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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1964 5
1965 6
1966 26
1967 27
1968 18
1969 30
1970 33
1971 34
1972 57
1973 80
1974 72
1975 68
1976 67
1977 73
1978 75
1979 68
1980 64
1981 71
1982 88
1983 80
1984 79
1985 76
1986 91
1987 88
1988 86
1989 89
1990 75
1991 72
1992 70
1993 56
1994 66
1995 81
1996 45
1997 52
1998 59
1999 44
2000 34
2001 30
2002 42
2003 36
2004 43
2005 53
2006 46
2007 46
2008 32
2009 33
2010 38
2011 32
2012 25
2013 28
2014 28
2015 21
2016 26
2017 26
2018 16
2019 7
2020 10
2021 17
2022 16
2023 5

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2,794 results

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Page 1
Pharmacokinetics and pharmacodynamics of oral diazepam: effect of dose, plasma concentration, and time.
Friedman H, Greenblatt DJ, Peters GR, Metzler CM, Charlton MD, Harmatz JS, Antal EJ, Sanborn EC, Francom SF. Friedman H, et al. Clin Pharmacol Ther. 1992 Aug;52(2):139-50. doi: 10.1038/clpt.1992.123. Clin Pharmacol Ther. 1992. PMID: 1505149 Clinical Trial.
Eleven healthy subjects received single oral doses of placebo, 2 mg diazepam, 5 mg diazepam, and 10 mg diazepam in a randomized four-way crossover study. ...The percentage of EEG amplitude falling in the 13 to 31 Hz range did not change over baseline with pla …
Eleven healthy subjects received single oral doses of placebo, 2 mg diazepam, 5 mg diazepam, and 10 mg diazepam in a ra …
Comparison of the actions of diazepam and lorazepam.
Dundee JW, McGowan WA, Lilburn JK, McKay AC, Hegarty JE. Dundee JW, et al. Br J Anaesth. 1979 May;51(5):439-46. doi: 10.1093/bja/51.5.439. Br J Anaesth. 1979. PMID: 36117 Free article. Clinical Trial.
Diazepam and lorazepam differ in potency and in the time-course of their action. As a sedative, diazepam 10 mg is equivalent to lorazepam 2-2.5 mg. Diazepam is better absorbed after oral than after i.m. administrations but this does not apply to lorazepam. .. …
Diazepam and lorazepam differ in potency and in the time-course of their action. As a sedative, diazepam 10 mg is equivalent t …
Bioavailability and safety of diazepam intranasal solution compared to oral and rectal diazepam in healthy volunteers.
Hogan RE, Gidal BE, Koplowitz B, Koplowitz LP, Lowenthal RE, Carrazana E. Hogan RE, et al. Epilepsia. 2020 Mar;61(3):455-464. doi: 10.1111/epi.16449. Epub 2020 Feb 17. Epilepsia. 2020. PMID: 32065672 Free PMC article. Clinical Trial.
OBJECTIVE: The study assesses the bioavailability of diazepam after intranasal administration (diazepam nasal spray) in healthy volunteers. ...The t(max) (time to reach maximum plasma concentration) was similar for diazepam nasal spray and diazepam rec …
OBJECTIVE: The study assesses the bioavailability of diazepam after intranasal administration (diazepam nasal spray) in health …
Intranasal Midazolam versus Rectal Diazepam for the Management of Canine Status Epilepticus: A Multicenter Randomized Parallel-Group Clinical Trial.
Charalambous M, Bhatti SFM, Van Ham L, Platt S, Jeffery ND, Tipold A, Siedenburg J, Volk HA, Hasegawa D, Gallucci A, Gandini G, Musteata M, Ives E, Vanhaesebrouck AE. Charalambous M, et al. J Vet Intern Med. 2017 Jul;31(4):1149-1158. doi: 10.1111/jvim.14734. Epub 2017 May 24. J Vet Intern Med. 2017. PMID: 28543780 Free PMC article. Clinical Trial.
OBJECTIVE: To evaluate the clinical efficacy of intranasal midazolam (IN-MDZ), via a mucosal atomization device, as a first-line management option for canine status epilepticus and compare it to rectal administration of diazepam (R-DZP) for controlling status epilepticus b …
OBJECTIVE: To evaluate the clinical efficacy of intranasal midazolam (IN-MDZ), via a mucosal atomization device, as a first-line management …
A clinical trial of single dose rectal and oral administration of diazepam for the prevention of serial seizures in adult epileptic patients.
Milligan NM, Dhillon S, Griffiths A, Oxley J, Richens A. Milligan NM, et al. J Neurol Neurosurg Psychiatry. 1984 Mar;47(3):235-40. doi: 10.1136/jnnp.47.3.235. J Neurol Neurosurg Psychiatry. 1984. PMID: 6368753 Free PMC article. Clinical Trial.
Pharmacokinetic studies revealed a wide range of serum diazepam concentrations 60 min after administration of the suppository (mean serum diazepam level 190 +/- 73 (SD ng/ml). In a similar study oral administration of diazepam 20 mg significantly reduced the …
Pharmacokinetic studies revealed a wide range of serum diazepam concentrations 60 min after administration of the suppository (mean s …
Diazepam and methadone blood levels following concurrent administration of diazepam and methadone.
Preston KL, Griffiths RR, Cone EJ, Darwin WD, Gorodetzky CW. Preston KL, et al. Drug Alcohol Depend. 1986 Oct;18(2):195-202. doi: 10.1016/0376-8716(86)90051-7. Drug Alcohol Depend. 1986. PMID: 3096681 Clinical Trial.
Results of a previous study indicated that the opioid effects of methadone were enhanced by the concurrent administration of diazepam in methadone-maintained subjects. To determine whether a pharmacokinetic interaction might account for this methadone-diazepam inter …
Results of a previous study indicated that the opioid effects of methadone were enhanced by the concurrent administration of diazepam …
A comparison of the clinical and psychological effects of diazepam and amylobarbitone in anxious patients.
Tansella CZ, Tansella M, Lader M. Tansella CZ, et al. Br J Clin Pharmacol. 1979 Jun;7(6):605-11. doi: 10.1111/j.1365-2125.1979.tb04650.x. Br J Clin Pharmacol. 1979. PMID: 380615 Free PMC article. Clinical Trial.
1. Twenty-four anxious inpatients were treated with diazepam, amylobarbitone sodium and placebo in flexible dosage for 1 week. ...The clinical and the psychological effects of the drugs were assessed by the comprehensive battery of psychiatrist's ratings, subjective …
1. Twenty-four anxious inpatients were treated with diazepam, amylobarbitone sodium and placebo in flexible dosage for 1 week. ...The …
Clinical importance of the interaction of diazepam and cimetidine.
Greenblatt DJ, Abernethy DR, Morse DS, Harmatz JS, Shader RI. Greenblatt DJ, et al. N Engl J Med. 1984 Jun 21;310(25):1639-43. doi: 10.1056/NEJM198406213102505. N Engl J Med. 1984. PMID: 6427609 Clinical Trial.
Cimetidine is known to impair the hepatic microsomal oxidation of diazepam, reducing its clearance and prolonging its half-life. We studied the clinical importance of this effect in 10 patients, who were receiving long-term treatment with diazepam for anxiety, tensi …
Cimetidine is known to impair the hepatic microsomal oxidation of diazepam, reducing its clearance and prolonging its half-life. We s …
Gepirone and diazepam in generalized anxiety disorder: a placebo-controlled trial.
Rickels K, Schweizer E, DeMartinis N, Mandos L, Mercer C. Rickels K, et al. J Clin Psychopharmacol. 1997 Aug;17(4):272-7. doi: 10.1097/00004714-199708000-00006. J Clin Psychopharmacol. 1997. PMID: 9241006 Clinical Trial.
This randomized, double-blind clinical trial involving 198 generalized anxiety disorder (GAD) patients was conducted to more clearly define gepirone's role for the treatment of anxiety in daily dosages of 10 to 45 mg compared with diazepam and placebo. ...The major …
This randomized, double-blind clinical trial involving 198 generalized anxiety disorder (GAD) patients was conducted to more clearly define …
Actions and interactions of indomethacin and diazepam on performance in healthy volunteers.
Nuotto E, Saarialho-Kere U. Nuotto E, et al. Pharmacol Toxicol. 1988 May;62(5):293-7. doi: 10.1111/j.1600-0773.1988.tb01890.x. Pharmacol Toxicol. 1988. PMID: 3045792 Clinical Trial.
Objective and subjective effects on performance of single oral doses of indomethacin (IM) 50 mg and 100 mg and diazepam (DZ) 10-15 mg, alone and in combination, were investigated in two double-blind studies conducted with parallel groups of healthy drug-naive student volun …
Objective and subjective effects on performance of single oral doses of indomethacin (IM) 50 mg and 100 mg and diazepam (DZ) 10-15 mg …
2,794 results