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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1964 5
1965 6
1966 26
1967 27
1968 18
1969 30
1970 33
1971 34
1972 57
1973 80
1974 72
1975 68
1976 67
1977 73
1978 75
1979 68
1980 64
1981 71
1982 88
1983 80
1984 79
1985 76
1986 91
1987 88
1988 86
1989 89
1990 75
1991 72
1992 70
1993 56
1994 66
1995 81
1996 45
1997 52
1998 59
1999 44
2000 34
2001 30
2002 42
2003 36
2004 43
2005 53
2006 46
2007 46
2008 32
2009 33
2010 38
2011 32
2012 25
2013 28
2014 28
2015 21
2016 26
2017 26
2018 16
2019 7
2020 9
2021 10
2022 0
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Search Results

2,771 results
Results by year
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Page 1
Bioavailability and safety of diazepam intranasal solution compared to oral and rectal diazepam in healthy volunteers.
Hogan RE, Gidal BE, Koplowitz B, Koplowitz LP, Lowenthal RE, Carrazana E. Hogan RE, et al. Epilepsia. 2020 Mar;61(3):455-464. doi: 10.1111/epi.16449. Epub 2020 Feb 17. Epilepsia. 2020. PMID: 32065672 Free PMC article. Clinical Trial.
OBJECTIVE: The study assesses the bioavailability of diazepam after intranasal administration (diazepam nasal spray) in healthy volunteers. ...The t(max) (time to reach maximum plasma concentration) was similar for diazepam nasal spray and diazepam rec …
OBJECTIVE: The study assesses the bioavailability of diazepam after intranasal administration (diazepam nasal spray) in health …
Pharmacokinetics and pharmacodynamics of oral diazepam: effect of dose, plasma concentration, and time.
Friedman H, Greenblatt DJ, Peters GR, Metzler CM, Charlton MD, Harmatz JS, Antal EJ, Sanborn EC, Francom SF. Friedman H, et al. Clin Pharmacol Ther. 1992 Aug;52(2):139-50. doi: 10.1038/clpt.1992.123. Clin Pharmacol Ther. 1992. PMID: 1505149 Clinical Trial.
Eleven healthy subjects received single oral doses of placebo, 2 mg diazepam, 5 mg diazepam, and 10 mg diazepam in a randomized four-way crossover study. ...The percentage of EEG amplitude falling in the 13 to 31 Hz range did not change over baseline with pla …
Eleven healthy subjects received single oral doses of placebo, 2 mg diazepam, 5 mg diazepam, and 10 mg diazepam in a ra …
Intranasal Midazolam versus Rectal Diazepam for the Management of Canine Status Epilepticus: A Multicenter Randomized Parallel-Group Clinical Trial.
Charalambous M, Bhatti SFM, Van Ham L, Platt S, Jeffery ND, Tipold A, Siedenburg J, Volk HA, Hasegawa D, Gallucci A, Gandini G, Musteata M, Ives E, Vanhaesebrouck AE. Charalambous M, et al. J Vet Intern Med. 2017 Jul;31(4):1149-1158. doi: 10.1111/jvim.14734. Epub 2017 May 24. J Vet Intern Med. 2017. PMID: 28543780 Free PMC article. Clinical Trial.
OBJECTIVE: To evaluate the clinical efficacy of intranasal midazolam (IN-MDZ), via a mucosal atomization device, as a first-line management option for canine status epilepticus and compare it to rectal administration of diazepam (R-DZP) for controlling status epilepticus b …
OBJECTIVE: To evaluate the clinical efficacy of intranasal midazolam (IN-MDZ), via a mucosal atomization device, as a first-line management …
A clinical trial of single dose rectal and oral administration of diazepam for the prevention of serial seizures in adult epileptic patients.
Milligan NM, Dhillon S, Griffiths A, Oxley J, Richens A. Milligan NM, et al. J Neurol Neurosurg Psychiatry. 1984 Mar;47(3):235-40. doi: 10.1136/jnnp.47.3.235. J Neurol Neurosurg Psychiatry. 1984. PMID: 6368753 Free PMC article. Clinical Trial.
Pharmacokinetic studies revealed a wide range of serum diazepam concentrations 60 min after administration of the suppository (mean serum diazepam level 190 +/- 73 (SD ng/ml). In a similar study oral administration of diazepam 20 mg significantly reduced the …
Pharmacokinetic studies revealed a wide range of serum diazepam concentrations 60 min after administration of the suppository (mean s …
Rheumatology.
Scott WA. Scott WA. S Afr Med J. 1973 Apr 7;47(13):551. S Afr Med J. 1973. PMID: 4540458 Clinical Trial. No abstract available.
Comparing Diazepam Plus Fentanyl With Midazolam Plus Fentanyl in the Moderate Procedural Sedation of Anterior Shoulder Dislocations: A Randomized Clinical Trial.
Afzalimoghaddam M, Khademi MF, Mirfazaelian H, Payandemehr P, Karimialavijeh E, Jalali A. Afzalimoghaddam M, et al. J Emerg Med. 2021 Jan;60(1):1-7. doi: 10.1016/j.jemermed.2020.09.030. Epub 2020 Oct 21. J Emerg Med. 2021. PMID: 33097351 Clinical Trial.
The mean standard deviation time of the onset of the muscle relaxation and time taken to reduction was shorter in the diazepam plus fentanyl group (p = 0.016 and p = 0.001, respectively). ...The overall satisfaction of patients and physicians was higher in the diazepam
The mean standard deviation time of the onset of the muscle relaxation and time taken to reduction was shorter in the diazepam plus f …
Pharmacokinetics and safety of VALTOCO (NRL-1; diazepam nasal spray) in patients with epilepsy during seizure (ictal/peri-ictal) and nonseizure (interictal) conditions: A phase 1, open-label study.
Hogan RE, Tarquinio D, Sperling MR, Klein P, Miller I, Segal EB, Rabinowicz AL, Carrazana E. Hogan RE, et al. Epilepsia. 2020 May;61(5):935-943. doi: 10.1111/epi.16506. Epub 2020 Apr 27. Epilepsia. 2020. PMID: 32338380 Free PMC article. Clinical Trial.
SIGNIFICANCE: The epileptic conditions (ictal/peri-ictal, interictal) had minimal impact on diazepam nasal spray pharmacokinetics in patients with epilepsy. Therefore, diazepam nasal spray can be administered ictally and interictally. Diazepam nasal spray saf …
SIGNIFICANCE: The epileptic conditions (ictal/peri-ictal, interictal) had minimal impact on diazepam nasal spray pharmacokinetics in …
Evaluation of Pharmacokinetics and Dose Proportionality of Diazepam After Intranasal Administration of NRL-1 to Healthy Volunteers.
Tanimoto S, Pesco Koplowitz L, Lowenthal RE, Koplowitz B, Rabinowicz AL, Carrazana E. Tanimoto S, et al. Clin Pharmacol Drug Dev. 2020 Aug;9(6):719-727. doi: 10.1002/cpdd.767. Epub 2020 Jan 9. Clin Pharmacol Drug Dev. 2020. PMID: 31916704 Free PMC article. Clinical Trial.
NRL-1 is a novel intranasal formulation of diazepam that is being evaluated as rescue medication in patients with epilepsy who experience bouts of increased seizure activity despite stable regimens of antiepileptic drugs. ...Treatment-emergent adverse events were consisten …
NRL-1 is a novel intranasal formulation of diazepam that is being evaluated as rescue medication in patients with epilepsy who experi …
Comparative clinical trial of diazepam with other conventional drugs in tetanus.
Vassa NT, Doshi HV, Yajnik VH, Shah SS, Joshi KR, Patel SH. Vassa NT, et al. Postgrad Med J. 1974 Dec;50(590):755-8. doi: 10.1136/pgmj.50.590.755. Postgrad Med J. 1974. PMID: 4619836 Free PMC article. Clinical Trial.
Results of therapeutic trial of diazepam in tetanus are presented. The trial included 200 cases of tetanus-167 non-neonates and thirty-three neonates. ...The cases of group I received standard treatment while the cases of group II received diazepam in addition. Over …
Results of therapeutic trial of diazepam in tetanus are presented. The trial included 200 cases of tetanus-167 non-neonates and thirt …
Clinical importance of the interaction of diazepam and cimetidine.
Greenblatt DJ, Abernethy DR, Morse DS, Harmatz JS, Shader RI. Greenblatt DJ, et al. N Engl J Med. 1984 Jun 21;310(25):1639-43. doi: 10.1056/NEJM198406213102505. N Engl J Med. 1984. PMID: 6427609 Clinical Trial.
Cimetidine is known to impair the hepatic microsomal oxidation of diazepam, reducing its clearance and prolonging its half-life. We studied the clinical importance of this effect in 10 patients, who were receiving long-term treatment with diazepam for anxiety, tensi …
Cimetidine is known to impair the hepatic microsomal oxidation of diazepam, reducing its clearance and prolonging its half-life. We s …
2,771 results