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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1975 3
1976 4
1977 10
1978 20
1979 21
1980 12
1981 18
1982 13
1983 14
1984 19
1985 19
1986 27
1987 22
1988 25
1989 36
1990 45
1991 41
1992 50
1993 70
1994 55
1995 55
1996 76
1997 65
1998 65
1999 62
2000 69
2001 59
2002 72
2003 58
2004 97
2005 89
2006 79
2007 80
2008 72
2009 85
2010 87
2011 82
2012 77
2013 80
2014 70
2015 78
2016 75
2017 72
2018 45
2019 41
2020 38
2021 33
2022 31
2023 23
2024 16

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2,295 results

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Page 1
Safety and efficacy of curcumin versus diclofenac in knee osteoarthritis: a randomized open-label parallel-arm study.
Shep D, Khanwelkar C, Gade P, Karad S. Shep D, et al. Trials. 2019 Apr 11;20(1):214. doi: 10.1186/s13063-019-3327-2. Trials. 2019. PMID: 30975196 Free PMC article. Clinical Trial.
RESULTS: At days 14 and 28, patients receiving curcumin showed similar improvement in severity of pain and KOOS scale when compared with diclofenac, and the difference was not statistically significant. At day 7, the patients who received curcumin experienced a significant …
RESULTS: At days 14 and 28, patients receiving curcumin showed similar improvement in severity of pain and KOOS scale when compared with …
Diclofenac.
Ogle C. Ogle C. Conn Med. 1989 Oct;53(10):603-4. Conn Med. 1989. PMID: 2684502 Clinical Trial.
Diclofenac is the newest NSAID to be introduced to the United States. Extensive worldwide clinical studies with diclofenac have demonstrated its efficacy in the treatment of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. Its overall safety and eff …
Diclofenac is the newest NSAID to be introduced to the United States. Extensive worldwide clinical studies with diclofenac hav …
Safety and Efficacy of the FLECTOR (Diclofenac Epolamine) Topical System in Children with Minor Soft Tissue Injuries: A Phase IV Non-randomized Clinical Trial.
Jones CA, Hoehler FK, Frangione V, Ledesma G, Wisman PP Jr, Jones C. Jones CA, et al. Clin Drug Investig. 2022 Jan;42(1):43-51. doi: 10.1007/s40261-021-01101-x. Epub 2021 Nov 26. Clin Drug Investig. 2022. PMID: 34826122 Free PMC article. Clinical Trial.
BACKGROUND AND OBJECTIVE: A topical formulation of diclofenac (FLECTOR diclofenac epolamine topical system (FDETS)) is approved in adults for the treatment of acute pain due to minor strains, sprains, and contusions; however, its safety and efficacy have not been in …
BACKGROUND AND OBJECTIVE: A topical formulation of diclofenac (FLECTOR diclofenac epolamine topical system (FDETS)) is approve …
Comparative clinical trial of castor oil and diclofenac sodium in patients with osteoarthritis.
Medhi B, Kishore K, Singh U, Seth SD. Medhi B, et al. Phytother Res. 2009 Oct;23(10):1469-73. doi: 10.1002/ptr.2804. Phytother Res. 2009. PMID: 19288533 Clinical Trial.
A randomized, double-blind, comparative clinical study was conducted to compare the safety and efficacy of castor oil with diclofenac sodium in patients with knee osteoarthritis. Subjects with symptoms of knee osteoarthritis were given a castor oil capsule 0.9 mL (n = 50) …
A randomized, double-blind, comparative clinical study was conducted to compare the safety and efficacy of castor oil with diclofenac …
Randomized, controlled clinical trial of safety and plasma concentrations of diclofenac in healthy neonatal foals after repeated topical application of 1% diclofenac sodium cream.
Barnett SE, Sellon DC, Hines MT, Seino KK, Knych HK. Barnett SE, et al. Am J Vet Res. 2017 Apr;78(4):405-411. doi: 10.2460/ajvr.78.4.405. Am J Vet Res. 2017. PMID: 28346003 Free article. Clinical Trial.
Venous blood samples were collected at predefined intervals following application of the diclofenac cream, and plasma diclofenac concentrations were determined by liquid chromatography-mass spectrometry. ...Plasma diclofenac concentrations peaked rapidly foll …
Venous blood samples were collected at predefined intervals following application of the diclofenac cream, and plasma diclofenac …
Penetration of topical diclofenac sodium 4 % spray gel into the synovial tissue and synovial fluid of the knee: a randomised clinical trial.
Efe T, Sagnak E, Roessler PP, Getgood A, Patzer T, Fuchs-Winkelmann S, Peterlein CD, Schofer MD. Efe T, et al. Knee Surg Sports Traumatol Arthrosc. 2014 Feb;22(2):345-50. doi: 10.1007/s00167-013-2408-0. Epub 2013 Jan 22. Knee Surg Sports Traumatol Arthrosc. 2014. PMID: 23338668 Clinical Trial.
METHODS: A total of 39 patients were randomised to two- or three-times daily application of diclofenac sodium 4 % spray gel to knees requiring surgery over a treatment period of 3 days. Within 8 h after the last application, TKA was conducted, and the diclofenac con …
METHODS: A total of 39 patients were randomised to two- or three-times daily application of diclofenac sodium 4 % spray gel to knees …
Formulation and evaluation of diclofenac potassium fast-disintegrating tablets and their clinical application in migraine patients.
Comoglu T, Dogan A, Comoglu S, Basci N. Comoglu T, et al. Drug Dev Ind Pharm. 2011 Mar;37(3):260-7. doi: 10.3109/03639045.2010.505929. Epub 2010 Aug 12. Drug Dev Ind Pharm. 2011. PMID: 20704458 Clinical Trial.
The aim of this study was to prepare fast-disintegrating tablets (FDTs) of diclofenac potassium with sufficient integrity as well as a pleasant taste, using two different fillers and binders: Tablettose 70() and Di-Pac(). ...Tablet properties such as porosity, hardness, an …
The aim of this study was to prepare fast-disintegrating tablets (FDTs) of diclofenac potassium with sufficient integrity as well as …
Diclofenac sodium. A reappraisal of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy.
Todd PA, Sorkin EM. Todd PA, et al. Drugs. 1988 Mar;35(3):244-85. doi: 10.2165/00003495-198835030-00004. Drugs. 1988. PMID: 3286213 Review.
Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) advocated for use in painful and inflammatory rheumatic and certain non-rheumatic conditions. ...In numerous clinical trials the efficacy of diclofenac is equivalent to that of the many newer and establish …
Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) advocated for use in painful and inflammatory rheumatic and certain non- …
Topical diclofenac vs placebo for the treatment of chronic Achilles tendinopathy: A randomized controlled clinical trial.
Bussin E, Cairns B, Gerschman T, Fredericson M, Bovard J, Scott A. Bussin E, et al. PLoS One. 2021 Mar 4;16(3):e0247663. doi: 10.1371/journal.pone.0247663. eCollection 2021. PLoS One. 2021. PMID: 33661967 Free PMC article. Clinical Trial.
INTRODUCTION: The application of topical diclofenac has been suggested as a possible treatment for Achilles tendinopathy. Our aim was to answer the question, is topical diclofenac more effective than placebo for the treatment of Achilles tendinopathy?. ...RESULTS: T …
INTRODUCTION: The application of topical diclofenac has been suggested as a possible treatment for Achilles tendinopathy. Our aim was …
Efficacy of systemic diclofenac sodium on intravitreal concentration.
Panahi Y, Naderi M, Jadidi K, Hoseini H, Abrishami M. Panahi Y, et al. Int Ophthalmol. 2018 Feb;38(1):99-104. doi: 10.1007/s10792-016-0428-8. Epub 2017 Jan 10. Int Ophthalmol. 2018. PMID: 28074420 Clinical Trial.
After 6 h, diclofenac concentration was statistically different, although it reduced below 1 mug/ml. CONCLUSION: Diclofenac is delivered to the inflamed eye more than healthy eye. It seems that by oral diclofenac consumption, it is possible to make a signific …
After 6 h, diclofenac concentration was statistically different, although it reduced below 1 mug/ml. CONCLUSION: Diclofenac is …
2,295 results