial compared prop …
Pre-operative dexmedetomidine nasal spray and emergence agitation in adults undergoing ear, nose and throat surgery: a randomised controlled trial.
Wang D, Dou W, Hu JH, Huang L, Liu H, Ji FH, Peng K. Wang D, et al. Anaesthesia. 2025 Dec;80(12):1519-1527. doi: 10.1111/anae.16726. Epub 2025 Aug 8. Anaesthesia. 2025. PMID: 40778580 Free article. Clinical Trial.
We hypothesised that pre-operative dexmedetomidine nasal spray would reduce the incidence of emergence agitation in adult patients undergoing these procedures. ...Patients were allocated (1:1) to receive nasal spray with dexmedetomidine (75-100 mug based on age and …
We hypothesised that pre-operative dexmedetomidine nasal spray would reduce the incidence of emergence agitation in adult patients un …
Low-Dose Nocturnal Dexmedetomidine Prevents ICU Delirium. A Randomized, Placebo-controlled Trial.
Skrobik Y, Duprey MS, Hill NS, Devlin JW. Skrobik Y, et al. Am J Respir Crit Care Med. 2018 May 1;197(9):1147-1156. doi: 10.1164/rccm.201710-1995OC. Am J Respir Crit Care Med. 2018. PMID: 29498534 Clinical Trial.
MEASUREMENTS AND MAIN RESULTS: Nocturnal dexmedetomidine (vs. placebo) was associated with a greater proportion of patients who remained delirium-free during the ICU stay (dexmedetomidine [40 (80%) of 50 patients] vs. placebo [27 (54%) of 50 patients]; relative risk …
MEASUREMENTS AND MAIN RESULTS: Nocturnal dexmedetomidine (vs. placebo) was associated with a greater proportion of patients who remai …
Dexmedetomidine Versus Midazolam for End-of-Life Sedation: The DREAMS Non-Blinded Randomized Clinical Trial.
Thomas B, Barclay G, Mansfield K, Mullan J, Lo WA. Thomas B, et al. J Pain Symptom Manage. 2025 Nov;70(5):459-469. doi: 10.1016/j.jpainsymman.2025.07.027. Epub 2025 Aug 25. J Pain Symptom Manage. 2025. PMID: 40769281 Clinical Trial.
Dexmedetomidine showed superior early delirium severity scores (day 1 MDAS: 6.5 vs. 8.8, P = 0.05) which did not persist. ...Dexmedetomidine patients experienced lower initial delirium severity scores and fewer early withdrawals in secondary analysis. ...
Dexmedetomidine showed superior early delirium severity scores (day 1 MDAS: 6.5 vs. 8.8, P = 0.05) which did not persist. ...Dexme …
Dexmedetomidine to Reduce Vasopressor Resistance in Refractory Septic Shock: alpha2 Agonist Dexmedetomidine for REfractory Septic Shock (ADRESS): A Double-Blind Randomized Controlled Pilot Trial.
Dargent A, Bourredjem A, Jacquier M, Bohe J, Argaud L, Levy B, Fournel I, Cransac A, Badie J, Quintin L, Quenot JP. Dargent A, et al. Crit Care Med. 2025 Apr 1;53(4):e884-e896. doi: 10.1097/CCM.0000000000006608. Epub 2025 Feb 28. Crit Care Med. 2025. PMID: 40019329 Free PMC article. Clinical Trial.
The alpha2 Agonist Dexmedetomidine for REfractory Septic Shock (ADRESS) pilot study aimed to evaluate the effect of dexmedetomidine on the vasopressor response in patients with refractory septic shock. ...However, heart rate was not decreased in the dexmedetomidi …
The alpha2 Agonist Dexmedetomidine for REfractory Septic Shock (ADRESS) pilot study aimed to evaluate the effect of dexmedetomidin …
Effects of dexmedetomidine administered at acupuncture point GV20 compared to intramuscular route in dogs.
Pons A, Canfrán S, Benito J, Cediel-Algovia R, Gómez de Segura IA. Pons A, et al. J Small Anim Pract. 2017 Jan;58(1):23-28. doi: 10.1111/jsap.12601. Epub 2016 Nov 14. J Small Anim Pract. 2017. PMID: 27859317 Clinical Trial.
OBJECTIVE: To compare the sedative effects produced by dexmedetomidine in dogs, administered either intramuscularly or into the Governing Vessel 20 acupuncture point. MATERIALS AND METHODS: Six dogs were sedated with 125 g/m(2) dexmedetomidine injected either intra …
OBJECTIVE: To compare the sedative effects produced by dexmedetomidine in dogs, administered either intramuscularly or into the Gover …
Mini-dose esketamine-dexmedetomidine combination to supplement analgesia for patients after scoliosis correction surgery: a double-blind randomised trial.
Zhang Y, Cui F, Ma JH, Wang DX. Zhang Y, et al. Br J Anaesth. 2023 Aug;131(2):385-396. doi: 10.1016/j.bja.2023.05.001. Epub 2023 Jun 9. Br J Anaesth. 2023. PMID: 37302963 Free article. Clinical Trial.
BACKGROUND: Patients often experience severe pain after scoliosis correction surgery. Esketamine and dexmedetomidine each improves analgesia but can produce side-effects. We therefore tested the hypothesis that a mini-dose esketamine-dexmedetomidine combination safe …
BACKGROUND: Patients often experience severe pain after scoliosis correction surgery. Esketamine and dexmedetomidine each improves an …
Dexmedetomidine for Reducing Mortality in Patients With Septic Shock: A Randomized Controlled Trial (DecatSepsis).
Ezz Al-Regal AR, Ramzy EA, Atia AAA, Emara MM. Ezz Al-Regal AR, et al. Chest. 2024 Dec;166(6):1394-1405. doi: 10.1016/j.chest.2024.06.3794. Epub 2024 Jul 14. Chest. 2024. PMID: 39004217 Clinical Trial.
Dexmedetomidine reduced the epinephrine infusion rescue (relative risk reduction, 0.6; 95% CI, 0.06-0.93; P = .025). ...INTERPRETATION: The study was underpowered to detect a reduction in in-hospital mortality or norepinephrine equivalent dose in patients with septic shock …
Dexmedetomidine reduced the epinephrine infusion rescue (relative risk reduction, 0.6; 95% CI, 0.06-0.93; P = .025). ...INTERPRETATIO …
2,140 results