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Year Number of Results
1956 1
1975 8
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1977 38
1978 45
1979 46
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1981 49
1982 48
1983 56
1984 63
1985 95
1986 93
1987 91
1988 111
1989 129
1990 145
1991 148
1992 146
1993 209
1994 189
1995 217
1996 225
1997 231
1998 245
1999 277
2000 274
2001 319
2002 348
2003 377
2004 439
2005 420
2006 477
2007 497
2008 490
2009 505
2010 590
2011 593
2012 631
2013 708
2014 728
2015 729
2016 786
2017 760
2018 764
2019 768
2020 841
2021 211
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13,685 results
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Page 1
Diclofenac: an update on its mechanism of action and safety profile.
Gan TJ. Gan TJ. Curr Med Res Opin. 2010 Jul;26(7):1715-31. doi: 10.1185/03007995.2010.486301. Curr Med Res Opin. 2010. PMID: 20470236 Review.
As with all NSAIDs, diclofenac exerts its action via inhibition of prostaglandin synthesis by inhibiting cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) with relative equipotency. ...The diversity in diclofenac's MOA may suggest the potential for a relatively …
As with all NSAIDs, diclofenac exerts its action via inhibition of prostaglandin synthesis by inhibiting cyclooxygenase-1 (COX-1) and …
Oral Versus Topical Diclofenac Sodium in the Treatment of Osteoarthritis.
Tieppo Francio V, Davani S, Towery C, Brown TL. Tieppo Francio V, et al. J Pain Palliat Care Pharmacother. 2017 Jun;31(2):113-120. doi: 10.1080/15360288.2017.1301616. Epub 2017 Apr 7. J Pain Palliat Care Pharmacother. 2017. PMID: 28388238 Review.
Generally, oral NSAIDs are well tolerated; however our narrative review suggests that the topical solution had a better tolerability property than oral Diclofenac sodium, especially due to side effects of gastrointestinal bleeding with the utilization of the oral format. . …
Generally, oral NSAIDs are well tolerated; however our narrative review suggests that the topical solution had a better tolerability propert …
Diclofenac sodium.
Small RE. Small RE. Clin Pharm. 1989 Aug;8(8):545-58. Clin Pharm. 1989. PMID: 2670397 Review.
Diclofenac was as effective as indomethacin or sulindac in treating ankylosing spondylitis. The most frequent adverse effects reported for diclofenac were gastrointestinal, but these effects were fewer and less serious than occurred with aspirin or indomethacin; in
Diclofenac was as effective as indomethacin or sulindac in treating ankylosing spondylitis. The most frequent adverse effects reporte
Lumiracoxib.
Buvanendran A, Barkin R. Buvanendran A, et al. Drugs Today (Barc). 2007 Mar;43(3):137-47. doi: 10.1358/dot.2007.43.3.1062673. Drugs Today (Barc). 2007. PMID: 17380211 Review.
Diclofenac.
Ogle C. Ogle C. Conn Med. 1989 Oct;53(10):603-4. Conn Med. 1989. PMID: 2684502 Clinical Trial.
Diclofenac is the newest NSAID to be introduced to the United States. Extensive worldwide clinical studies with diclofenac have demonstrated its efficacy in the treatment of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. ...
Diclofenac is the newest NSAID to be introduced to the United States. Extensive worldwide clinical studies with diclofenac hav
Formation of a Toxic Quinoneimine Metabolite from Diclofenac: A Quantum Chemical Study.
Ramesh M, Bharatam PV. Ramesh M, et al. Drug Metab Lett. 2019;13(1):64-76. doi: 10.2174/1872312812666180913120736. Drug Metab Lett. 2019. PMID: 30210009
BACKGROUND: Diclofenac is a non-steroidal antiinflammatory drug. It is predominantly metabolized by CYP2C9. 4'-hydroxydiclofenac and its quinoneimine are the metabolites of diclofenac. ...Quinoneimine is an over-oxidized metabolite of diclofenac. METHOD: In t …
BACKGROUND: Diclofenac is a non-steroidal antiinflammatory drug. It is predominantly metabolized by CYP2C9. 4'-hydroxydiclofenac and …
Adsorption site-dependent transport of diclofenac in water saturated minerals and reference soils.
Yu C, Bi E. Yu C, et al. Chemosphere. 2019 Dec;236:124256. doi: 10.1016/j.chemosphere.2019.06.226. Epub 2019 Jul 1. Chemosphere. 2019. PMID: 31319305
Use of reclaimed water for irrigation is a main way for pharmaceutical compounds such as diclofenac getting into the soil environment. However, the role of minerals, especially iron oxides, in the diclofenac adsorption to soils with low soil organic matter (SOM) is …
Use of reclaimed water for irrigation is a main way for pharmaceutical compounds such as diclofenac getting into the soil environment …
Diclofenac removal by pyrite-Fenton process: Performance in batch and fixed-bed continuous flow systems.
Oral O, Kantar C. Oral O, et al. Sci Total Environ. 2019 May 10;664:817-823. doi: 10.1016/j.scitotenv.2019.02.084. Epub 2019 Feb 6. Sci Total Environ. 2019. PMID: 30769305
Batch experiments show that diclofenac removal increased with increasing hydrogen peroxide and pyrite concentration. ...Batch results showed a direct correlation between the rate of diclofenac degradation and the rate of iron dissolution from pyrite, suggesting that …
Batch experiments show that diclofenac removal increased with increasing hydrogen peroxide and pyrite concentration. ...Batch results …
Single-dose diclofenac in healthy volunteers can cause decrease in renal perfusion measured by functional magnetic resonance imaging.
Hellms S, Gueler F, Gutberlet M, Schebb NH, Rund K, Kielstein JT, VoChieu V, Rauhut S, Greite R, Martirosian P, Haller H, Wacker F, Derlin K. Hellms S, et al. J Pharm Pharmacol. 2019 Aug;71(8):1262-1270. doi: 10.1111/jphp.13105. Epub 2019 May 27. J Pharm Pharmacol. 2019. PMID: 31131893
Topical diclofenac application did not result in relevant systemic diclofenac levels (range 5-75 nm). ...CONCLUSIONS: Single-dose diclofenac caused a decrease in renal perfusion in participants with diclofenac levels 225 nm. ...
Topical diclofenac application did not result in relevant systemic diclofenac levels (range 5-75 nm). ...CONCLUSIONS: Single-d …
[Lumiracoxib--Prexigem].
Duh D, Vandevijver A. Duh D, et al. J Pharm Belg. 2007;62(3):95-6. J Pharm Belg. 2007. PMID: 17955960 French. No abstract available.
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